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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Ketopantoyl lactone reductase is a conjugated polyketone reductase.

Ketopantoyl lactone reductase (EC of Saccharomyces cerevisiae was found to catalyze the reduction of a variety of natural and unnatural conjugated polyketone compounds and quinones, such as isatin, ninhydrin, camphorquinone and beta-naphthoquinone in the presence of NADPH. 5-Bromoisatin is the best substrate for the enzyme (Km = 3.1 mM; Vmax = 650 mumol/min/mg). The enzyme is inhibited by quercetin, and several polyketones. These results suggest that ketopantoyl lactone reductase is a carbonyl reductase which specifically catalyzes the reduction of conjugated polyketones.[1]


  1. Ketopantoyl lactone reductase is a conjugated polyketone reductase. Hata, H., Shimizu, S., Hattori, S., Yamada, H. FEMS Microbiol. Lett. (1989) [Pubmed]
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