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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Use of recombinant granulocyte-macrophage colony stimulating factor in the Brazil radiation accident.
8 patients with bone marrow failure after a caesium-137radiation accident were treated with recombinant human granulocyte-macrophage colony stimulating factor (rHuGM-CSF). The 7 who were evaluable had prompt increases in granulocytes and bone marrow cellularity. 2 patients died of radiation toxicity and haemorrhage and 2 of bacterial sepsis acquired before the start of rHuGM-CSF treatment. 4 patients survive, including 2 who were treated early and never became infected. This therapeutic approach to radiation-induced granulocytopenia may therefore be useful after radiation and nuclear accidents.[1]
