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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Infarction


Psychiatry related information on Infarction


High impact information on Infarction

  • Patients with normal ventricles or evidence of infarction in the distant past had no detectable levels of either VEGF mRNA or HIF-1alpha mRNA [2].
  • On days 3 to 7 after infarction, 1749 patients were randomly assigned to receive oral trandolapril (876 patients) or placebo (873 patients) [10].
  • Thus, the findings in the MILIS population do not support the assertion that digoxin therapy is excessively hazardous after infarction, but the existence of an undetected harmful effect can only be excluded with a randomized study [11].
  • The relation between fibrinogen and infarction, and between fibrinogen and stroke, became weaker when blood pressure, serum cholesterol, and smoking habits were taken into account, but was still significant for stroke [12].
  • The results indicate that infusion of nitroprusside in the early phase of acute infarction limits complications, possibly by reducing infarct size [13].

Chemical compound and disease context of Infarction

  • One hundred sixty-eight patients (47 per cent), who were without major complications, elevation of total serum creatine phosphokinase, or electrocardiographic evidence of transmural infarction during the first day, could be designated "low-risk" patients [14].
  • A comparison of digoxin and dobutamine in patients with acute infarction and cardiac failure [15].
  • We conclude that diltiazem was effective in preventing early reinfarction and severe angina after non-Q-wave infarction and that it was also safe and generally well tolerated [16].
  • In six patients with infarction shortly after these studies and in two in whom the infarction developed during hemodynamic monitoring or during angiography the onset of infarction was indistinguishable from the onset of anginal attacks [17].
  • In 417 patients in whom treatment was started within four months of infarction oxprenolol increased the six-year cumulative survival rate from 77 to 95 per cent (P less than 0.001) [18].

Biological context of Infarction


Anatomical context of Infarction


Gene context of Infarction

  • Thus, our investigation revealed a previously uncharacterized role for c-kit signaling after infarction by mediating bone marrow-derived NK and angiogenic cell mobilization, which contributes to improved remodeling and cardiac function after MI [29].
  • Systemic administration of EPO (5,000 units/kg of body weight, i.p.) after middle-cerebral artery occlusion in rats dramatically reduces the volume of infarction 24 h later, in concert with an almost complete reduction in the number of terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling of neurons within the ischemic penumbra [30].
  • Preeclamptic patients with extensive placental infarction exhibited higher plasma PAI activity (24.1 U/mL v 11.6 U/mL) and PAI-1 values (305 ng/mL v 80.9 ng/mL) than preeclamptic patients without extensive placental infarction [31].
  • In contrast, PAI-2 levels were reduced in preeclamptic patients with infarction in comparison with those of patients without infarction (141 ng/mL v 212.9 ng/mL) [31].
  • Structural analysis 1, 2, and 5 weeks after infarction revealed that infarct healing was virtually abolished in Plg-/- mice, indicating that the plasminogen system is required for the repair process of the heart after infarction [32].

