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Gene Review

Oct-TyrR  -  Octopamine-Tyramine receptor

Drosophila melanogaster

Synonyms: CG7485, DmTyrR, Dmel\CG7485, Dmoct/tyr, DrmOTR, ...
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Disease relevance of TyrR


High impact information on TyrR


Biological context of TyrR


Anatomical context of TyrR

  • The increase in intracellular calcium levels induced by activation of the OctyR99AB receptor can potentiate the ability of activation of a co-expressed beta2-adrenergic receptor to increase oocyte cyclic AMP levels [10].
  • Crickets injected with epinastine or mianserin, OA receptor antagonists, into the hemolymph exhibited a complete impairment of appetitive learning to associate a visual pattern with water reward, but aversive learning with saline punishment was unaffected [11].

Associations of TyrR with chemical compounds


Other interactions of TyrR


Analytical, diagnostic and therapeutic context of TyrR


  1. Amtyr1: characterization of a gene from honeybee (Apis mellifera) brain encoding a functional tyramine receptor. Blenau, W., Balfanz, S., Baumann, A. J. Neurochem. (2000) [Pubmed]
  2. Molecular and pharmacological analysis of an octopamine receptor from American cockroach and fruit fly in response to plant essential oils. Enan, E.E. Arch. Insect Biochem. Physiol. (2005) [Pubmed]
  3. Cloning, localization, and permanent expression of a Drosophila octopamine receptor. Arakawa, S., Gocayne, J.D., McCombie, W.R., Urquhart, D.A., Hall, L.M., Fraser, C.M., Venter, J.C. Neuron (1990) [Pubmed]
  4. Agonist-specific coupling of a cloned Drosophila octopamine/tyramine receptor to multiple second messenger systems. Robb, S., Cheek, T.R., Hannan, F.L., Hall, L.M., Midgley, J.M., Evans, P.D. EMBO J. (1994) [Pubmed]
  5. Cloning and characterization of a Drosophila tyramine receptor. Saudou, F., Amlaiky, N., Plassat, J.L., Borrelli, E., Hen, R. EMBO J. (1990) [Pubmed]
  6. A novel octopamine receptor with preferential expression in Drosophila mushroom bodies. Han, K.A., Millar, N.S., Davis, R.L. J. Neurosci. (1998) [Pubmed]
  7. A trace amine, tyramine, functions as a neuromodulator in Drosophila melanogaster. Nagaya, Y., Kutsukake, M., Chigusa, S.I., Komatsu, A. Neurosci. Lett. (2002) [Pubmed]
  8. Cloning and functional characterization of a novel dopamine receptor from Drosophila melanogaster. Feng, G., Hannan, F., Reale, V., Hon, Y.Y., Kousky, C.T., Evans, P.D., Hall, L.M. J. Neurosci. (1996) [Pubmed]
  9. Molecular cloning and heterologous expression of an alpha-adrenergic-like octopamine receptor from the silkworm Bombyx mori. Ohtani, A., Arai, Y., Ozoe, F., Ohta, H., Narusuye, K., Huang, J., Enomoto, K., Kataoka, H., Hirota, A., Ozoe, Y. Insect Mol. Biol. (2006) [Pubmed]
  10. The expression of a cloned Drosophila octopamine/tyramine receptor in Xenopus oocytes. Reale, V., Hannan, F., Midgley, J.M., Evans, P.D. Brain Res. (1997) [Pubmed]
  11. Roles of octopaminergic and dopaminergic neurons in mediating reward and punishment signals in insect visual learning. Unoki, S., Matsumoto, Y., Mizunami, M. Eur. J. Neurosci. (2006) [Pubmed]
  12. Aminergic receptors in Drosophila melanogaster: responsiveness of adenylate cyclase to putative neurotransmitters. Uzzan, A., Dudai, Y. J. Neurochem. (1982) [Pubmed]
  13. Cloning and expression of a complementary DNA encoding a molluscan octopamine receptor that couples to chloride channels in HEK293 cells. Gerhardt, C.C., Lodder, H.C., Vincent, M., Bakker, R.A., Planta, R.J., Vreugdenhil, E., Kits, K.S., van Heerikhuizen, H. J. Biol. Chem. (1997) [Pubmed]
  14. Modulation of tyramine signaling by osmolality in an insect secretory epithelium. Blumenthal, E.M. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  15. A new family of insect tyramine receptors. Cazzamali, G., Klaerke, D.A., Grimmelikhuijzen, C.J. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  16. Temporal and spatial expression patterns of two G-protein coupled receptors in Drosophila melanogaster. Hannan, F., Hall, L.M. Invert. Neurosci. (1996) [Pubmed]
  17. Site-directed mutagenesis studies on the Drosophila octopamine/tyramine receptor. Chatwin, H.M., Rudling, J.E., Patel, D., Reale, V., Evans, P.D. Insect Biochem. Mol. Biol. (2003) [Pubmed]
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