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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Fetal Death

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Disease relevance of Fetal Death


High impact information on Fetal Death


Chemical compound and disease context of Fetal Death


Biological context of Fetal Death


Anatomical context of Fetal Death

  • Human parvovirus B19 is a cause of aplastic crises in patients with haemolytic anaemias, prolonged bone marrow failure in the immunosuppressed, and fetal death secondary to non-immune hydrops [16].
  • Diagnosis of fetal death in utero with amniotic fluid creatine kinase [17].
  • Mifepristone causes expulsion of the uterine contents following intrauterine fetal death and promotes dilation of the non-pregnant primigravid uterus [18].
  • Tamoxifen produced significant impairment of decidual development, which was associated with altered blood vessel transformation in the placental bed, impaired fetoplacental development and higher incidence of growth retarded fetuses and fetal death [19].
  • Abortions performed after 20 menstrual weeks were effected by instillation of intra-amniotic hyperosmolar urea or induction of fetal death by injection of digoxin and/or hyperosmolar urea into the fetus, followed by artificial rupture of membranes, induction of labor, and assisted expulsion or instrumental extraction of the fetus [20].

Gene context of Fetal Death

  • In addition, we show that although fertility of Tpst1(-/-) males and females per se is normal, Tpst1(-/-) females have significantly smaller litters because of fetal death between 8.5 and 15.5 days postcoitum [4].
  • RESULTS: Women with subsequent fetal death had both amniotic NO and VEGF lower than women with normal pregnancy (NO 3.28+/-1.20 microg/mg creatinine versus 6.02+/-1.57 microg/mg creatinine, P<0.05; VEGF 210.10+/-69.55 pg/ml versus 255.05+/-88.66 pg/ml) [21].
  • PROBLEM: Interleukin-1 (IL-1) mediated inflammatory processes have been proposed to be involved in the pathogenesis of late unexplained intrauterine fetal death (IUFD) [22].
  • This study was designed to assess if the amniotic fluid concentration of this chemokine identifies patients at risk for spontaneous abortion and/or fetal death [23].
  • It is known that TNF-alpha can cause preterm labor and intrauterine fetal death and that it is upregulated in amniotic fluid samples infected with M. hominis [24].

