The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Metabolism of organonitriles to cyanide by rat nasal tissue enzymes.

1. A method for determination of cyanide release during microsomal metabolism of organonitriles was developed. 2. Vmax values for cyanide release from acetonitrile, propionitrile, butyronitrile, isobutyronitrile, acrylonitrile, benzyl cyanide and succinonitrile were determined for rat nasal and liver microsomal metabolism. 3. Km and Vmax values were determined for nasal and liver microsomal metabolism of benzyl cyanide to cyanide. 4. Vmax values were all greater in nasal microsomes than in liver microsomes. Except for acrylonitrile, butyronitrile and isobutyronitrile metabolism, the ethmoturbinate microsomes had higher activities than the maxilloturbinate microsomes. 5. Two methods for determining Vmax values indicate that rat liver, but not the nose, contains at least two cytochrome P-450 isozymes involved in metabolism of benzyl cyanide to cyanide. 6. These results, and previously reported nasal rhodanese activity data, indicate that inhaled organonitriles are substantially detoxicated in the nasal cavity.[1]


  1. Metabolism of organonitriles to cyanide by rat nasal tissue enzymes. Dahl, A.R., Waruszewski, B.A. Xenobiotica (1989) [Pubmed]
WikiGenes - Universities