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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Laparoscopic sacral colpopexy versus total vaginal mesh for vaginal vault prolapse: a randomized trial.

OBJECTIVE: To compare the laparoscopic sacral colpopexy and total vaginal mesh for vaginal vault prolapse. STUDY DESIGN: Women with symptomatic stage ≥2 vault prolapse were randomly allocated the laparoscopic sacral colpopexy (53) or total vaginal mesh (55). Primary outcome measures were objective success rates at pelvic organ prolapse quantification sites individually and collectively. Secondary outcome measures included perioperative outcomes, patient satisfaction, quality of life outcomes, complications, and reoperations. RESULTS: The laparoscopic sacral colpopexy group had a longer operating time, reduced inpatient days, and quicker return to activities of daily living as compared with the total vaginal mesh group. At the 2-year review, the total objective success rate at all vaginal sites was 41 of 53 (77%) for laparoscopic sacral colpopexy as compared with 23 of 55 (43%) in total vaginal mesh (P < .001). Reoperation rate was significantly higher after the vaginal mesh surgery 12 of 55 (22%) as compared with laparoscopic sacral colpopexy 3 of 53 (5%) (P = .006). CONCLUSION: At 2 years, the laparoscopic sacral colpopexy had a higher satisfaction rate and objective success rate than the total vaginal mesh with lower perioperative morbidity and reoperation rate.[1]


  1. Laparoscopic sacral colpopexy versus total vaginal mesh for vaginal vault prolapse: a randomized trial. Maher, C.F., Feiner, B., DeCuyper, E.M., Nichlos, C.J., Hickey, K.V., O'Rourke, P. Am. J. Obstet. Gynecol. (2011) [Pubmed]
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