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Gene Review

LOC396462  -  ovomucoid

Gallus gallus

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Disease relevance of LOC396462

  • IgE antibodies to repurified ovomucoid were significantly greater in patients with persistent egg hypersensitivity compared with patients in whom clinical tolerance developed at the time of both initial and follow-up food challenges [1].
  • Synthesis of double-stranded DNA complementary to lysozyme, ovomucoid, and ovalbumin mRNAs. Optimization for full length second strand synthesis by Escherichia coli DNA polymerase I [2].
  • Twelve recombinant phages carrying ovomucoid mRNA sequences were isolated [3].
  • On the other hand, those residues that are in contact with the enzyme in turkey ovomucoid third domain complex with Streptomyces griseus proteinase B [Read, R., Fujinaga, M., Sielecki, A. R., & James, M. N. G. (1983) Biochemistry 22, 4420-4433] are not conserved but instead are by far the most variable residues in the molecule [4].
  • BACKGROUND: Chicken ovomucoid (OM, Gal d 1) has an important role in the pathogenesis of IgE-mediated allergic reactions to hen's egg white [5].
 

High impact information on LOC396462

  • Kinetic labeling and chase experiments in oviduct tissue-suspension system indicated that the ovalbumin and ovomucoid high molecular weight RNAs which were labeled with a short-time incubation can be chased by cold nucleosides and actinomycin D into mature mRNAs [6].
  • Molecular structure and flanking nucleotide sequences of the natural chicken ovomucoid gene [7].
  • Five independent clones containing the natural chicken ovomucoid gene have been isolated from a chicken gene library [7].
  • Four globin genes alpha A, alpha D, beta, and rho or epsilon are located on at least two chromosomes, and three of the estrogen-inducible genes of the hen oviduct--ovalbumin, ovomucoid, and transferrin--are on three different chromosomes [8].
  • Nonexchangeable proton and exchangeable amide (NH) proton resonances were assigned for the hen ovomucoid glycopeptide 1, Ser-Ile-Glu-Phe-Gly-Thr-Asn Ile-Ser-Lys, with pentasaccharide Man alpha 1-3 (Man alpha 1-6)Man beta 1-4GlcNAc beta 1-4GlcNAc beta 1-NH attached to the Asn7 gamma-carboxamide [9].
 

Chemical compound and disease context of LOC396462

 

Biological context of LOC396462

  • One of these plasmids, pMu7, yielded the sequence of the 3'-untranslated region of ovomucoid mRNA [13].
  • Nearly complete methylation of the lysines of lysozyme, chicken ovomucoid, and ribonuclease was achieved with formaldehyde at pH 7.0 after 2 h at room temperature, with the retention of full activity of the protein without any destruction of tryptophan [14].
  • Effect of alkylation with different sized substituents on the conformation of ovomucoid, lysozyme and ovotransferrin [15].
  • One of these clones, CL21, contains the complete ovomucoid gene and includes more than 3 kb of DNA sequences flanking both termini of the gene [7].
  • Ovoinhibitor introns specify functional domains as in the related and linked ovomucoid gene [16].
 

Anatomical context of LOC396462

  • Immunoadsorption of specific chicken oviduct polysomes. Isolation of ovalbumin, ovomucoid, and lysozyme messenger RNA [17].
  • The largest RNAs labeled in this oviduct suspension system have a size of 7.8 kb for ovalbumin and 5.5 kb for ovomucoid, which correspond respectively to the "a" bands of steady state RNA [6].
  • METHODS: Skin prick tests were performed with fresh white and yolk from eggs of duck and goose and egg white, egg yolk, ovalbumin, and ovomucoid from hen egg [18].
  • Incubation of p erythrocytes in whole egg whites or in pigeon ovomucoid did not render them agglutinable by P-fimbriated bacteria, whereas incubation in globoside did [19].
  • All of the precursors to ovalbumin and ovomucoid mRNAs (including various splicing intermediates) and all of the precursors to ribosomal RNA were associated exclusively with the nuclear matrix fraction [20].
 

Associations of LOC396462 with chemical compounds

 

Other interactions of LOC396462

 

