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Chemical Compound Review

Nalador     (Z)-7-[(1R,2S,3R)-3-hydroxy- 2-[(E,3S)-3...

Synonyms: sulproston, Sulprostona, Sulprostone, Sulprostonum, SHB-286, ...
 
 
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Disease relevance of Nalador

 

High impact information on Nalador

 

Chemical compound and disease context of Nalador

 

Biological context of Nalador

 

Anatomical context of Nalador

  • Maintained in short-term cultures (i.e. 3.5 h) in a serum-free, defined medium, hepatocyte parenchymal cells underwent DNA synthesis and proliferation in the presence of sulprostone (10(-6) M), PGE(2) (10(-6) M), and 17-phenyl-trinor-PGE(2) (10(-9) M) in a time- and dose-dependent manner [20].
  • Potent, albeit nonselective, smooth-muscle stimulant activity has been previously reported for 16-phenoxy- and 17-phenylprostaglandins, a finding that led to the design and development of the tissue-selective uterine stimulant sulprostone [21].
  • In contrast, the EP(1 )agonist, sulprostone, had not effects on monocytes, indicating that the effects of PGE(2) are mediated by EP(2)/EP(4 )receptors [22].
  • 5. The EP1-/EP3-receptor selective agonist sulprostone and the EP3-receptor agonist enprostil produced potent contractile responses supporting the presence of contractile EP3-receptors in the non-pregnant human myometrium in vitro [23].
  • On guinea-pig trachea, L-798,106 also antagonised sulprostone-induced inhibition of EFS-induced twitch responses, with similar potency (mean pA(2)=7.82) [24].
 

Associations of Nalador with other chemical compounds

 

Gene context of Nalador

 