Analytical, diagnostic and therapeutic context of Infarction


  1. Intramuscular lidocaine for prevention of lethal arrhythmias in the prehospitalization phase of acute myocardial infarction. Koster, R.W., Dunning, A.J. N. Engl. J. Med. (1985) [Pubmed]
  2. Early expression of angiogenesis factors in acute myocardial ischemia and infarction. Lee, S.H., Wolf, P.L., Escudero, R., Deutsch, R., Jamieson, S.W., Thistlethwaite, P.A. N. Engl. J. Med. (2000) [Pubmed]
  3. Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. Yet, S.F., Perrella, M.A., Layne, M.D., Hsieh, C.M., Maemura, K., Kobzik, L., Wiesel, P., Christou, H., Kourembanas, S., Lee, M.E. J. Clin. Invest. (1999) [Pubmed]
  4. Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. Li, Q., Li, B., Wang, X., Leri, A., Jana, K.P., Liu, Y., Kajstura, J., Baserga, R., Anversa, P. J. Clin. Invest. (1997) [Pubmed]
  5. Preserved complex emotion-based learning in amnesia. Turnbull, O.H., Evans, C.E. Neuropsychologia. (2006) [Pubmed]
  6. Expression of apolipoprotein E in ballooned neurons-comparative immunohistochemical study on neurodegenerative disorders and infarction. Aoki, K., Uchihara, T., Nakamura, A., Komori, T., Arai, N., Mizutani, T. Acta Neuropathol. (2003) [Pubmed]
  7. An immunologic abnormality common to Bickerstaff's brain stem encephalitis and Fisher's syndrome. Yuki, N., Sato, S., Tsuji, S., Hozumi, I., Miyatake, T. J. Neurol. Sci. (1993) [Pubmed]
  8. Unexpected accumulation of thallium-201 in bilateral thalamic venous infarction induced by arteriovenous fistula in the posterior fossa: report of a case. Tamamoto, F., Nakanishi, A., Takanashi, T., Ishizaki, H., Nagasawa, H., Maehara, T., Ohno, S., Otsubo, Y. Annals of nuclear medicine. (2003) [Pubmed]
  9. Transient mutism after brain stem infarction (ref. Acta Neurochirurgia 1999, 141: 209-213). Erşahin, Y. Acta neurochirurgica. (1999) [Pubmed]
  10. A clinical trial of the angiotensin-converting-enzyme inhibitor trandolapril in patients with left ventricular dysfunction after myocardial infarction. Trandolapril Cardiac Evaluation (TRACE) Study Group. Køber, L., Torp-Pedersen, C., Carlsen, J.E., Bagger, H., Eliasen, P., Lyngborg, K., Videbaek, J., Cole, D.S., Auclert, L., Pauly, N.C. N. Engl. J. Med. (1995) [Pubmed]
  11. Digoxin therapy and mortality after myocardial infarction. Experience in the MILIS Study. Muller, J.E., Turi, Z.G., Stone, P.H., Rude, R.E., Raabe, D.S., Jaffe, A.S., Gold, H.K., Gustafson, N., Poole, W.K., Passamani, E. N. Engl. J. Med. (1986) [Pubmed]
  12. Fibrinogen as a risk factor for stroke and myocardial infarction. Wilhelmsen, L., Svärdsudd, K., Korsan-Bengtsen, K., Larsson, B., Welin, L., Tibblin, G. N. Engl. J. Med. (1984) [Pubmed]
  13. Effect of sodium nitroprusside on mortality in acute myocardial infarction. Durrer, J.D., Lie, K.I., van Capelle, F.J., Durrer, D. N. Engl. J. Med. (1982) [Pubmed]
  14. The course of patients with suspected myocardial infarction. The identification of low-risk patients for early transfer from intensive care. Mulley, A.G., Thibault, G.E., Hughes, R.A., Barnett, G.O., Reder, V.A., Sherman, E.L. N. Engl. J. Med. (1980) [Pubmed]
  15. A comparison of digoxin and dobutamine in patients with acute infarction and cardiac failure. Goldstein, R.A., Passamani, E.R., Roberts, R. N. Engl. J. Med. (1980) [Pubmed]
  16. Diltiazem and reinfarction in patients with non-Q-wave myocardial infarction. Results of a double-blind, randomized, multicenter trial. Gibson, R.S., Boden, W.E., Theroux, P., Strauss, H.D., Pratt, C.M., Gheorghiade, M., Capone, R.J., Crawford, M.H., Schlant, R.C., Kleiger, R.E. N. Engl. J. Med. (1986) [Pubmed]
  17. Coronary vasospasm as a possible cause of myocardial infarction. A conclusion derived from the study of "preinfarction" angina. Maseri, A., L'Abbate, A., Baroldi, G., Chierchia, S., Marzilli, M., Ballestra, A.M., Severi, S., Parodi, O., Biagini, A., Distante, A., Pesola, A. N. Engl. J. Med. (1978) [Pubmed]
  18. A long-term prevention study with oxprenolol in coronary heart disease. Taylor, S.H., Silke, B., Ebbutt, A., Sutton, G.C., Prout, B.J., Burley, D.M. N. Engl. J. Med. (1982) [Pubmed]
  19. Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Chen, M., Ona, V.O., Li, M., Ferrante, R.J., Fink, K.B., Zhu, S., Bian, J., Guo, L., Farrell, L.A., Hersch, S.M., Hobbs, W., Vonsattel, J.P., Cha, J.H., Friedlander, R.M. Nat. Med. (2000) [Pubmed]
