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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Porcine insulin-like growth factor (IGF) binding protein blocks IGF-I action on porcine adipose tissue.

A growth hormone-dependent insulin-like growth factor (IGF) binding protein (IGFBP) purified from porcine serum specifically blocked the acute insulin-like effects of IGF-I on lipogenesis and glucose oxidation in porcine adipose tissue. This inhibition was dose dependent with half-maximal effective concentrations of IGFBP of 530 ng/ml for lipogenesis and 590 ng/ml for glucose oxidation in the presence of 10(-8) M IGF-I. The IGFBP also caused decreased rates of lipogenesis following a 1-hr preincubation of tissue with IGF-I (10(-8) M). The IGFBP had no effect on insulin action on porcine adipose tissue. These findings demonstrate the inhibitory effects of a highly purified porcine serum IGFBP on the biologic effects of IGF-I in vitro, and provide evidence that the growth hormone-dependent IGFBP blocks the acute insulin-like actions of IGF-I in vivo.[1]

References

  1. Porcine insulin-like growth factor (IGF) binding protein blocks IGF-I action on porcine adipose tissue. Walton, P.E., Gopinath, R., Etherton, T.D. Proc. Soc. Exp. Biol. Med. (1989) [Pubmed]
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