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Chemical Compound Review

Nalador     (Z)-7-[(1R,2S,3R)-3-hydroxy- 2-[(E,3S)-3...

Synonyms: sulproston, Sulprostona, Sulprostone, Sulprostonum, SHB-286, ...
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Disease relevance of Nalador


High impact information on Nalador


Chemical compound and disease context of Nalador


Biological context of Nalador


Anatomical context of Nalador

  • Maintained in short-term cultures (i.e. 3.5 h) in a serum-free, defined medium, hepatocyte parenchymal cells underwent DNA synthesis and proliferation in the presence of sulprostone (10(-6) M), PGE(2) (10(-6) M), and 17-phenyl-trinor-PGE(2) (10(-9) M) in a time- and dose-dependent manner [20].
  • Potent, albeit nonselective, smooth-muscle stimulant activity has been previously reported for 16-phenoxy- and 17-phenylprostaglandins, a finding that led to the design and development of the tissue-selective uterine stimulant sulprostone [21].
  • In contrast, the EP(1 )agonist, sulprostone, had not effects on monocytes, indicating that the effects of PGE(2) are mediated by EP(2)/EP(4 )receptors [22].
  • 5. The EP1-/EP3-receptor selective agonist sulprostone and the EP3-receptor agonist enprostil produced potent contractile responses supporting the presence of contractile EP3-receptors in the non-pregnant human myometrium in vitro [23].
  • On guinea-pig trachea, L-798,106 also antagonised sulprostone-induced inhibition of EFS-induced twitch responses, with similar potency (mean pA(2)=7.82) [24].

