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MeSH Review

Protein Engineering

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Analytical, diagnostic and therapeutic context of Protein Engineering


  1. Kallistatin: a novel human serine proteinase inhibitor. Molecular cloning, tissue distribution, and expression in Escherichia coli. Chai, K.X., Chen, L.M., Chao, J., Chao, L. J. Biol. Chem. (1993) [Pubmed]
  2. Structure-based combinatorial protein engineering (SCOPE). O'Maille, P.E., Bakhtina, M., Tsai, M.D. J. Mol. Biol. (2002) [Pubmed]
  3. Protein engineering of toluene-o-xylene monooxygenase from Pseudomonas stutzeri OX1 for synthesizing 4-methylresorcinol, methylhydroquinone, and pyrogallol. Vardar, G., Wood, T.K. Appl. Environ. Microbiol. (2004) [Pubmed]
  4. Fimbriae of Bacteroides nodosus: protein engineering of the structural subunit for the production of an exogenous peptide. Jennings, P.A., Bills, M.M., Irving, D.O., Mattick, J.S. Protein Eng. (1989) [Pubmed]
  5. Engineering dihydropteroate synthase (DHPS) for efficient expression on M13 phage. Brockmann, E.C., Lamminmäki, U., Saviranta, P. Biochim. Biophys. Acta (2005) [Pubmed]
  6. Conversion of allosteric inhibition to activation in phosphofructokinase by protein engineering. Lau, F.T., Fersht, A.R. Nature (1987) [Pubmed]
  7. Site-directed mutagenesis reveals role of mobile arginine residue in lactate dehydrogenase catalysis. Clarke, A.R., Wigley, D.B., Chia, W.N., Barstow, D., Atkinson, T., Holbrook, J.J. Nature (1986) [Pubmed]
  8. Lung surfactant proteins involved in innate immunity. Eggleton, P., Reid, K.B. Curr. Opin. Immunol. (1999) [Pubmed]
  9. A continent of plant defense peptide diversity: cyclotides in Australian Hybanthus (Violaceae). Simonsen, S.M., Sando, L., Ireland, D.C., Colgrave, M.L., Bharathi, R., Göransson, U., Craik, D.J. Plant Cell (2005) [Pubmed]
  10. Folding of human superoxide dismutase: disulfide reduction prevents dimerization and produces marginally stable monomers. Lindberg, M.J., Normark, J., Holmgren, A., Oliveberg, M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  11. tRNA(2Gln) mutants that translate the CGA arginine codon as glutamine in Escherichia coli. Tsai, F., Curran, J.F. RNA (1998) [Pubmed]
  12. Protein engineering of toluene-o-xylene monooxygenase from Pseudomonas stutzeri OX1 for enhanced chlorinated ethene degradation and o-xylene oxidation. Vardar, G., Wood, T.K. Appl. Microbiol. Biotechnol. (2005) [Pubmed]
  13. Protein engineering of toluene-o-xylene monooxygenase from Pseudomonas stutzeri OX1 for oxidizing nitrobenzene to 3-nitrocatechol, 4-nitrocatechol, and nitrohydroquinone. Vardar, G., Ryu, K., Wood, T.K. J. Biotechnol. (2005) [Pubmed]
  14. A ligand-reversible dimerization system for controlling protein-protein interactions. Rollins, C.T., Rivera, V.M., Woolfson, D.N., Keenan, T., Hatada, M., Adams, S.E., Andrade, L.J., Yaeger, D., van Schravendijk, M.R., Holt, D.A., Gilman, M., Clackson, T. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  15. Mechanisms of drug/H+ antiport: complete cysteine-scanning mutagenesis and the protein engineering approach. Tamura, N., Konishi, S., Yamaguchi, A. Current opinion in chemical biology. (2003) [Pubmed]
  16. The structure of the transition state for folding of chymotrypsin inhibitor 2 analysed by protein engineering methods: evidence for a nucleation-condensation mechanism for protein folding. Itzhaki, L.S., Otzen, D.E., Fersht, A.R. J. Mol. Biol. (1995) [Pubmed]
  17. Re-design of Saccharomyces cerevisiae flavocytochrome b2: introduction of L-mandelate dehydrogenase activity. Sinclair, R., Reid, G.A., Chapman, S.K. Biochem. J. (1998) [Pubmed]