  20. Estrogen stimulates microglia and brain recovery from hypoxia-ischemia in normoglycemic but not diabetic female mice. Zhang, L., Nair, A., Krady, K., Corpe, C., Bonneau, R.H., Simpson, I.A., Vannucci, S.J. J. Clin. Invest. (2004) [Pubmed]
  21. Genetic polymorphisms of apolipoprotein C-III and insulin in survivors of myocardial infarction. Ferns, G.A., Stocks, J., Ritchie, C., Galton, D.J. Lancet (1985) [Pubmed]
  22. Increased plasma levels of brain natriuretic peptide in patients with acute myocardial infarction. Morita, E., Yasue, H., Yoshimura, M., Ogawa, H., Jougasaki, M., Matsumura, T., Mukoyama, M., Nakao, K. Circulation (1993) [Pubmed]
  23. Survival after an experimental myocardial infarction: beneficial effects of long-term therapy with captopril. Pfeffer, M.A., Pfeffer, J.M., Steinberg, C., Finn, P. Circulation (1985) [Pubmed]
  24. Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions. Wahlestedt, C., Golanov, E., Yamamoto, S., Yee, F., Ericson, H., Yoo, H., Inturrisi, C.E., Reis, D.J. Nature (1993) [Pubmed]
  25. Steroid administration after myocardial infarction promotes early infarct expansion. A study in the rat. Mannisi, J.A., Weisman, H.F., Bush, D.E., Dudeck, P., Healy, B. J. Clin. Invest. (1987) [Pubmed]
  26. Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury. Chou, W.H., Choi, D.S., Zhang, H., Mu, D., McMahon, T., Kharazia, V.N., Lowell, C.A., Ferriero, D.M., Messing, R.O. J. Clin. Invest. (2004) [Pubmed]
  27. Infarction of intestine with massive amyloid deposition in two patients on long-term hemodialysis. Choi, H.S., Heller, D., Picken, M.M., Sidhu, G.S., Kahn, T. Gastroenterology (1989) [Pubmed]
  28. Letter: Infarction of fallopian tube after tubal diathermy. Cordiner, J.W., Carty, M.J., Mackay, D. Lancet (1976) [Pubmed]
  29. Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction. Ayach, B.B., Yoshimitsu, M., Dawood, F., Sun, M., Arab, S., Chen, M., Higuchi, K., Siatskas, C., Lee, P., Lim, H., Zhang, J., Cukerman, E., Stanford, W.L., Medin, J.A., Liu, P.P. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  30. Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Sirén, A.L., Fratelli, M., Brines, M., Goemans, C., Casagrande, S., Lewczuk, P., Keenan, S., Gleiter, C., Pasquali, C., Capobianco, A., Mennini, T., Heumann, R., Cerami, A., Ehrenreich, H., Ghezzi, P. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  31. Changes in the plasma levels of type 1 and type 2 plasminogen activator inhibitors in normal pregnancy and in patients with severe preeclampsia. Estellés, A., Gilabert, J., Aznar, J., Loskutoff, D.J., Schleef, R.R. Blood (1989) [Pubmed]
  32. Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction. Creemers, E., Cleutjens, J., Smits, J., Heymans, S., Moons, L., Collen, D., Daemen, M., Carmeliet, P. Am. J. Pathol. (2000) [Pubmed]
  33. Favorable left ventricular remodeling following large myocardial infarction by exercise training. Effect on ventricular morphology and gene expression. Orenstein, T.L., Parker, T.G., Butany, J.W., Goodman, J.M., Dawood, F., Wen, W.H., Wee, L., Martino, T., McLaughlin, P.R., Liu, P.P. J. Clin. Invest. (1995) [Pubmed]
  34. Diltiazem in acute myocardial infarction treated with thrombolytic agents: a randomised placebo-controlled trial. Incomplete Infarction Trial of European Research Collaborators Evaluating Prognosis post-Thrombolysis (INTERCEPT). Boden, W.E., van Gilst, W.H., Scheldewaert, R.G., Starkey, I.R., Carlier, M.F., Julian, D.G., Whitehead, A., Bertrand, M.E., Col, J.J., Pedersen, O.L., Lie, K.I., Santoni, J.P., Fox, K.M. Lancet (2000) [Pubmed]
  35. Early intravenous atenolol treatment in suspected acute myocardial infarction. Preliminary report of a randomised trial. Yusuf, S., Ramsdale, D., Peto, R., Furse, L., Bennett, D., Bray, C., Sleight, P. Lancet (1980) [Pubmed]
  36. Identification and differentiation of resting myocardial ischemia and infarction in man with positron computed tomography, 18F-labeled fluorodeoxyglucose and N-13 ammonia. Marshall, R.C., Tillisch, J.H., Phelps, M.E., Huang, S.C., Carson, R., Henze, E., Schelbert, H.R. Circulation (1983) [Pubmed]
  37. Increased occurrence of left ventricular thrombi during early treatment with timolol in patients with acute myocardial infarction. Johannessen, K.A., Nordrehaug, J.E., von der Lippe, G. Circulation (1987) [Pubmed]
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