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Gene Review

IGFBP1  -  insulin-like growth factor binding protein 1

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Disease relevance of IGFBP1

  • IGF binding protein (BP) activity was affected by diabetes mellitus, with untreated diabetic pigs having greater IGFBP-1 activity in medium and with both diabetic groups having greater IGFBP-2 activity in follicular fluid (p < 0.05) [1].
  • Concentrations of IGF-BP did not change in porcine serum following acute challenges with pGH (10-1000 micrograms/kg body weight) or IGF-I (4 or 8 mg per pig) [2].
  • Finally, IGFBP-1 and -2 may have different roles during chronic undernutrition compared with unrestrained nutrition in adult life [3].
  • IGFBP-1 and -2 were negatively correlated to weight gain and food conversion efficiency in the ad libitum-fed group, while IGF-I, -II, IGFBP-1, -3 and -4 were positively correlated to body weight, weight gain and food conversion efficiency in the food-restricted group [3].
  • Fetal weight was positively associated with maternal circulating IGF-II and negatively associated with maternal circulating IGFBP-1 and -2 [4].

High impact information on IGFBP1


Biological context of IGFBP1


Anatomical context of IGFBP1


Associations of IGFBP1 with chemical compounds

  • In conclusion, estradiol was most related to size of the follicle; however, lowering of IGF-I regardless of follicle diameter and alterations in IGFBP activity suggest that diabetes affects IGF-I and its binding proteins differently from estradiol production [1].
  • Neither immunoneutralization of IGF-I nor OT substantially prevented the effects of GH on progesterone, IGFBP and PGE [16].
  • The IGFBP protease activity of ULF may therefore comprise a group of enzymes including an unidentified serine protease [17].
  • A large body of evidence suggests the existence of an intratesticular IGF system complete with ligands, receptors and binding proteins (IGFBPs); the aim of the present study was to evaluate tri-iodothyronine (T(3)) and retinoic acid (RA) effects on IGFBP production by Sertoli cells [18].
  • Follicular fluid (FF) was collected from individual follicles; IGF-I and steroid hormone concentrations were determined by radioimmunoassay, and IGF-binding protein (IGFBP) expression was assessed by Western ligand blotting [19].

Physical interactions of IGFBP1

  • During the final 48 h of culture, weakly associated cells produced greater quantities of 28-30-kDa IGFBP than did tightly bound cells in response to IGF-1 or analogs (both experiments; p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)[13]

Regulatory relationships of IGFBP1

  • Growth hormone treatment stimulated secretion of each IGFBP by 47 +/- 4.7, 46 +/- 10.2, 70 +/- 13.2, and 49 +/- 5.6%, respectively, over control levels [20].

Other interactions of IGFBP1

  • Inhibitory as well as stimulating controls of IGFBP-1 and -3 on IGF functions are discussed, which may maintain a balance between autocrine growth promoting activities of IGF-I and IGF1R [21].
  • In uterine flushes, relaxin treatment increased an IGFBP doublet (33 and 34.5 kDa) and IGFBP-3 [22].
  • However, in the presence of epidermal growth factor (which was without independent effect on the 30-kDa IGFBP), insulin also induced this 30-kDa IGFBP [23].
  • Cultures were stained for morphological analysis and conditioned media were collected for IGF-1 determination by radioimmunoassay (RIA) and IGFBP analysis by Western blotting [24].
  • In this study, we measured the effects of IGF-I, bFGF, and TGF-beta1 on IGFBP production by primary porcine satellite cell (PSC) cultures after first determining physiologically active concentrations of these growth factors to use according to [3H]thymidine incorporation dose responses [25].

