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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Abolishment of metastasis formation by murine tumor cells transfected with "foreign" H-2K genes.

High metastatic, low immunogenic Lewis lung carcinoma clones express low levels of H-2Kb major histocompatibility complex antigens. These cells metastasize spontaneously in mice with C57BL/6 genetic background possessing the H-2Db locus. Transfection of different H-2K genes abrogates metastasis in H-2K, H-2D compatible mice and in C57BL/6 recipients. The transfected cells are potent inducers of H-2K-restricted and alloreactive cytotoxic lymphocytes that kill H-2K-positive cells and cross-react with parental nontransfected cells.[1]

References

  1. Abolishment of metastasis formation by murine tumor cells transfected with "foreign" H-2K genes. Gelber, C., Plaksin, D., Vadai, E., Feldman, M., Eisenbach, L. Cancer Res. (1989) [Pubmed]
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