Analytical, diagnostic and therapeutic context of Nalador

References

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  2. Sulprostone-induced reduction of myocardial infarct size in the rabbit by activation of ATP-sensitive potassium channels. Hide, E.J., Thiemermann, C. Br. J. Pharmacol. (1996) [Pubmed]
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  4. Extracorporeal membrane oxygenation therapy for circulatory arrest due to postpartum hemorrhage. Reyftmann, L., Morau, E., Herve, D., Jean-Marc, F., Bernard, H. Obstetrics and gynecology. (2006) [Pubmed]
  5. Use of sulprostone for induction of preoperative cervical dilation or uterine evacuation: a comparison among the effects of different treatment schedules. Fruzzetti, F., Melis, G.B., Strigini, F., Vettori, C., Ricci, C., Fioretti, P. Obstetrics and gynecology. (1988) [Pubmed]
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  7. Regulation of prostaglandin endoperoxide synthase-2 and IL-6 expression in mouse bone marrow-derived mast cells by exogenous but not endogenous prostanoids. Diaz, B.L., Fujishima, H., Kanaoka, Y., Urade, Y., Arm, J.P. J. Immunol. (2002) [Pubmed]
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  10. A prostaglandin E receptor coupled to a pertussis toxin-sensitive guanine nucleotide regulatory protein in rabbit cortical collecting tubule cells. Sonnenburg, W.K., Zhu, J.H., Smith, W.L. J. Biol. Chem. (1990) [Pubmed]
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  13. Third prize: Prostaglandin E(2)-3 receptor is involved in ureteral contractility in obstruction. Ankem, M.K., Jerde, T.J., Wilkinson, E.R., Nakada, S.Y. J. Endourol. (2005) [Pubmed]
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  15. Altered growth response to prostaglandin E2 and its receptor signaling in mesangial cells from stroke-prone spontaneously hypertensive rats. Suganami, T., Tanaka, I., Mukoyama, M., Kotani, M., Muro, S., Mori, K., Goto, M., Ishibashi, R., Kasahara, M., Yahata, K., Makino, H., Sugawara, A., Nakao, K. J. Hypertens. (2001) [Pubmed]
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  17. Prostaglandins inhibit secretion of histamine and pancreastatin from isolated rat stomach ECL cells. Lindström, E., Håkanson, R. Br. J. Pharmacol. (1998) [Pubmed]
  18. Prostaglandin E2 induced caspase-dependent apoptosis possibly through activation of EP2 receptors in cultured hippocampal neurons. Takadera, T., Shiraishi, Y., Ohyashiki, T. Neurochem. Int. (2004) [Pubmed]
  19. Prostaglandin E2 enhances neurotrophin-4 production via EP3 receptor in human keratinocytes. Kanda, N., Koike, S., Watanabe, S. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
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  21. Structure-activity studies of configurationally rigid arylprostaglandins. Schaaf, T.K., Johnson, M.R., Constantine, J.W., Bindra, J.S., Hess, H.J., Elger, W. J. Med. Chem. (1983) [Pubmed]
  22. Prostaglandin E2 modulates the functional responsiveness of human monocytes to chemokines. Panzer, U., Uguccioni, M. Eur. J. Immunol. (2004) [Pubmed]
  23. In vitro characterization of prostanoid EP-receptors in the non-pregnant human myometrium. Senior, J., Marshall, K., Sangha, R., Baxter, G.S., Clayton, J.K. Br. J. Pharmacol. (1991) [Pubmed]
  24. E-ring 8-isoprostanes inhibit ACh release from parasympathetic nerves innervating guinea-pig trachea through agonism of prostanoid receptors of the EP3-subtype. Clarke, D.L., Giembycz, M.A., Patel, H.J., Belvisi, M.G. Br. J. Pharmacol. (2004) [Pubmed]
  25. Electrically evoked release of [(3)H]noradrenaline from mouse cultured sympathetic neurons: release-modulating heteroreceptors. Göbel, I., Trendelenburg, A.U., Cox, S.L., Meyer, A., Starke, K. J. Neurochem. (2000) [Pubmed]
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  28. Characterization of the prostanoid receptors mediating constriction and relaxation of human isolated uterine artery. Baxter, G.S., Clayton, J.K., Coleman, R.A., Marshall, K., Sangha, R., Senior, J. Br. J. Pharmacol. (1995) [Pubmed]
  29. Developmental regulation of endothelial nitric oxide synthase in cerebral vessels of newborn pig by prostaglandin E(2). Dumont, I., Hou, X., Hardy, P., Peri, K.G., Beauchamp, M., Najarian, T., Molotchnikoff, S., Varma, D.R., Chemtob, S. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  30. Mechanisms of prostaglandin E2-induced interleukin-6 release in astrocytes: possible involvement of EP4-like receptors, p38 mitogen-activated protein kinase and protein kinase C. Fiebich, B.L., Schleicher, S., Spleiss, O., Czygan, M., Hüll, M. J. Neurochem. (2001) [Pubmed]
  31. Molecular pharmacology of aromatase and its regulation by endogenous and exogenous agents. Brueggemeier, R.W., Richards, J.A., Joomprabutra, S., Bhat, A.S., Whetstone, J.L. J. Steroid Biochem. Mol. Biol. (2001) [Pubmed]
  32. Role of prostaglandin E receptor subtypes in gastroduodenal HCO3- secretion. Takeuchi, K., Aihara, E., Hayashi, M., Sasaki, Y. Medicinal chemistry (Sh⁻ariqah, United Arab Emirates) (2005) [Pubmed]
  33. Prostaglandin E2 (PGE2) autoamplifies its production through EP1 subtype of PGE receptor in mouse osteoblastic MC3T3-E1 cells. Suda, M., Tanaka, K., Yasoda, A., Natsui, K., Sakuma, Y., Tanaka, I., Ushikubi, F., Narumiya, S., Nakao, K. Calcif. Tissue Int. (1998) [Pubmed]
  34. A randomized comparison of oxytocin, sulprostone and placebo in the management of the third stage of labour. Poeschmann, R.P., Doesburg, W.H., Eskes, T.K. British journal of obstetrics and gynaecology. (1991) [Pubmed]
  35. Analysis of 369 abortions conducted by mifepristone (RU486) associated with sulprostone in a French family planning center. Thonneau, P., Fougeyrollas, B., Spira, A. Fertil. Steril. (1994) [Pubmed]
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