Analytical, diagnostic and therapeutic context of LOC396462

References

  1. Allergenicity and antigenicity of chicken egg ovomucoid (Gal d III) compared with ovalbumin (Gal d I) in children with egg allergy and in mice. Bernhisel-Broadbent, J., Dintzis, H.M., Dintzis, R.Z., Sampson, H.A. J. Allergy Clin. Immunol. (1994) [Pubmed]
  2. Synthesis of double-stranded DNA complementary to lysozyme, ovomucoid, and ovalbumin mRNAs. Optimization for full length second strand synthesis by Escherichia coli DNA polymerase I. Wickens, M.P., Buell, G.N., Schimke, R.T. J. Biol. Chem. (1978) [Pubmed]
  3. Isolation and characterization of the chicken ovomucoid gene. Lindenmaier, W., Nguyen-Huu, M.C., Lurz, R., Blin, N., Stratmann, M., Land, H., Jeep, S., Sippel, A.E., Schütz, G. Nucleic Acids Res. (1979) [Pubmed]
  4. Ovomucoid third domains from 100 avian species: isolation, sequences, and hypervariability of enzyme-inhibitor contact residues. Laskowski, M., Kato, I., Ardelt, W., Cook, J., Denton, A., Empie, M.W., Kohr, W.J., Park, S.J., Parks, K., Schatzley, B.L. Biochemistry (1987) [Pubmed]
  5. Novel B and T cell epitopes of chicken ovomucoid (Gal d 1) induce T cell secretion of IL-6, IL-13, and IFN-gamma. Holen, E., Bolann, B., Elsayed, S. Clin. Exp. Allergy (2001) [Pubmed]
  6. Processing of high molecular weight ovalbumin and ovomucoid precursor RNAs to messenger RNA. Tsai, M.J., Ting, A.C., Nordstrom, J.L., Zimmer, W., O'Malley, B.W. Cell (1980) [Pubmed]
  7. Molecular structure and flanking nucleotide sequences of the natural chicken ovomucoid gene. Lai, E.C., Stein, J.P., Catterall, J.F., Woo, S.L., Mace, M.L., Means, A.R., O'Malley, B.W. Cell (1979) [Pubmed]
  8. Gene localization by chromosome fractionation: globin genes are on at least two chromosomes and three estrogen-inducible genes are on three chromosomes. Hughes, S.H., Stubblefield, E., Payvar, F., Engel, J.D., Dodgson, J.B., Spector, D., Cordell, B., Schimke, R.T., Varmus, H.E. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  9. 1H NMR studies on an Asn-linked glycopeptide. GlcNAc-1 C2-N2 bond is rigid in H2O. Davis, J.T., Hirani, S., Bartlett, C., Reid, B.R. J. Biol. Chem. (1994) [Pubmed]
  10. Identification and fine mapping of IgG and IgE epitopes in ovomucoid. Mine, Y., Wei Zhang, J. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  11. The secondary structure of ovomucoid and its domains as studied by circular dichroism. Watanabe, K., Matsuda, T., Sato, Y. Biochim. Biophys. Acta (1981) [Pubmed]
  12. Structural and immunological characterization of recombinant ovomucoid expressed in Escherichia coli. Rupa, P., Mine, Y. Biotechnol. Lett. (2003) [Pubmed]
  13. Isolation of recombinant plasmids bearing cDNA to hen ovomucoid and lysozyme mRNAs. Buell, G.N., Wickens, M.P., Carbon, J., Schimke, R.T. J. Biol. Chem. (1979) [Pubmed]
  14. Pyridine borane as a reducing agent for proteins. Wong, W.S., Osuga, D.T., Feeney, R.E. Anal. Biochem. (1984) [Pubmed]
  15. Effect of alkylation with different sized substituents on the conformation of ovomucoid, lysozyme and ovotransferrin. Fretheim, K., Egelandsdal, B., Harbitz, O. Int. J. Pept. Protein Res. (1985) [Pubmed]
  16. Ovoinhibitor introns specify functional domains as in the related and linked ovomucoid gene. Scott, M.J., Huckaby, C.S., Kato, I., Kohr, W.J., Laskowski, M., Tsai, M.J., O'Malley, B.W. J. Biol. Chem. (1987) [Pubmed]
  17. Immunoadsorption of specific chicken oviduct polysomes. Isolation of ovalbumin, ovomucoid, and lysozyme messenger RNA. Groner, B., Hynes, N.E., Sippel, A.E., Jeep, S., Chi-Nguyen-Huu, M., Schütz, G. J. Biol. Chem. (1977) [Pubmed]
  18. Allergy to eggs from duck and goose without sensitization to hen egg proteins. Añíbarro, B., Seoane, F.J., Vila, C., Lombardero, M. J. Allergy Clin. Immunol. (2000) [Pubmed]
  19. Avian P1 antigens inhibit agglutination mediated by P fimbriae of uropathogenic Escherichia coli. Johnson, J.R., Swanson, J.L., Neill, M.A. Infect. Immun. (1992) [Pubmed]
  20. Ribonucleic acid precursors are associated with the chick oviduct nuclear matrix. Ciejek, E.M., Nordstrom, J.L., Tsai, M.J., O'Malley, B.W. Biochemistry (1982) [Pubmed]
  21. Producing a low ovomucoid egg white preparation by precipitation with aqueous ethanol. Tanabe, S., Tesaki, S., Watanabe, M. Biosci. Biotechnol. Biochem. (2000) [Pubmed]
  22. Characterization of four major allergens of hen egg-white by IEF/SDS-PAGE combined with electrophoretic transfer and IgE-immunoautoradiography. Holen, E., Elsayed, S. Int. Arch. Allergy Appl. Immunol. (1990) [Pubmed]
  23. Androgens regulate ovomucoid and ovalbumin gene expression independently of estrogen. Compere, S.J., McKnight, G.S., Palmiter, R.D. J. Biol. Chem. (1981) [Pubmed]
  24. Thermodynamics of unfolding for Kazal-type serine protease inhibitors: entropic stabilization of ovomucoid first domain by glycosylation. DeKoster, G.T., Robertson, A.D. Biochemistry (1997) [Pubmed]
  25. Interaction of egg-white glycoproteins and their oligosaccharides with the monomer and the hexamer of chicken liver lectin. A multivalent oligosaccharide-combining site exists within the carbohydrate-recognition domain. Piskarev, V.E., Navrátil, J., Karásková, H., Bezouska, K., Kocourek, J. Biochem. J. (1990) [Pubmed]
  26. Effects of serial hormone treatments on egg white protein synthesis. Further evidence of translational regulation. Seaver, S.S., Skafar, D.F. J. Steroid Biochem. (1984) [Pubmed]
  27. Inhalant allergy to egg yolk and egg white proteins. Quirce, S., Díez-Gómez, M.L., Eiras, P., Cuevas, M., Baz, G., Losada, E. Clin. Exp. Allergy (1998) [Pubmed]
 
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