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Gene Review

IGF1  -  insulin-like growth factor 1 (somatomedin C)

Sus scrofa

Synonyms: IGF-I, Npt2B
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Disease relevance of IGF1


Psychiatry related information on IGF1


High impact information on IGF1


Chemical compound and disease context of IGF1


Biological context of IGF1


Anatomical context of IGF1


Associations of IGF1 with chemical compounds

  • Alone, DHT had little effect on DNA synthesis, but significantly enhanced the mitogenic effects of OSFs or GDF9 in the presence of IGF1 [23].
  • The actions of insulin and somatomedin C (insulin-like growth factor I) on cholesterol side-chain cleavage activity and the synthesis of cytochrome P-450scc and adrenodoxin were investigated in primary cultures of swine ovarian (granulosa) cells [24].
  • Insulin-like growth factor I stimulates inositol phosphate accumulation, a rise in cytoplasmic free calcium, and proliferation in cultured porcine thyroid cells [15].
  • OBJECTIVE: To study the effects of growth hormone (GH) and insulinlike growth factor 1 (IGF-1) on whole body and gastrointestinal (GI), hepatic, femoral, and renal glutamine (GLN) uptake and release in septic piglets [2].
  • The inhibitor appears to consist of two IGF-binding proteins induced during vitamin C deficiency and starving and may be responsible for in vivo inhibition of collagen and proteoglycan synthesis [25].

