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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Rat peritoneal mast cells release dipeptidyl peptidase II.

Purified rat peritoneal mast cells have a 10-20-fold higher dipeptidyl peptidase II (DPP II) activity as compared with that of macrophages from the same source. Upon stimulation with the secretagogue Compound 48/80, DPP II is released from peritoneal-lavage cells and from purified mast cells, but not from purified macrophages, in a dose-dependent manner. Maximally, about one-third of the DPP II present in peritoneal-lavage cells is released. Substance P and the antigen/IgE system probably produce a similar effect. Both histamine and Zn2+, two ingredients of mast-cell granules, strongly inhibit DPP II at concentrations reported to occur in the granules. A possible role of mast-cell DPP II in the remodelling of connective tissue is discussed.[1]


  1. Rat peritoneal mast cells release dipeptidyl peptidase II. Struckhoff, G., Heymann, E. Biochem. J. (1986) [Pubmed]
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