Disease relevance of Appendectomy

• Primary appendectomy. The effect of prophylatic cephaloridine on postoperative wound infection [1].
• During childhood thrombosis prophylaxis cannot be regularly recommended but should be instituted after 13 years of age during/after abdominal surgery, including appendectomy, and after leg injury in AT-III-, PC-, and PS-deficient patients [2].
• In 1992, of 8268114 procedures, appendectomy represented 4.15%; hernia, 4.09%; varicose veins, 3.61%; and cholecystectomy, 1.82% [3].
• Combined preoperative antibiotic therapy and intraoperative topical povidone-iodine. Reduction of wound sepsis following emergency appendectomy [4].
• Treatment of gangrenous and perforated appendicitis consisted of administration of ampicillin sodium, gentamicin sulfate, and clindamycin phosphate; appendectomy; and saline peritoneal irrigation [5].

High impact information on Appendectomy

• Chronic ANP suppression was produced by bilateral atrial appendectomies before the production of ELVD by rapid ventricular pacing (ELVD-APPX, n = 5) [6].
• However, interleukin 4 production was below detectable levels both before and after appendectomy [7].
• Plasma vasopressin, measured at the end of volume expansion, was significantly lower in animals subjected to left atrial appendectomy [8].
• Duration of both parenteral and oral analgesic use favored laparoscopic appendectomy (2.0 days versus 1.2 days, and 8.0 days versus 5.4 days, p < 0.05) [9].
• 1735 patients undergoing appendectomy were evaluable, and half of these patients received 2 g of cefoxitin before undergoing operation [10].

Chemical compound and disease context of Appendectomy

• The effect of intravenous hyperalimentation with essential amino acids and hypertonic dextrose on nitrogen metabolism, total body urea and creatinine was studied in 16 patients with end-stage renal disease prior to and after bilateral nephrectomy, splenectomy and appendectomy [11].
• Prevention of postoperative wound infection after appendectomy by local application of tinidazole: a double-blind study [12].
• Management of wound infection after appendectomy: are parenteral antibiotics useful [13]?
• A controlled study of single dosage cefamandole in the prophylaxis of wound infections in appendectomy [14].
• A 7-year-old boy developed rhabdomyolysis with a peak creatine phosphokinase level of 261,400 IU/L after his appendectomy [15].

Biological context of Appendectomy

• In a study of wound healing at high altitude, subcutaneously implanted PTFE tubes were used to stimulate and measure accumulation of wound hydroxyproline (an index of collagen) in 26 patients who had appendectomy and in 38 patients who had cholecystectomy [16].
• Thus atrial natriuretic peptide can be used effectively in low doses to induce a diuresis after biatrial appendectomies [17].
• Plasma atrial natriuretic peptide and blood pressure during chronic salt loading in spontaneously hypertensive rats with right atrial appendectomy [18].
• Cefoxitin has been the prophylactic antibiotic of choice for appendectomy and colorectal surgery at this institution [19].
• These studies support the hypothesis that right atrial appendectomy in the rat attenuates acute volume expansion-induced increases in circulating ANP and urinary sodium excretion and that the natriuresis of acute volume expansion is mediated in part by an increase in circulating ANP [20].

Anatomical context of Appendectomy

• Because mucosal T-cell activity has an even more critical role in the pathogenesis of celiac disease, our objective was to determine whether the development or mode of presentation of this disorder is influenced by appendectomy and/or tonsillectomy [21].
• Atrial natriuretic peptide secretion and body fluid balance after bilateral atrial appendectomy by the maze procedure [22].
• The protocol included perioperative antibiotics of gentamicin and clindamycin, appendectomy through a muscle-splitting incision, irrigation of the peritoneal cavity with saline, and peritoneal drainage through the lateral aspect of the wound with skin closure [23].

Associations of Appendectomy with chemical compounds

• Two patients with intraperitoneal complications after appendectomy had a significantly increased urea production [24].
• Systemic prophylactic antibiotics can successfully reduce septic complications after appendectomy for nonperforated appendicitis, and a single drug (cefamandole) directed at the facultative pathogens is as effective as double drug therapy, which includes specific anaerobic coverage [25].
• Concentrations of cefmetazole in plasma and tissue resulting from peri-incisional administration before appendectomy [26].
• We conclude that measuring serotonin may be of value in confirming or excluding the diagnosis of early acute appendicitis where the physical signs are equivocal, and thus helps reduce unnecessary appendectomies [27].
• Similarly, when given intravenously prior to appendectomy, tinidazole reduced the incidence of postoperative infection in some subgroups of patients [28].

Gene context of Appendectomy

• The healthy father and brother were CARD15 R702W positive, were non-smokers and had not undergone appendectomy [29].
• To avoid these appalling troubles in general anesthesia, we chose spinal anesthesia for a patient with MELAS syndrome receiving appendectomy [30].
• Medical histories including inflammatory bowel disease, headaches, vertigo, tinnitus and anemia, as well as surgical tonsillectomies, appendectomies and cholecystectomies, were significantly greater in G1 and G2 when compared to G3 [31].
• The effect of selective right or left atrial appendectomy on atrial natriuretic factor (ANF) release was studied in the rat to compare the relative contribution of each atrium in a situation of increased afterload [32].
• In addition, presenting features, predefined in the study protocol, did not differ significantly in the appendectomy and nonappendectomy celiac patients [21].

Analytical, diagnostic and therapeutic context of Appendectomy

• To test whether anesthetics alter hemoglobin O2 affinity, venous blood was sampled from 27 healthy subjects before and during general anesthesia for appendectomy with halothane, enflurane, or nitrous oxide anesthesia [33].
• On day 0, appendectomy and peritoneal lavage were performed, ceftriaxone (250 mg, i.m./24 h.) was started and animals were randomly assigned to receive regular fluids (RF), glucose-based TPN (G-TPN) or isocaloric fat-based TPN (F-TPN) for 6 days [34].
• Concentrations of ampicillin after intraincisional instillation in laparotomy wounds were measured in ten patients undergoing appendectomy [35].
• A significant decrease of serum RF titer was also seen in patients with RA subjected to tonsillectomy, adenoidectomy and appendectomy [36].
• The possibility of an association between rheumatoid arthritis (RA) and prior tonsillectomy and appendectomy was investigated in a community based case-control study of 229 female cases of probable and definite RA and 458 appropriately matched controls [37].

References