Physical interactions of IGF1


Regulatory relationships of IGF1


Other interactions of IGF1


Analytical, diagnostic and therapeutic context of IGF1


  1. Transcriptional activation of the porcine P450 11A insulin-like growth factor response element in MCF-7 breast cancer cells. Urban, R.J., Bodenburg, Y. J. Biol. Chem. (1996) [Pubmed]
  2. Growth hormone and insulinlike growth factor 1 promote intestinal uptake and hepatic release of glutamine in sepsis. Balteskard, L., Unneberg, K., Mjaaland, M., Jenssen, T.G., Revhaug, A. Ann. Surg. (1998) [Pubmed]
  3. Attenuated in vitro coronary arteriolar vasorelaxation to insulin-like growth factor I in experimental hypercholesterolemia. Hasdai, D., Nielsen, M.F., Rizza, R.A., Holmes, D.R., Richardson, D.M., Cohen, P., Lerman, A. Hypertension (1999) [Pubmed]
  4. Insulin-like growth factor binding proteins modulate Müller cell responses to insulin-like growth factors. King, J.L., Guidry, C. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  5. Vitamin C deficiency in guinea pigs differentially affects the expression of type IV collagen, laminin, and elastin in blood vessels. Mahmoodian, F., Peterkofsky, B. J. Nutr. (1999) [Pubmed]
  6. Local action of phosphate depletion and insulin-like growth factor 1 on in vitro production of 1,25-dihydroxyvitamin D by cultured mammalian kidney cells. Condamine, L., Menaa, C., Vrtovsnik, F., Vztovsnik, F., Friedlander, G., Garabédian, M. J. Clin. Invest. (1994) [Pubmed]
  7. Blocking ligand occupancy of the alphaVbeta3 integrin inhibits insulin-like growth factor I signaling in vascular smooth muscle cells. Zheng, B., Clemmons, D.R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  8. Porcine aortic smooth muscle cells secrete a serine protease for insulin-like growth factor binding protein-2. Gockerman, A., Clemmons, D.R. Circ. Res. (1995) [Pubmed]
  9. Regulation of vascular smooth muscle cell responses to insulin-like growth factor (IGF)-I by local IGF-binding proteins. Hsieh, T., Gordon, R.E., Clemmons, D.R., Busby, W.H., Duan, C. J. Biol. Chem. (2003) [Pubmed]
  10. Depletion of insulin in streptozocin-induced-diabetic pigs alters estradiol, insulin-like growth factor (IGF)-I and IGF binding proteins in cultured ovarian follicles. Edwards, J.L., Hughey, T.C., Moore, A.B., Cox, N.M. Biol. Reprod. (1996) [Pubmed]
  11. Serum IgA-promoting effects induced by feed loads containing isolated deoxynivalenol (DON) in growing piglets. Drochner, W., Schollenberger, M., Piepho, H.P., Götz, S., Lauber, U., Tafaj, M., Klobasa, F., Weiler, U., Claus, R., Steffl, M. J. Toxicol. Environ. Health Part A (2004) [Pubmed]
  12. Treatment with growth hormone and insulin-like growth factor-1 in septicemia: effects on carbohydrate metabolism. Balteskard, L., Unneberg, K., Mjaaland, M., Sager, G., Jenssen, T.G., Revhaug, A. European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes. (1998) [Pubmed]
  13. Nucleotide sequence of porcine insulin-like growth factor. 1:5' untranslated region, exons 1 and 2 and mRNA. Müller, M., Brem, G. Nucleic Acids Res. (1990) [Pubmed]
  14. Insulin-like growth factor-I increases expression of the porcine P-450 cholesterol side chain cleavage gene through a GC-rich domain. Urban, R.J., Shupnik, M.A., Bodenburg, Y.H. J. Biol. Chem. (1994) [Pubmed]
  15. Insulin-like growth factor I stimulates inositol phosphate accumulation, a rise in cytoplasmic free calcium, and proliferation in cultured porcine thyroid cells. Takasu, N., Takasu, M., Komiya, I., Nagasawa, Y., Asawa, T., Shimizu, Y., Yamada, T. J. Biol. Chem. (1989) [Pubmed]
  16. Glycosylation defects alter insulin but not insulin-like growth factor I binding to Chinese hamster ovary cells. Podskalny, J.M., Rouiller, D.G., Grunberger, G., Baxter, R.C., McElduff, A., Gorden, P. J. Biol. Chem. (1986) [Pubmed]
  17. Similar control mechanisms regulate the insulin and type I insulin-like growth factor receptor kinases. Affinity-purified insulin-like growth factor I receptor kinase is activated by tyrosine phosphorylation of its beta subunit. Yu, K.T., Peters, M.A., Czech, M.P. J. Biol. Chem. (1986) [Pubmed]
  18. Variables controlling the secretion of a somatomedin-like peptide by cultured porcine smooth muscle cells. Clemmons, D.R. Circ. Res. (1985) [Pubmed]
  19. Transforming growth factor beta 1 stimulates inorganic pyrophosphate elaboration by porcine cartilage. Rosenthal, A.K., Cheung, H.S., Ryan, L.M. Arthritis Rheum. (1991) [Pubmed]
  20. Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions. Busby, W.H., Klapper, D.G., Clemmons, D.R. J. Biol. Chem. (1988) [Pubmed]
