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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Aquaporin-4-dependent edema clearance following status epilepticus.

We investigated the role of aquaporin-4 in the development of cerebral edema following kainic acid-induced status epilepticus (SE) using specific gravimetry and T2 MRI techniques at 6h, 1 day, 4 days and 7 days after SE. Our results indicate significantly greater tissue edema and T2 MRI changes in AQP4(-/-) compared to AQP4(+/+) mice that peaks at about 1 day after SE (greater in hippocampus relative to cortex). These results have implications for the mechanisms of edema formation and clearance following intense seizure activity.[1]

References

  1. Aquaporin-4-dependent edema clearance following status epilepticus. Lee, D.J., Amini, M., Hamamura, M.J., Hsu, M.S., Seldin, M.M., Nalcioglu, O., Binder, D.K. Epilepsy Res. (2012) [Pubmed]
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