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Gene Review

Dpp4  -  dipeptidylpeptidase 4

Rattus norvegicus

Synonyms: Bile canaliculus domain-specific membrane glycoprotein, CD26, Cd26, DPP IV, DPPIV, ...
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Disease relevance of Dpp4


High impact information on Dpp4


Chemical compound and disease context of Dpp4


Biological context of Dpp4


Anatomical context of Dpp4

  • Following injection of the protein-tyrosine phosphatase inhibitor bpV(phen), DPP IV levels markedly decreased by 40% both in plasma membrane and G/E fractions [16].
  • DPP IV was found phosphorylated after incubation of nonsolubilized G/E membranes with [gamma-32P]ATP [16].
  • We identify here, by MS, several tyrosine-phosphorylated proteins in a rat liver Golgi/endosome (G/E) fraction including DPP IV [16].
  • As shown in a cell-free translation system, the amino-terminal 34 amino acids of rat DPPIV are involved in translocating nascent polypeptide across the membrane of microsomes and in anchoring the translocated polypeptide in the microsomal membrane [9].
  • cDNA cloning for a bile canaliculus domain-specific membrane glycoprotein of rat hepatocytes [18].

Associations of Dpp4 with chemical compounds


Physical interactions of Dpp4

  • Fibronectin appeared to bind DPP IV at a site distinct from its exopeptidase substrate recognition site since protease inhibitors such as competitive peptide substrates and phenylmethanesulphonyl fluoride enhanced binding, possibly as a result of an altered conformation of DPP IV [21].
  • Approximately 60% of the dipeptidyl peptidase IV interacted with either one or both of the lectins while only 30% of the aminopeptidase N did so [22].
  • Treatment of both enzymes with neuraminidase enhanced the binding of aminopeptidase to RCAI-Sepharose by 4-fold but did not alter the binding patterns of dipeptidyl peptidase IV [22].