Analytical, diagnostic and therapeutic context of Fetal Death


  1. Second-trimester maternal serum alpha-fetoprotein levels and the risk of subsequent fetal death. Waller, D.K., Lustig, L.S., Cunningham, G.C., Golbus, M.S., Hook, E.B. N. Engl. J. Med. (1991) [Pubmed]
  2. Frequency of human parvovirus B19 infection in intrauterine fetal death. Tolfvenstam, T., Papadogiannakis, N., Norbeck, O., Petersson, K., Broliden, K. Lancet (2001) [Pubmed]
  3. A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4. Elovitz, M.A., Wang, Z., Chien, E.K., Rychlik, D.F., Phillippe, M. Am. J. Pathol. (2003) [Pubmed]
  4. Reduced body weight and increased postimplantation fetal death in tyrosylprotein sulfotransferase-1-deficient mice. Ouyang, Y.B., Crawley, J.T., Aston, C.E., Moore, K.L. J. Biol. Chem. (2002) [Pubmed]
  5. Human parvovirus B19 infection during pregnancy. Woernle, C.H., Anderson, L.J., Tattersall, P., Davison, J.M. J. Infect. Dis. (1987) [Pubmed]
  6. Bacterial lipopolysaccharide-mediated fetal death. Production of a newly recognized form of inducible cyclooxygenase (COX-2) in murine decidua in response to lipopolysaccharide. Silver, R.M., Edwin, S.S., Trautman, M.S., Simmons, D.L., Branch, D.W., Dudley, D.J., Mitchell, M.D. J. Clin. Invest. (1995) [Pubmed]
  7. Induction of labour with mifepristone after intrauterine fetal death. Cabrol, D., Bouvier D'Yvoire, M., Mermet, E., Cedard, L., Sureau, C., Baulieu, E.E. Lancet (1985) [Pubmed]
  8. Fetal death associated with severe ritodrine induced ketoacidosis. Schilthuis, M.S., Aarnoudse, J.G. Lancet (1980) [Pubmed]
  9. Cryopreservation of human fetal pancreas. Brown, J., Kemp, J.A., Hurt, S., Clark, W.R. Diabetes (1980) [Pubmed]
  10. Disseminated intravascular coagulation induced by progesterone in the pregnant rat. Prevention by estogens. Stamler, F.W. Am. J. Pathol. (1977) [Pubmed]
  11. Fetal death in mice lacking 5alpha-reductase type 1 caused by estrogen excess. Mahendroo, M.S., Cala, K.M., Landrum, D.P., Russell, D.W. Mol. Endocrinol. (1997) [Pubmed]
  12. Fertility impairment in granulocyte-macrophage colony-stimulating factor-deficient mice. Robertson, S.A., Roberts, C.T., Farr, K.L., Dunn, A.R., Seamark, R.F. Biol. Reprod. (1999) [Pubmed]
  13. Extra-amniotic saline infusion for induction of labour in antepartum fetal death: a cost effective method worthy of wider use. Mahomed, K., Jayaguru, A.S. British journal of obstetrics and gynaecology. (1997) [Pubmed]
  14. Acquired and inherited thrombophilia in women with unexplained fetal losses. Alonso, A., Soto, I., Urgellés, M.F., Corte, J.R., Rodríguez, M.J., Pinto, C.R. Am. J. Obstet. Gynecol. (2002) [Pubmed]
  15. Maternal serum diamine oxidase in fetal death and low-birth-weight infants. Gahl, W.A., Raubertas, R.F., Vale, A.M., Golubjatnikov, R. British journal of obstetrics and gynaecology. (1982) [Pubmed]
  16. Immunohistological detection of human parvovirus B19 in formalin-fixed, paraffin-embedded tissues. Morey, A.L., O'Neill, H.J., Coyle, P.V., Fleming, K.A. J. Pathol. (1992) [Pubmed]
  17. Diagnosis of fetal death in utero with amniotic fluid creatine kinase. Stempel, L.E., Lott, J.A. Am. J. Obstet. Gynecol. (1980) [Pubmed]
  18. Progesterone receptor modulators and progesterone antagonists in women's health. Spitz, I.M., Chwalisz, K. Steroids (2000) [Pubmed]
  19. The effects of the antihormones RU486 and tamoxifen on fetoplacental development and placental bed vascularisation in the rat: a model for intrauterine fetal growth retardation. Sadek, S., Bell, S.C. British journal of obstetrics and gynaecology. (1996) [Pubmed]
  20. Outpatient abortion for fetal anomaly and fetal death from 15-34 menstrual weeks' gestation: techniques and clinical management. Hern, W.M., Zen, C., Ferguson, K.A., Hart, V., Haseman, M.V. Obstetrics and gynecology. (1993) [Pubmed]
  21. Amniotic levels of nitric oxide and vascular endothelial growth factor in pregnancy with subsequent intrauterine fetal death. Tranquilli, A.L., Giannubilo, S.R., Bezzeccheri, V., Ciavattini, A., Scagnoli, C., Mazzanti, L. Eur. J. Obstet. Gynecol. Reprod. Biol. (2004) [Pubmed]
  22. Polymorphisms within the interleukin-1 gene family and unexplained late intrauterine fetal death: a multi-center study. Huber, A., Grimm, C., Jirecek, S., Zeillinger, R., Husslein, P., Hefler, L. Am. J. Reprod. Immunol. (2005) [Pubmed]
  23. Elevated monocyte chemotactic protein-1 in amniotic fluid is a risk factor for pregnancy loss. Chaiworapongsa, T., Romero, R., Tolosa, J.E., Yoshimatsu, J., Espinoza, J., Kim, Y.M., Kim, J.C., Bujold, E., Kalache, K., Edwin, S. J. Matern. Fetal. Neonatal. Med. (2002) [Pubmed]
  24. Characterization and partial purification of a macrophage-stimulating factor from Mycoplasma hominis. Peltier, M.R., Freeman, A.J., Mu, H.H., Cole, B.C. Am. J. Reprod. Immunol. (2005) [Pubmed]
  25. Regulation of prolactin secretion in the pregnant pig: effect of fetal hypophysectomy and fetal death in small litters. Kendall, J.Z., Richards, G.E., Frankowski, R.F. Biol. Reprod. (1983) [Pubmed]
  26. A comparison between vaginal prostaglandin E2 suppositories and intrauterine extra-amniotic prostaglandins in the management of fetal death in utero. Scher, J., Jeng, D.Y., Moshirpur, J., Kerenyi, T.D. Am. J. Obstet. Gynecol. (1980) [Pubmed]
  27. Gender differences in twin-twin transfusion syndrome. Nores, J., Athanassiou, A., Elkadry, E., Malone, F.D., Craigo, S.D., D'Alton, M.E. Obstetrics and gynecology. (1997) [Pubmed]
  28. Induction of labour after fetal death: a randomized controlled trial of two prostaglandin regimens. Kanhai, H.H., Keirse, M.J. British journal of obstetrics and gynaecology. (1989) [Pubmed]
  29. Vaginal prostaglandin E2 for missed abortion and intrauterine fetal death. Rutland, A., Ballard, C. Am. J. Obstet. Gynecol. (1977) [Pubmed]
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