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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Antibiotic prophylaxis in acute nonperforated appendicitis. The Danish Multicenter Study Group III.

In a prospective, block-randomized, multicenter study, the safety and efficacy of cefoxitin in preoperative prophylaxis were studied. 1735 patients undergoing appendectomy were evaluable, and half of these patients received 2 g of cefoxitin before undergoing operation. The patients were divided into three groups: patients with a normal appendix, patients with an acutely inflamed appendix, and patients with a gangrenous appendix. The study showed for each group a significant reduction of the incidence of wound infection in patients receiving prophylaxis. However, intra-abdominal abscess formation was not influenced by preoperative antibiotic prophylaxis. Consequently, routine preoperative prophylaxis is recommended before appendectomy.[1]

References

  1. Antibiotic prophylaxis in acute nonperforated appendicitis. The Danish Multicenter Study Group III. Bauer, T., Vennits, B., Holm, B., Hahn-Pedersen, J., Lysen, D., Galatius, H., Kristensen, E.S., Graversen, P., Wilhelmsen, F., Skjoldborg, H. Ann. Surg. (1989) [Pubmed]
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