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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Induction of labour after fetal death: a randomized controlled trial of two prostaglandin regimens.

A total of 85 women with antepartum fetal death between 14 and 42 weeks gestation was randomly assigned to one of two regimens of intravenous infusion of the prostaglandin analogue 16-phenoxy-17, 18, 19, 20-tetranor-PGE2-methylsulphonamide (sulprostone) for inducing labour. Women received either 1 microgram/min until delivery or the commonly recommended treatment of 1500 micrograms in 8 h followed by another, identical course of treatment if delivery did not occur within 24 h. The 1 microgram/min dose schedule used half the amount of prostaglandin and resulted in statistically significantly fewer gastrointestinal side-effects compared with the conventional treatment. All women were delivered vaginally and there were no differences in induction-to-delivery intervals between the two treatments. Sulprostone infused at a rate of 1 microgram/min resulted in a 50% chance of being delivered within 12 h and a 90% chance of being delivered within 24 h, with an overall frequency of side-effects of 20%.[1]


  1. Induction of labour after fetal death: a randomized controlled trial of two prostaglandin regimens. Kanhai, H.H., Keirse, M.J. British journal of obstetrics and gynaecology. (1989) [Pubmed]
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