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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Redesign of the coenzyme specificity of a dehydrogenase by protein engineering.

Directed mutagenesis and molecular modelling have been used to identify a set of amino-acid side chains in glutathione reductase that confer specificity for the coenzyme NADP+. Systematic replacement of these amino acids, all of which occur in a 'fingerprint' structural motif in the NADP+-binding domain, leaves the substrate specificity unchanged but converts the enzyme into one displaying a marked preference for the coenzyme NAD+.[1]

References

  1. Redesign of the coenzyme specificity of a dehydrogenase by protein engineering. Scrutton, N.S., Berry, A., Perham, R.N. Nature (1990) [Pubmed]
 
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