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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Mechanism of induction of long term potentiation by the mast cell degranulating peptide.

The properties of Long Term Potentiation (LTP), which is a sustained enhancement of the synaptic response produced by a brief train of electrical stimulation, and its mechanisms are briefly reviewed. Bath application of the mast cell degranulating peptide (MCD) - a peptide isolated from bee venom- also produces in hippocampal slices LTP which is indistinguishable from that produced by a train of electrical stimulation (no change in postsynaptic cell properties, APV sensitive). In vivo push-pull experiments indicate that this LTP is not associated with a sustained enhancement of release of glutamate and aspartate, the two principle transmitters of the hippocampus, but there is a delayed enhanced release of proteins in the extracellular space which may contribute to the maintenance of the potentiation.[1]

References

  1. Mechanism of induction of long term potentiation by the mast cell degranulating peptide. Ben Ari, Y., Cherubini, E., Aniksztejn, L., Roisin, M.P., Charriaut-Marlangue, C. Pharmacopsychiatry (1989) [Pubmed]
 
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