Disease relevance of Gynecology

• Mature results of a randomized trial of two doses of cisplatin for the treatment of ovarian cancer. Scottish Gynecology Cancer Trials Group [1].
• METHODS AND MATERIALS: Cancer specimens from 75 patients with International Federation of Gynecology and Obstetrics Stage IIB squamous cell carcinoma of the uterine cervix who had undergone radiotherapy and concurrent chemotherapy were immunohistochemically stained with COX-2 and TP antibodies and scored [2].
• STUDY DESIGN: In a private practice setting at the Infertility, Gynecology, and Obstetrics Medical Group in San Diego, 79 treatment programs included intrauterine insemination during natural cycles, 195 included clomiphene stimulation, and 53 had human menopausal gonadotropin stimulation [3].
• METHODS: Twenty-four patients with the diagnosis of primary tubal adenocarcinoma treated between 1993 and 1998 were identified through the gynecology service database and the Memorial Sloan-Kettering Cancer Center tumor registry [4].
• PATIENTS: A total of 65 patients were recruited from the Fertility and Endocrine Unit and the Gynecology Service of Brigham and Women's Hospital. MAIN OUTCOME MEASURE: Serum CA-125 levels were measured by an immunoradiometric assay and were stratified by menstrual cycle phase, diagnosis, and stage of endometriosis [5].

High impact information on Gynecology

• SETTING--Departments of Family Medicine and Obstetrics and Gynecology, Mayo Clinic, Rochester, Minn. PATIENTS--Pregnant women (1047) from the local community were screened for AUTI on initial and follow-up visits [6].
• PATIENTS AND METHODS: Bone marrow aspirates from 108 patients newly diagnosed with International Federation of Gynecology and Obstetrics stage I to III ovarian cancer were prospectively analyzed with the novel anti-cytokeratin (CK) antibody A45-B/B3 [7].
• The emergence of molecular gynecology: homeobox and Wnt genes in the female reproductive tract [8].
• Age, International Federation of Gynecology and Obstetrics (FIGO) stage, histologic type, histologic grade, MVD, as well as Ki-67, p53, and p21 protein expression, all significantly influenced survival in univariate analyses (P < or = .05) [9].
• PURPOSE: A prospective, nonrandomized, multicenter, open feasibility study of cisplatin and docetaxel as first-line chemotherapy in International Federation of Gynecology and Obstetrics (FIGO) stage IC-IV epithelial ovarian cancer was conducted [10].

Chemical compound and disease context of Gynecology

• DATA SOURCES: We reviewed four major journals in obstetrics and gynecology (American Journal of Obstetrics and Gynecology, Fertility and Sterility, Journal of Reproductive Medicine, and Obstetrics & Gynecology) [11].
• Patients with serious soft-tissue infections in obstetrics and gynecology are frequently treated with parenteral antibiotics until afebrile and clinically well for 48-72 hours, and then discharged on a broad-spectrum oral antibiotic [12].
• Obstetrics and gynecology: Supravaginal hysterectomy without ligature of the cervix, in operation for uterine fibroids: a new method. by Benjamin Franklin Baer. American Journal of Obstetrics and Diseases of Women, vol. 26, 1892 [13].
• Classic pages in obstetrics and gynecology. Operation in cases of complete prolapse. Archibald Donald. Journal of Obstetrics and Gynaecology of the British Empire, vol. 13, pp. 195-196, 1908 [14].
• DESIGN: Prospective study on women with a history of at least three consecutive miscarriages in Department I and II of Obstetrics and Gynecology, University Central Hospital of Helsinki, Finland. RESULTS: The recurrent miscarriage group as a whole exhibited gonadotrophin and androgen levels comparable to those seen in the controls [15].

Biological context of Gynecology

• Gonadotropin-releasing hormone (GnRH) agonists show promise as new therapeutic agents with considerable potential for clinical applications in endocrinology, gynecology, pediatrics, and oncology [16].
• Setting: University Departments of Obstetrics and Gynecology and Surgery. PATIENT(S): Twenty-seven women with PCOS and 20 women with normal menstrual cycles [17].
• METHODS: The University of California, San Francisco obstetrics and gynecology residency program includes a 6-week PGY-3 family planning rotation at an in-hospital clinic where abortions are provided up to 23 weeks of gestation [18].
• Classic pages in obstetrics and gynecology. Structure of the porcine LH-and FSH-releasing hormone. I. The proposed amino acid sequence. Biochemical and Biophysical Research Communications, vol. 43, pp. 1334-1339, 1971 [19].
• The subjects were 415 women, mean age 51+/-8 years (43-62 years) in peri- and postmenopause, recruited at the Menopause Center of Obstetrics and Gynecology Department of Siena University and divided in five groups [20].

