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Gene Review

Mcdp  -  mast cell-degranulating peptide

Apis mellifera

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Disease relevance of Mcdp


High impact information on Mcdp


Biological context of Mcdp


Anatomical context of Mcdp


Associations of Mcdp with chemical compounds


Other interactions of Mcdp


Analytical, diagnostic and therapeutic context of Mcdp

  • Autoradiography has shown that a high enough dendrotoxin I concentration (30 nM) prevented binding of 125I MCD peptide to all brain structures where specific receptors had been identified [17].
  • Bath application of the mast cell degranulating peptide (MCD) - a peptide isolated from bee venom- also produces in hippocampal slices LTP which is indistinguishable from that produced by a train of electrical stimulation (no change in postsynaptic cell properties, APV sensitive) [18].
  • The precursors of mast cell degranulating peptide (MCDP) genes were amplified by RT-PCR from the total RNA of venom gland of two honeybee species, Apis mellifera ligustica, Apis cerana cerana, and three wasp species, Vespa magnifica, Vespa velutina nigrothorax and Polistes hebraeus, respectively [19].


  1. Inflammatory role of two venom components of yellow jackets (Vespula vulgaris): a mast cell degranulating peptide mastoparan and phospholipase A1. King, T.P., Jim, S.Y., Wittkowski, K.M. Int. Arch. Allergy Immunol. (2003) [Pubmed]
  2. Long-term potentiation of synaptic transmission in the hippocampus induced by a bee venom peptide. Cherubini, E., Ben Ari, Y., Gho, M., Bidard, J.N., Lazdunski, M. Nature (1987) [Pubmed]
  3. Purification and subunit structure of a putative K+-channel protein identified by its binding properties for dendrotoxin I. Rehm, H., Lazdunski, M. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  4. Comparable 30-kDa apamin binding polypeptides may fulfill equivalent roles within putative subtypes of small conductance Ca(2+)-activated K+ channels. Wadsworth, J.D., Doorty, K.B., Strong, P.N. J. Biol. Chem. (1994) [Pubmed]
  5. The characterization of high-affinity binding sites in rat brain for the mast cell-degranulating peptide from bee venom using the purified monoiodinated peptide. Taylor, J.W., Bidard, J.N., Lazdunski, M. J. Biol. Chem. (1984) [Pubmed]
  6. Mast cell degranulating peptide: a multi-functional neurotoxin. Ziai, M.R., Russek, S., Wang, H.C., Beer, B., Blume, A.J. J. Pharm. Pharmacol. (1990) [Pubmed]
  7. K+ channel involvement in induction of synaptic enhancement by mast cell degranulating (MCD) peptide. Kondo, T., Ikenaka, K., Fujimoto, I., Aimoto, S., Kato, H., Ito, K., Taguchi, T., Morita, T., Kasai, M., Mikoshiba, K. Neurosci. Res. (1992) [Pubmed]
  8. A K+ channel in Xenopus nerve fibres selectively blocked by bee and snake toxins: binding and voltage-clamp experiments. Bräu, M.E., Dreyer, F., Jonas, P., Repp, H., Vogel, W. J. Physiol. (Lond.) (1990) [Pubmed]
  9. Amino acid sequence of bumblebee MCD peptide: a new mast cell degranulating peptide from the venom of the bumblebee Megabombus pennsylvanicus. Argiolas, A., Herring, P., Pisano, J.J. Peptides (1985) [Pubmed]
  10. Mast cell degranulating peptide induces the expression of the c-fos proto-oncogene in hippocampus. Séquier, J.M., Lazdunski, M. Eur. J. Pharmacol. (1990) [Pubmed]
  11. Mast cell degranulating peptide and dendrotoxin selectively inhibit a fast-activating potassium current and bind to common neuronal proteins. Stansfeld, C.E., Marsh, S.J., Parcej, D.N., Dolly, J.O., Brown, D.A. Neuroscience (1987) [Pubmed]
  12. Inhibition of beta-bungarotoxin binding to brain membranes by mast cell degranulating peptide, toxin I, and ethylene glycol bis (beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid. Schmidt, R.R., Betz, H., Rehm, H. Biochemistry (1988) [Pubmed]
  13. Further studies on the structural requirements for polypeptide-mediated histamine release from rat mast cells. Jasani, B., Kreil, G., Mackler, B.F., Stanworth, D.R. Biochem. J. (1979) [Pubmed]
  14. Inhibition of prostaglandin biosynthesis by the mast-cell-degranulating agent compound 48/80 but not by the mast-cell-degranulating peptide (peptide-401) from bee venom. Dempsey, C.E., Banks, B.E., Roberts, N.A., Vernon, C.A. Biochem. Pharmacol. (1985) [Pubmed]
  15. Characteristics of histamine secretion induced by neuropeptides: implications for the relevance of peptide-mast cell interactions in allergy and inflammation. Pearce, F.L., Kassessinoff, T.A., Liu, W.L. Int. Arch. Allergy Appl. Immunol. (1989) [Pubmed]
  16. A comparative structural study of apamin and related bee venom peptides. Hider, R.C., Ragnarsson, U. Biochim. Biophys. Acta (1981) [Pubmed]
  17. Two potent central convulsant peptides, a bee venom toxin, the MCD peptide, and a snake venom toxin, dendrotoxin I, known to block K+ channels, have interacting receptor sites. Bidard, J.N., Mourre, C., Lazdunski, M. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  18. Mechanism of induction of long term potentiation by the mast cell degranulating peptide. Ben Ari, Y., Cherubini, E., Aniksztejn, L., Roisin, M.P., Charriaut-Marlangue, C. Pharmacopsychiatry (1989) [Pubmed]
  19. Cloning and characterization analysis of the genes encoding precursor of mast cell degranulating peptide from 2 honeybee and 3 wasp species. Zhang, S.F., Shi, W.J., Cheng, J.A., Zhang, C.X. Yi Chuan Xue Bao (2003) [Pubmed]
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