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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Influence of hypoxia on 5-lipoxygenase pathway in rat alveolar macrophages.

The effect of hypoxia was studied on the ionophore A23187-induced leukotriene production by rat alveolar macrophages. The production of LTB4 and LTC4 decreased with reducing oxygenation without change of cell viability. The synthesis of 5-HETE increased during hypoxia and the total production of LTB4, LTC4 and 5-HETE, the major metabolites of the 5-lipoxygenase pathway in rat alveolar macrophages, was equal during normoxia and hypoxia. Arachidonate release and LTA4-converting into LTB4 and LTC4 was unaffected by hypoxia. LTB4- and LTC4-degradating activities were not affected by hypoxia. These results suggest that LTA4 synthase reaction of leukotrienes biosynthesis might be suppressed by hypoxia.[1]


  1. Influence of hypoxia on 5-lipoxygenase pathway in rat alveolar macrophages. Ohwada, A., Kira, S., Yamashita, T. Prostaglandins Leukot. Essent. Fatty Acids (1990) [Pubmed]
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