Anatomical context of Gynecology

• A total of 129 patients who had undergone a radical hysterectomy for SCC of the uterine cervix at the Department of Gynecology of the Martin-Luther University, Halle-Wittenberg in 1991-2000 were included [21].
• Classic pages in obstetrics and gynecology. Notes on anhaemia, principally in its connections with the puerperal state, and with functional disease of the uterus; with cases: Walter Channing. The New England Quarterly Journal of Medicine and Surgery, vol. 1, pp. 157-188, 1842-1843 [22].
• SETTING: Second Department of Obstetrics and Gynecology of the University of Athens; Euromedica IVF Unit; and Hellenic Pasteur Institute. PATIENTS: Thirty-three patients undergoing IVF-ET divided in three groups: 8 with conception, 18 with fertilized oocytes but no conception, and 7 without fertilized oocytes [23].
• Classic pages in obstetrics and gynecology. A radiographic demonstration of the circulation through the heart in the adult and in the foetus, and the identification of the ductus arteriosus. Alfred Ernest Barclay, Sir Joseph Barcroft, Donald Henry Barron, and Kenneth James Franklin. The British Journal of Radiology, vol. 12, pp. 505-518, 1939 [24].
• To evaluate the usefulness of autoantibody detection as a nonoperative method of diagnosing endometriosis, we tested 221 sera from 215 patients from the infertility, gynecology, and gynecologic oncology services by an indirect immunofluorescence assay using monolayer cultures of an endometrial carcinoma cell line [25].

Associations of Gynecology with chemical compounds

• PURPOSE: A phase III trial was performed between October 1981 and June 1984 to compare the efficacy of single-agent cisplatin and single-agent carboplatin in previously untreated patients with International Federation of Gynecology and Obstetrics stage III or IV carcinoma of the ovary following surgery [26].
• When white cases were compared to either gynecology or community controls, relative risks were increased for long duration estrogen use and for recent use prior to diagnosis [27].
• Neoadjuvant chemotherapy consisting of 2-3 courses of cisplatin, vincristine, and bleomycin was used in the primary treatment of 36 consecutive patients with locally advanced early-stage cervical carcinoma [International Federation of Gynecology and Obstetrics (FIGO) stages Ib or IIa; tumor size, greater than or equal to 4 cm] [28].
• The main lasers used in gynecology are CO2, neodymium-yttrium aluminum garnet (Nd:YAG), and potassium tatanyl-phosphate-doubled Nd:YAG [29].
• Increased gentamicin dosage requirements: rapid elimination in 249 gynecology patients [30].

Gene context of Gynecology

• PTEN-staining status was not associated with patient age, International Federation of Gynecology and Obstetrics (FIGO) stage, myometrial invasion or histologic grade [31].
• Univariate analysis showed that expression of p53, Bax, bulk residual disease and International Federation of Gynecology and Obstetricians (FIGO) stage were all strongly correlated with response to chemotherapy (P < 0.01) [32].
• RESULTS: Compared with cystoadenomas and borderline tumors, the tessutal VEGF immunostaining was significantly higher in cystoadenocarcinomas, with the highest values detected in architectural International Federation of Gynecology and Obstetrics Grade 3 neoplasms (P2 < 0.001) [33].
• GSTT1 and/or GSTM1 null genotypes were not significantly associated with the histologic type and grade or FIGO (International Federation of Gynecology and Obstetrics) stages of the ovarian carcinomas [34].
• No association was detected between International Federation of Gynecology and Obstetrics stage and receptor status, but there was a somewhat lower frequency of ER positivity in poorly differentiated tumors (P = 0.07) [35].

Analytical, diagnostic and therapeutic context of Gynecology

• METHODS: Between November 2000 and November 2001, mothers were recruited after delivery of their offspring at the Department of Gynecology and Obstetrics at the University of Ulm, Ulm, Germany. The H. pylori infection status of the women was determined by 13C urea breath test [36].
• Surgeons engaged in the practice of obstetrics and gynecology should have a clear understanding of the hepatitis B antigen (Australia antigen) serologic test [37].
• METHODS: We measured vascular endothelial growth factor in pretreatment serum samples of 60 women with International Federation of Gynecology and Obstetrics stages I to IV epithelial ovarian cancer, using an enzyme-linked immunosorbent assay [38].
• Applications of laser surgery in gynecology. Hype or high tech [39]?
• OBJECTIVE: To evaluate the safety and effectiveness of transvaginal ultrasound guided injection of hot saline into the ovarian stroma in polycystic ovary syndrome (PCOS) cases in an office based gynecology practice under local anesthesia [40].

References