Regulatory relationships of Dpp4


Other interactions of Dpp4


Analytical, diagnostic and therapeutic context of Dpp4


  1. A novel consensus motif in fibronectin mediates dipeptidyl peptidase IV adhesion and metastasis. Cheng, H.C., Abdel-Ghany, M., Pauli, B.U. J. Biol. Chem. (2003) [Pubmed]
  2. Efficacy and safety of repeated hepatocyte transplantation for significant liver repopulation in rodents. Rajvanshi, P., Kerr, A., Bhargava, K.K., Burk, R.D., Gupta, S. Gastroenterology (1996) [Pubmed]
  3. Role of dipeptidyl peptidase IV (gp 108) in passive Heymann nephritis. Use of dipeptidyl peptidase IV-deficient rats. Natorio, Y., Hayakawa, I., Shibata, S. Am. J. Pathol. (1989) [Pubmed]
  4. Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: a euglycemic-hyperinsulinemic clamp study. Pospisilik, J.A., Stafford, S.G., Demuth, H.U., McIntosh, C.H., Pederson, R.A. Diabetes (2002) [Pubmed]
  5. Bone marrow as a potential source of hepatic oval cells. Petersen, B.E., Bowen, W.C., Patrene, K.D., Mars, W.M., Sullivan, A.K., Murase, N., Boggs, S.S., Greenberger, J.S., Goff, J.P. Science (1999) [Pubmed]
  6. Newly synthesized hepatocyte plasma membrane proteins are transported in transcytotic vesicles in the bile duct-ligated rat. Barr, V.A., Hubbard, A.L. Gastroenterology (1993) [Pubmed]
  7. Lung endothelial dipeptidyl peptidase IV is an adhesion molecule for lung-metastatic rat breast and prostate carcinoma cells. Johnson, R.C., Zhu, D., Augustin-Voss, H.G., Pauli, B.U. J. Cell Biol. (1993) [Pubmed]
  8. Modulation of transcytotic and direct targeting pathways in a polarized thyroid cell line. Zurzolo, C., Le Bivic, A., Quaroni, A., Nitsch, L., Rodriguez-Boulan, E. EMBO J. (1992) [Pubmed]
  9. Molecular dissection of the NH2-terminal signal/anchor sequence of rat dipeptidyl peptidase IV. Hong, W.J., Doyle, D. J. Cell Biol. (1990) [Pubmed]
  10. Metformin causes reduction of food intake and body weight gain and improvement of glucose intolerance in combination with dipeptidyl peptidase IV inhibitor in Zucker fa/fa rats. Yasuda, N., Inoue, T., Nagakura, T., Yamazaki, K., Kira, K., Saeki, T., Tanaka, I. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  11. Effects of the Combination of a Dipeptidyl Peptidase IV Inhibitor and an Insulin Secretagogue on Glucose and Insulin Levels in Mice and Rats. Yamazaki, K., Yasuda, N., Inoue, T., Yamamoto, E., Sugaya, Y., Nagakura, T., Shinoda, M., Clark, R., Saeki, T., Tanaka, I. J. Pharmacol. Exp. Ther. (2007) [Pubmed]
  12. Proteinuria induced by anti-dipeptidyl peptidase IV (gp108); role of circulating and glomerular antigen. Natori, Y., Shindo, N., Natori, Y. Clin. Exp. Immunol. (1994) [Pubmed]
  13. Dipeptidyl peptidase IV in C6 rat glioma cell line differentiation. Sedo, A., Malík, R., Krepela, E. Biol. Chem. (1998) [Pubmed]
  14. Retrieval of the mrp2 gene encoded conjugate export pump from the canalicular membrane contributes to cholestasis induced by tert-butyl hydroperoxide and chloro-dinitrobenzene. Schmitt, M., Kubitz, R., Wettstein, M., vom Dahl, S., Häussinger, D. Biol. Chem. (2000) [Pubmed]
  15. Liraglutide, a Long-Acting Glucagon-Like Peptide-1 Analog, Reduces Body Weight and Food Intake in Obese Candy-Fed Rats, Whereas a Dipeptidyl Peptidase-IV Inhibitor, Vildagliptin, Does Not. Raun, K., von Voss, P., Gotfredsen, C.F., Golozoubova, V., Rolin, B., Knudsen, L.B. Diabetes (2007) [Pubmed]
  16. Insulin-dependent phosphorylation of DPP IV in liver. Evidence for a role of compartmentalized c-Src. Bilodeau, N., Fiset, A., Poirier, G.G., Fortier, S., Gingras, M.C., Lavoie, J.N., Faure, R.L. FEBS J. (2006) [Pubmed]
  17. Identification of the bile canalicular cell surface molecule GP110 as the ectopeptidase dipeptidyl peptidase IV: an analysis by tissue distribution, purification and N-terminal amino acid sequence. McCaughan, G.W., Wickson, J.E., Creswick, P.F., Gorrell, M.D. Hepatology (1990) [Pubmed]
  18. cDNA cloning for a bile canaliculus domain-specific membrane glycoprotein of rat hepatocytes. Hong, W., Doyle, D. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  19. Primary structure of rat liver dipeptidyl peptidase IV deduced from its cDNA and identification of the NH2-terminal signal sequence as the membrane-anchoring domain. Ogata, S., Misumi, Y., Ikehara, Y. J. Biol. Chem. (1989) [Pubmed]
  20. Improvement of high fat-diet-induced insulin resistance in dipeptidyl peptidase IV-deficient Fischer rats. Yasuda, N., Nagakura, T., Yamazaki, K., Inoue, T., Tanaka, I. Life Sci. (2002) [Pubmed]
  21. Evidence for a role of dipeptidyl peptidase IV in fibronectin-mediated interactions of hepatocytes with extracellular matrix. Piazza, G.A., Callanan, H.M., Mowery, J., Hixson, D.C. Biochem. J. (1989) [Pubmed]
  22. Interaction of purified brush-border membrane aminopeptidase N and dipeptidyl peptidase IV with lectin-sepharose derivatives. Erickson, R.H., Kim, Y.S. Biochim. Biophys. Acta (1983) [Pubmed]
  23. Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Kieffer, T.J., McIntosh, C.H., Pederson, R.A. Endocrinology (1995) [Pubmed]
  24. Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPY Y1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26). Dimitrijević, M., Stanojević, S., Vujić, V., Kovacević-Jovanović, V., Beck-Sickinger, A., Demuth, H., von Hörsten, S. J. Neuroimmunol. (2002) [Pubmed]
  25. CD26/DPP IV in experimental and clinical organ transplantation. Korom, S., de Meester, I., Belyaev, A., Schmidbauer, G., Schwemmle, K. Adv. Exp. Med. Biol. (2003) [Pubmed]
  26. Cell competition leads to a high level of normal liver reconstitution by transplanted fetal liver stem/progenitor cells. Oertel, M., Menthena, A., Dabeva, M.D., Shafritz, D.A. Gastroenterology (2006) [Pubmed]
  27. Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury. Michalopoulos, G.K., Barua, L., Bowen, W.C. Hepatology (2005) [Pubmed]
  28. Immunosuppression using the mTOR inhibition mechanism affects replacement of rat liver with transplanted cells. Wu, Y.M., Joseph, B., Gupta, S. Hepatology (2006) [Pubmed]
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