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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Reduction in Q wave myocardial infarctions with gemfibrozil in the Helsinki Heart Study.

The Helsinki Heart Study demonstrated a 34% (p less than 0.02) reduction in the incidence of cardiac end points (myocardial infarction and cardiac death) with the use of gemfibrozil compared with the use of a placebo in dyslipidemic middle-aged men. The major effect was confined to nonfatal myocardial infarctions. In this study we analyzed the effect of gemfibrozil therapy on the incidences of Q wave and non-Q wave infarctions, since the long-term prognoses of these two types of myocardial infarction may be different. The analyses indicated a 45% reduction (P less than 0.02, log-rank test) in the cumulative incidence of Q wave infarctions in the gemfibrozil group without a statistically significant effect on either the rate of non-Q wave infarctions or of coronary deaths. The reduction in the incidence of Q wave infarctions became evident during the second half of the 5-year study period.[1]

References

  1. Reduction in Q wave myocardial infarctions with gemfibrozil in the Helsinki Heart Study. Mänttäri, M., Romo, M., Manninen, V., Koskinen, P., Huttunen, J.K., Heinonen, O.P., Frick, M.H. Am. Heart J. (1990) [Pubmed]
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