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  20. RNase 3 (ECP) is an extraordinarily stable protein among human pancreatic-type RNases. Maeda, T., Mahara, K., Kitazoe, M., Futami, J., Takidani, A., Kosaka, M., Tada, H., Seno, M., Yamada, H. J. Biochem. (2002) [Pubmed]
  21. DX-890 (Dyax). Wark, P.A. IDrugs : the investigational drugs journal. (2002) [Pubmed]
  22. A productive NADP+ binding mode of ferredoxin-NADP + reductase revealed by protein engineering and crystallographic studies. Deng, Z., Aliverti, A., Zanetti, G., Arakaki, A.K., Ottado, J., Orellano, E.G., Calcaterra, N.B., Ceccarelli, E.A., Carrillo, N., Karplus, P.A. Nat. Struct. Biol. (1999) [Pubmed]
  23. Protein engineering of cytochrome b562 for quinone binding and light-induced electron transfer. Hay, S., Wallace, B.B., Smith, T.A., Ghiggino, K.P., Wydrzynski, T. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  24. Does trifluoroethanol affect folding pathways and can it be used as a probe of structure in transition states? Main, E.R., Jackson, S.E. Nat. Struct. Biol. (1999) [Pubmed]
  25. Engineering dehydrated amino acid residues in the antimicrobial peptide nisin. Kuipers, O.P., Rollema, H.S., Yap, W.M., Boot, H.J., Siezen, R.J., de Vos, W.M. J. Biol. Chem. (1992) [Pubmed]
  26. Photoreactive bicyclic amino acids as substrates for mutant Escherichia coli phenylalanyl-tRNA synthetases. Bentin, T., Hamzavi, R., Salomonsson, J., Roy, H., Ibba, M., Nielsen, P.E. J. Biol. Chem. (2004) [Pubmed]
  27. Protein engineering of the tissue inhibitor of metalloproteinase 1 (TIMP-1) inhibitory domain. In search of selective matrix metalloproteinase inhibitors. Wei, S., Chen, Y., Chung, L., Nagase, H., Brew, K. J. Biol. Chem. (2003) [Pubmed]
  28. Protein engineering of alcohol dehydrogenases: effects of amino acid changes at positions 93 and 48 of yeast ADH1. Creaser, E.H., Murali, C., Britt, K.A. Protein Eng. (1990) [Pubmed]
  29. Inhibition of the CD28-CD80 co-stimulation signal by a CD28-binding affibody ligand developed by combinatorial protein engineering. Sandström, K., Xu, Z., Forsberg, G., Nygren, P.A. Protein Eng. (2003) [Pubmed]
  30. Protein engineering of diphtheria-toxin-related interleukin-2 fusion toxins to increase cytotoxic potency for high-affinity IL-2-receptor-bearing target cells. Kiyokawa, T., Williams, D.P., Snider, C.E., Strom, T.B., Murphy, J.R. Protein Eng. (1991) [Pubmed]
  31. Human alpha-subunit analogs act as partial agonists to the thyroid-stimulating hormone receptor: differential effects of free and yoked subunits. Angelova, K., Fremont, V., Jain, R., Zhang, M., Puett, D., Narayan, P., Szkudlinski, M.W. Endocrine (2004) [Pubmed]
  32. Mechanical unfolding of TNfn3: the unfolding pathway of a fnIII domain probed by protein engineering, AFM and MD simulation. Ng, S.P., Rounsevell, R.W., Steward, A., Geierhaas, C.D., Williams, P.M., Paci, E., Clarke, J. J. Mol. Biol. (2005) [Pubmed]
  33. Phosphorylation of eIF4E attenuates its interaction with mRNA 5' cap analogs by electrostatic repulsion: intein-mediated protein ligation strategy to obtain phosphorylated protein. Zuberek, J., Wyslouch-Cieszynska, A., Niedzwiecka, A., Dadlez, M., Stepinski, J., Augustyniak, W., Gingras, A.C., Zhang, Z., Burley, S.K., Sonenberg, N., Stolarski, R., Darzynkiewicz, E. RNA (2003) [Pubmed]
  34. Mutational analysis of the interaction between albumin-binding domain from streptococcal protein G and human serum albumin. Linhult, M., Binz, H.K., Uhlén, M., Hober, S. Protein Sci. (2002) [Pubmed]
  35. Novel roles of kallistatin, a specific tissue kallikrein inhibitor, in vascular remodeling. Chao, J., Miao, R.Q., Chen, V., Chen, L.M., Chao, L. Biol. Chem. (2001) [Pubmed]
  36. Crystallization and chemical modification of disulfide bond of calf chymosin. Huang, K., Chen, S.Z., Yang, K.Y. Chin. J. Biotechnol. (1991) [Pubmed]
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