MLL Duplication in a Pediatric Patient With B-Cell Lymphoblastic Lymphoma.
Lymphoblastic lymphoma is the second most common type of non-Hodgkin lymphoma seen in children. Approximately, 90% of lymphoblastic lymphomas arise from T cells, with the remaining 10% being B-cell-lineage derived. Although T-cell lymphoblastic lymphoma most frequently occurs in the anterior mediastinum (thymus), B-cell lymphoblastic lymphoma (B-LBL) predominates in extranodal sites such as skin and bone. Here, we describe a pediatric B-LBL patient who presented with extensive abdominal involvement and whose lymphoma cells displayed segmental duplication of the mixed lineage leukemia (MLL) gene. MLL duplication/amplification has been described primarily in acute myeloid leukemia and myelodysplastic syndrome with no published reports of discrete MLL duplication/amplification events in B-LBL. The MLL gene duplication noted in this case may represent a novel mechanism for tumorigenesis in B-LBL.[1]References
- MLL Duplication in a Pediatric Patient With B-Cell Lymphoblastic Lymphoma. Mater, D.V., Goodman, B.K., Wang, E., Gaca, A.M., Wechsler, D.S. J. Pediatr. Hematol. Oncol. (2011) [Pubmed]
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