- Gene localization by chromosome fractionation: globin genes are on at least two chromosomes and three estrogen-inducible genes are on three chromosomes. Hughes, S.H., Stubblefield, E., Payvar, F., Engel, J.D., Dodgson, J.B., Spector, D., Cordell, B., Schimke, R.T., Varmus, H.E. Proc. Natl. Acad. Sci. U.S.A. (1979)