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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Proline-specific proteases in cultivated neuronal and glial cells.

The activities of several proline-specific endo- and exopeptidases were determined in homogenates of immunocytochemically defined cultures of astrocytes, oligodendrocytes and neurones obtained from rat cerebral cortex. Astrocytes are significantly enriched in post-proline cleaving dipeptidyl peptidase II, prolidase and aminopeptidase P activities; neurones and astrocytes contain prolyl endopeptidase. Dipeptidyl peptidase IV and prolyl carboxypeptidase activities are low or absent in the cultures. The physiological significance of these findings is discussed.[1]


  1. Proline-specific proteases in cultivated neuronal and glial cells. Mentlein, R., von Kolszynski, M., Sprang, R., Lucius, R. Brain Res. (1990) [Pubmed]
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