Associations of Nalador with other chemical compounds


Gene context of Nalador


Analytical, diagnostic and therapeutic context of Nalador


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  2. Sulprostone-induced reduction of myocardial infarct size in the rabbit by activation of ATP-sensitive potassium channels. Hide, E.J., Thiemermann, C. Br. J. Pharmacol. (1996) [Pubmed]
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  4. Extracorporeal membrane oxygenation therapy for circulatory arrest due to postpartum hemorrhage. Reyftmann, L., Morau, E., Herve, D., Jean-Marc, F., Bernard, H. Obstetrics and gynecology. (2006) [Pubmed]
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  9. Regulation of expression of matrix metalloproteinase-9 in early human T cells of the HSB.2 cultured line by the EP3 subtype of prostaglandin E2 receptor. Zeng, L., An, S., Goetzl, E.J. J. Biol. Chem. (1996) [Pubmed]
  10. A prostaglandin E receptor coupled to a pertussis toxin-sensitive guanine nucleotide regulatory protein in rabbit cortical collecting tubule cells. Sonnenburg, W.K., Zhu, J.H., Smith, W.L. J. Biol. Chem. (1990) [Pubmed]
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  13. Third prize: Prostaglandin E(2)-3 receptor is involved in ureteral contractility in obstruction. Ankem, M.K., Jerde, T.J., Wilkinson, E.R., Nakada, S.Y. J. Endourol. (2005) [Pubmed]
  14. Diverse prostaglandin receptors activate distinct signal transduction pathways in rat myometrium. Goureau, O., Tanfin, Z., Marc, S., Harbon, S. Am. J. Physiol. (1992) [Pubmed]
  15. Altered growth response to prostaglandin E2 and its receptor signaling in mesangial cells from stroke-prone spontaneously hypertensive rats. Suganami, T., Tanaka, I., Mukoyama, M., Kotani, M., Muro, S., Mori, K., Goto, M., Ishibashi, R., Kasahara, M., Yahata, K., Makino, H., Sugawara, A., Nakao, K. J. Hypertens. (2001) [Pubmed]
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  17. Prostaglandins inhibit secretion of histamine and pancreastatin from isolated rat stomach ECL cells. Lindström, E., Håkanson, R. Br. J. Pharmacol. (1998) [Pubmed]
  18. Prostaglandin E2 induced caspase-dependent apoptosis possibly through activation of EP2 receptors in cultured hippocampal neurons. Takadera, T., Shiraishi, Y., Ohyashiki, T. Neurochem. Int. (2004) [Pubmed]
  19. Prostaglandin E2 enhances neurotrophin-4 production via EP3 receptor in human keratinocytes. Kanda, N., Koike, S., Watanabe, S. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  20. Prostaglandin E(2) (EP(1)) receptor agonist-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes: the involvement of TGF-alpha. Kimura, M., Osumi, S., Ogihara, M. Endocrinology (2001) [Pubmed]
  21. Structure-activity studies of configurationally rigid arylprostaglandins. Schaaf, T.K., Johnson, M.R., Constantine, J.W., Bindra, J.S., Hess, H.J., Elger, W. J. Med. Chem. (1983) [Pubmed]
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  24. E-ring 8-isoprostanes inhibit ACh release from parasympathetic nerves innervating guinea-pig trachea through agonism of prostanoid receptors of the EP3-subtype. Clarke, D.L., Giembycz, M.A., Patel, H.J., Belvisi, M.G. Br. J. Pharmacol. (2004) [Pubmed]
  25. Electrically evoked release of [(3)H]noradrenaline from mouse cultured sympathetic neurons: release-modulating heteroreceptors. Göbel, I., Trendelenburg, A.U., Cox, S.L., Meyer, A., Starke, K. J. Neurochem. (2000) [Pubmed]
  26. Morphological changes in the anterior eye segment after long-term treatment with different receptor selective prostaglandin agonists and a prostamide. Richter, M., Krauss, A.H., Woodward, D.F., Lütjen-Drecoll, E. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
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  28. Characterization of the prostanoid receptors mediating constriction and relaxation of human isolated uterine artery. Baxter, G.S., Clayton, J.K., Coleman, R.A., Marshall, K., Sangha, R., Senior, J. Br. J. Pharmacol. (1995) [Pubmed]
  29. Developmental regulation of endothelial nitric oxide synthase in cerebral vessels of newborn pig by prostaglandin E(2). Dumont, I., Hou, X., Hardy, P., Peri, K.G., Beauchamp, M., Najarian, T., Molotchnikoff, S., Varma, D.R., Chemtob, S. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  30. Mechanisms of prostaglandin E2-induced interleukin-6 release in astrocytes: possible involvement of EP4-like receptors, p38 mitogen-activated protein kinase and protein kinase C. Fiebich, B.L., Schleicher, S., Spleiss, O., Czygan, M., Hüll, M. J. Neurochem. (2001) [Pubmed]
  31. Molecular pharmacology of aromatase and its regulation by endogenous and exogenous agents. Brueggemeier, R.W., Richards, J.A., Joomprabutra, S., Bhat, A.S., Whetstone, J.L. J. Steroid Biochem. Mol. Biol. (2001) [Pubmed]
  32. Role of prostaglandin E receptor subtypes in gastroduodenal HCO3- secretion. Takeuchi, K., Aihara, E., Hayashi, M., Sasaki, Y. Medicinal chemistry (Sh⁻ariqah, United Arab Emirates) (2005) [Pubmed]
  33. Prostaglandin E2 (PGE2) autoamplifies its production through EP1 subtype of PGE receptor in mouse osteoblastic MC3T3-E1 cells. Suda, M., Tanaka, K., Yasoda, A., Natsui, K., Sakuma, Y., Tanaka, I., Ushikubi, F., Narumiya, S., Nakao, K. Calcif. Tissue Int. (1998) [Pubmed]
  34. A randomized comparison of oxytocin, sulprostone and placebo in the management of the third stage of labour. Poeschmann, R.P., Doesburg, W.H., Eskes, T.K. British journal of obstetrics and gynaecology. (1991) [Pubmed]
  35. Analysis of 369 abortions conducted by mifepristone (RU486) associated with sulprostone in a French family planning center. Thonneau, P., Fougeyrollas, B., Spira, A. Fertil. Steril. (1994) [Pubmed]
  36. Modulation of guinea pig intrinsic cardiac neurons by prostaglandins. Jelson, G.S., DeMasi, G.M., Sager, K.L., Hardwick, J.C. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2003) [Pubmed]
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