Analytical, diagnostic and therapeutic context of IGFBP1


  1. Depletion of insulin in streptozocin-induced-diabetic pigs alters estradiol, insulin-like growth factor (IGF)-I and IGF binding proteins in cultured ovarian follicles. Edwards, J.L., Hughey, T.C., Moore, A.B., Cox, N.M. Biol. Reprod. (1996) [Pubmed]
  2. Effects of porcine growth hormone and insulin-like growth factor-I (IGF-I) on immunoreactive IGF-binding protein concentration in pigs. Walton, P.E., Etherton, T.D. J. Endocrinol. (1989) [Pubmed]
  3. Effects of acute and chronic food restriction on the insulin-like growth factor axis in the guinea pig. Sohlström, A., Katsman, A., Kind, K.L., Grant, P.A., Owens, P.C., Robinson, J.S., Owens, J.A. J. Endocrinol. (1998) [Pubmed]
  4. Food restriction alters pregnancy-associated changes in IGF and IGFBP in the guinea pig. Sohlström, A., Katsman, A., Kind, K.L., Roberts, C.T., Owens, P.C., Robinson, J.S., Owens, J.A. Am. J. Physiol. (1998) [Pubmed]
  5. Insulin-like growth factor-I (IGF-I) regulates IGF-binding protein-5 synthesis through transcriptional activation of the gene in aortic smooth muscle cells. Duan, C., Hawes, S.B., Prevette, T., Clemmons, D.R. J. Biol. Chem. (1996) [Pubmed]
  6. Insulin-like growth factor binding proteins modulate Müller cell responses to insulin-like growth factors. King, J.L., Guidry, C. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  7. Role of insulin-like growth factor binding protein (IGFBP)-3 in TGF-beta- and GDF-8 (myostatin)-induced suppression of proliferation in porcine embryonic myogenic cell cultures. Kamanga-Sollo, E., Pampusch, M.S., White, M.E., Dayton, W.R. J. Cell. Physiol. (2003) [Pubmed]
  8. Effect of glucose on insulin-like growth factor binding protein-4 proteolysis. Jacot, T.A., Clemmons, D.R. Endocrinology (1998) [Pubmed]
  9. Evidence for an in vivo role of insulin-like growth factor-binding protein-1 and -2 as inhibitors of collagen gene expression in vitamin C-deficient and fasted guinea pigs. Gosiewska, A., Wilson, S., Kwon, D., Peterkofsky, B. Endocrinology (1994) [Pubmed]
  10. Assignment of the gene for porcine insulin-like growth factor binding protein 1 to chromosome 18 and detection of polymorphisms in intron 2 by PCR-RFLP. Inage-Miyake, Y., Shimanuki, S., Itoh, T., Murakami, Y., Kimura, M., Suzuki, H., Miyake, M., Toki, D., Uenishi, H., Awata, T., Hamasima, N. Biochem. Genet. (2005) [Pubmed]
  11. The effects of thyroxine on serum and tissue concentrations of insulin-like growth factors (IGF-I and -II) and IGF-binding proteins in the fetal pig. Latimer, A.M., Hausman, G.J., McCusker, R.H., Buonomo, F.C. Endocrinology (1993) [Pubmed]
  12. Porcine insulin-like growth factor (IGF) binding protein blocks IGF-I action on porcine adipose tissue. Walton, P.E., Gopinath, R., Etherton, T.D. Proc. Soc. Exp. Biol. Med. (1989) [Pubmed]
  13. Differential steroidogenic response of subpopulations of porcine granulosa cells to insulin-like growth factor-1 (IGF-1) or IGF-1 analogs. Howard, H.J., Ford, J.J. Biol. Reprod. (1994) [Pubmed]
  14. Insulin-like growth factors and insulin-like growth factor binding proteins in porcine serum and milk throughout lactation. Donovan, S.M., McNeil, L.K., Jiménez-Flores, R., Odle, J. Pediatr. Res. (1994) [Pubmed]
  15. Factors affecting production of luciferase and epitope-tagged IGF-I in porcine muscle after DNA injection. Everett, R.S., Gerrard, D.E., Grant, A.L. J. Endocrinol. (2000) [Pubmed]
  16. Do GH, IGF-I and oxytocin interact by regulating the secretory activity of porcine ovarian cells? Sirotkin, A.V., Makarevich, A.V., Kwon, H.B., Kotwica, J., Bulla, J., Hetényi, L. J. Endocrinol. (2001) [Pubmed]
  17. Proteolysis of insulin-like growth factor-binding proteins (IGFBPs) within the pig uterine lumen associated with peri-implantation conceptus development. Lee, C.Y., Green, M.L., Simmen, R.C., Simmen, F.A. J. Reprod. Fertil. (1998) [Pubmed]
  18. Thyroid hormone and retinoic acid induce the synthesis of insulin-like growth factor-binding protein-4 in prepubertal pig sertoli cells. Bardi, G., Bottazzi, C., Demori, I., Palmero, S. Eur. J. Endocrinol. (1999) [Pubmed]
  19. ACTH treatment disrupts ovarian IGF-I and steroid hormone production. Viveiros, M.M., Liptrap, R.M. J. Endocrinol. (2000) [Pubmed]
  20. Hormonal regulation of insulin-like growth factor binding proteins and insulin-like growth factor I (IGF-I) secretion in porcine stromal-vascular cultures. Chen, N.X., Hausman, G.J., Wright, J.T. J. Anim. Sci. (1996) [Pubmed]
  21. Immunohistochemical detection of components of the insulin-like growth factor system during skeletal muscle growth in the pig. Götz, W., Dittjen, O., Wicke, M., Biereder, S., Krüger, U., von Lengerken, G. Anatomia, histologia, embryologia. (2001) [Pubmed]
  22. Relaxin increases insulin-like growth factors (IGFs) and IGF-binding proteins of the pig uterus in vivo. Ohleth, K.M., Lenhart, J.A., Ryan, P.L., Radecki, S.V., Bagnell, C.A. Endocrinology (1997) [Pubmed]
  23. Insulin and insulin-like growth factors (IGFs) stimulate production of IGF-binding proteins by ovarian granulosa cells. Grimes, R.W., Hammond, J.M. Endocrinology (1992) [Pubmed]
  24. Influence of thyroxine in vivo on preadipocyte development and insulin-like growth factor-I and IGF binding protein secretion in fetal stromal vascular cell cultures. Chen, N.X., Hausman, G.J., Wright, J.T. Obes. Res. (1996) [Pubmed]
  25. Effects of growth factors on insulin-like growth factor binding protein (IGFBP) secretion by primary porcine satellite cell cultures. Yi, Z., Hathaway, M.R., Dayton, W.R., White, M.E. J. Anim. Sci. (2001) [Pubmed]
  26. Altered expression of IGFs and IGF-binding proteins during intrauterine growth restriction in guinea pigs. Carter, A.M., Kingston, M.J., Han, K.K., Mazzuca, D.M., Nygard, K., Han, V.K. J. Endocrinol. (2005) [Pubmed]
  27. Increases in insulin-like growth factor binding protein-2 accompany decreases in proliferation and differentiation when porcine muscle satellite cells undergo multiple passages. Fligger, J.M., Malven, P.V., Doumit, M.E., Merkel, R.A., Grant, A.L. J. Anim. Sci. (1998) [Pubmed]
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