  21. Discrete alterations of the insulin-like growth factor I molecule which alter its affinity for insulin-like growth factor-binding proteins result in changes in bioactivity. Clemmons, D.R., Cascieri, M.A., Camacho-Hubner, C., McCusker, R.H., Bayne, M.L. J. Biol. Chem. (1990) [Pubmed]
  22. Insulin stimulates transepithelial sodium transport by activation of a protein phosphatase that increases Na-K ATPase activity in endometrial epithelial cells. Deachapunya, C., Palmer-Densmore, M., O'Grady, S.M. J. Gen. Physiol. (1999) [Pubmed]
  23. Androgens augment the mitogenic effects of oocyte-secreted factors and growth differentiation factor 9 on porcine granulosa cells. Hickey, T.E., Marrocco, D.L., Amato, F., Ritter, L.J., Norman, R.J., Gilchrist, R.B., Armstrong, D.T. Biol. Reprod. (2005) [Pubmed]
  24. The insulin-like growth factor, somatomedin C, induces the synthesis of cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin in ovarian cells. Veldhuis, J.D., Rodgers, R.J., Dee, A., Simpson, E.R. J. Biol. Chem. (1986) [Pubmed]
  25. Ascorbate requirement for hydroxylation and secretion of procollagen: relationship to inhibition of collagen synthesis in scurvy. Peterkofsky, B. Am. J. Clin. Nutr. (1991) [Pubmed]
  26. Thrombospondin and osteopontin bind to insulin-like growth factor (IGF)-binding protein-5 leading to an alteration in IGF-I-stimulated cell growth. Nam, T.J., Busby, W.H., Rees, C., Clemmons, D.R. Endocrinology (2000) [Pubmed]
  27. Differential steroidogenic response of subpopulations of porcine granulosa cells to insulin-like growth factor-1 (IGF-1) or IGF-1 analogs. Howard, H.J., Ford, J.J. Biol. Reprod. (1994) [Pubmed]
  28. Gonadotropin and cAMP modulation of IGE binding protein production in ovarian granulosa cells. Grimes, R.W., Samaras, S.E., Barber, J.A., Shimasaki, S., Ling, N., Hammond, J.M. Am. J. Physiol. (1992) [Pubmed]
  29. Concerted regulation of the porcine steroidogenic acute regulatory protein gene promoter activity by follicle-stimulating hormone and insulin-like growth factor I in granulosa cells involves GATA-4 and CCAAT/enhancer binding protein beta. LaVoie, H.A., Singh, D., Hui, Y.Y. Endocrinology (2004) [Pubmed]
  30. Expression of cartilage intermediate layer protein/nucleotide pyrophosphohydrolase parallels the production of extracellular inorganic pyrophosphate in response to growth factors and with aging. Hirose, J., Masuda, I., Ryan, L.M. Arthritis Rheum. (2000) [Pubmed]
  31. Concomitant effects of growth hormone on secretion of insulin-like growth factor I and progesterone by cultured porcine granulosa cells. Hsu, C.J., Hammond, J.M. Endocrinology (1987) [Pubmed]
  32. Concerted regulation of low density lipoprotein receptor gene expression by follicle-stimulating hormone and insulin-like growth factor I in porcine granulosa cells: promoter activation, messenger ribonucleic acid stability, and sterol feedback. LaVoie, H.A., Garmey, J.C., Day, R.N., Veldhuis, J.D. Endocrinology (1999) [Pubmed]
  33. Prevention of IGF-1 and TGFbeta stimulated type II collagen and decorin expression by bFGF and identification of IGF-1 mRNA transcripts in articular chondrocytes. Sonal, D. Matrix Biol. (2001) [Pubmed]
  34. Insulin and insulin-like growth factors (IGFs) stimulate production of IGF-binding proteins by ovarian granulosa cells. Grimes, R.W., Hammond, J.M. Endocrinology (1992) [Pubmed]
  35. IGF2 antisense transcript expression in porcine postnatal muscle is affected by a quantitative trait nucleotide in intron 3. Braunschweig, M.H., Van Laere, A.S., Buys, N., Andersson, L., Andersson, G. Genomics (2004) [Pubmed]
  36. Administration of ACTH to restrained, pregnant sows alters their pigs' hypothalamic-pituitary-adrenal (HPA) axis. Haussmann, M.F., Carroll, J.A., Weesner, G.D., Daniels, M.J., Matteri, R.L., Lay, D.C. J. Anim. Sci. (2000) [Pubmed]
  37. Transglutaminase activity in aging articular chondrocytes and articular cartilage vesicles. Rosenthal, A.K., Derfus, B.A., Henry, L.A. Arthritis Rheum. (1997) [Pubmed]
  38. Selective expression of insulin-like growth factor system components during porcine ovary follicular selection. Zhou, J., Adesanya, O.O., Vatzias, G., Hammond, J.M., Bondy, C.A. Endocrinology (1996) [Pubmed]
  39. Production of insulin-like growth factor binding proteins (IGFBPs) by porcine granulosa cells: identification of IGFBP-2 and -3 and regulation by hormones and growth factors. Mondschein, J.S., Smith, S.A., Hammond, J.M. Endocrinology (1990) [Pubmed]
  40. Porcine ovarian granulosa cells secrete insulin-like growth factor-binding proteins-4 and -5 and express their messenger ribonucleic acids: regulation by follicle-stimulating hormone and insulin-like growth factor-1. Grimes, R.W., Barber, J.A., Shimasaki, S., Ling, N., Hammond, J.M. Biol. Reprod. (1994) [Pubmed]
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