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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Growth hormone inhibition of glucagon- and cAMP-induced lipolysis by chicken adipose tissue in vitro.

The ability of growth hormone ( GH) to inhibit the early (first hour) lipolytic response to glucagon and cAMP was investigated using chicken adipose tissue explants in vitro. In the first hour of incubation, GH inhibited glucagon, 8-bromo-3',5'-cyclic adenosine monophosphate (8-bromo-cAMP), and 1-isobutyl-3-methyl-xanthine (IBMX) induced glycerol release. The antilipolytic effect of GH was dose dependent, with inhibition of glucagon and 8-bromo-cAMP observed in the presence of as little as 100 ng/ml GH. In the fourth hour of incubation (late lipolytic response), GH (10, 100, or 1000 ng/ml) enhanced the lipolytic action of glucagon.[1]

References

  1. Growth hormone inhibition of glucagon- and cAMP-induced lipolysis by chicken adipose tissue in vitro. Campbell, R.M., Scanes, C.G. Proc. Soc. Exp. Biol. Med. (1987) [Pubmed]
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