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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Cloning, localization, and permanent expression of a Drosophila octopamine receptor.

A cDNA for a member of the G protein- coupled receptor family was isolated from Drosophila using a probe derived from a human beta 2-adrenergic receptor cDNA. This Drosophila receptor gene is localized at 99A10-B1 on the right arm of chromosome 3 and is preferentially expressed in Drosophila heads. The insect octopamine receptor has been permanently expressed in mammalian cells, where it mediates the attenuation of adenylate cyclase activity and exhibits a pharmacological profile consistent with an octopamine type 1 receptor. Sequence and pharmacological comparisons indicate that the octopamine receptor is unique but closely related to mammalian adrenergic receptors, perhaps as an evolutionary precursor.[1]

References

  1. Cloning, localization, and permanent expression of a Drosophila octopamine receptor. Arakawa, S., Gocayne, J.D., McCombie, W.R., Urquhart, D.A., Hall, L.M., Fraser, C.M., Venter, J.C. Neuron (1990) [Pubmed]
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