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Chemical Compound Review

Cesium Radioisotopes     cesium

Synonyms: Caesium-137, Cesium-137, AC1NUOLB, Cs-131, HSDB 7389, ...
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Disease relevance of cesium


High impact information on cesium

  • Mutation rate in the Mogilev families was correlated with the level of caesium-137 surface contamination, consistent with radiation induction of germline mutation [6].
  • 8 patients with bone marrow failure after a caesium-137 radiation accident were treated with recombinant human granulocyte-macrophage colony stimulating factor (rHuGM-CSF) [7].
  • Model peptides containing arginine, histidine, and lysine were irradiated using white light from a synchrotron X-ray source or a cesium-137 gamma-ray source [8].
  • We have previously shown that bladder urothelium of people living in the cesium-137 ((137)Cs)-contaminated areas of Ukraine demonstrates accumulation of stable p53 and p53 mutational inactivation, preferentially through G:C to A:T transition mutations at CpG dinucleotides, with a codon 245 hot spot [9].
  • Two groups were chosen according to soil contamination by cesium-137 at former residences, as confirmed by our findings in a 137Cs body burden study [10].

Biological context of cesium

  • Neuronal response to acetylcholine receptor activation was measured by a cation flux method at 4 degrees C in a high potassium-low sodium medium designed to stabilize membrane potential near zero, with acetylcholine as the agonist and cesium-137 as the tracer ion [11].
  • All mice received acute whole-body gamma irradiation from a Cesium-137 source and the radioprotective efficacy of the formulation was determined by measuring 30-day survival at 9 Gy, bone marrow hemopoeitic progenitor cell survival at 9 Gy and 8 Gy, and intestinal crypt cell survival at 11 Gy [12].
  • The yield of chromosome aberrations was studied in Go human peripheral blood lymphocytes following in vitro exposure to 100, 250 and 500 rad of caesium-137 gamma radiation [13].
  • This study was designed for the histopathological, cellular and biochemical characterization of a skin lesion removed surgically from a young male several months after accidental exposure to cesium-137, with an emphasis on expression of transforming growth factor beta1 (TGFB1) and tumor necrosis factor alpha (TNFA) and the occurrence of apoptosis [14].
  • Cesium-137 gamma rays were used to transform rat embryo cells (REC) which were first transfected with activated c-myc or c-Ha-ras oncogenes to produce immortal cell lines (REC:myc and REC:ras) [15].

Anatomical context of cesium


Associations of cesium with other chemical compounds

  • Extensive studies carried out in the USA have shown that though somewhat expensive, ion-exchange treatment of milk in large-scale, automated plants can eliminate 90% or more of the radionuclides of concern, i.e. strontium-90, and iodine-131, and much of caesium-137 [21].
  • Rats bearing intracerebral 9L/Ro tumors were treated with 10 daily fractions of cesium-137 gamma-rays, BCNU, or combinations of these to agents beginning on either Day 10 or Day 12 after implantation [22].
  • Mutant quantity and quality in mammalian cells (AL) exposed to cesium-137 gamma radiation: effect of caffeine [23].
  • Radiosensitivity was compared to acute Cobalt-60 radiation and low dose rate Cesium-137 under identical irradiation conditions [24].
  • Three days after 600 rads from a cesium-137 source, there was a rise in the jejunal maximal transport rate (Jdm) and the apparent Michaelis constant (Km*) but a decline in the apparent passive permeability coefficient (Pd*) for glucose [25].

Gene context of cesium

  • Nature of mutation in the human hprt gene following in vivo exposure to ionizing radiation of cesium-137 [26].
  • In Newcastle, the Manchester technique was used until 1971, when a manually afterloaded system (MAS) using caesium 137 and two source trains was introduced [27].
  • The usual measured transmission method using caesium-137 single-photon sources was used without (MTM) and with segmentation of the TX data (STM) [28].

Analytical, diagnostic and therapeutic context of cesium


  1. Combination of aziridinylbenzoquinone and cis-platinum with radiation therapy in the 9L rat brain tumor model. Kimler, B.F., Liu, C., Evans, R.G., Morantz, R.A. Int. J. Radiat. Oncol. Biol. Phys. (1993) [Pubmed]
  2. Quality control of blood irradiation: determination T cells radiosensitivity to cobalt-60 gamma rays. Góes, E.G., Borges, J.C., Covas, D.T., Orellana, M.D., Palma, P.V., Morais, F.R., Pelá, C.A. Transfusion (2006) [Pubmed]
  3. Correlations of dose and time-dose-fractionation factors (TDF) with treatment results and side effects in cancer of the uterine cervix. Yudelev, M., Kuten, A., Tatcher, M., Rubinov, R., Karmeli, R., Cohen, Y., Robinson, E. Gynecol. Oncol. (1986) [Pubmed]
  4. Possible distinct molecular carcinogenic pathways for bladder cancer in Ukraine, before and after the Chernobyl disaster. Morimura, K., Romanenko, A., Min, W., Salim, E.I., Kinoshita, A., Wanibuchi, H., Vozianov, A., Fukushima, S. Oncol. Rep. (2004) [Pubmed]
  5. A new technique of brachytherapy for malignant gliomas with caesium-137: a new method utilizing a remote afterloading system. Ashpole, R.D., Snyman, H., Bullimore, J.A., Appleby, H.J., Cummins, B.H., Coakham, H.B. Clinical oncology (Royal College of Radiologists (Great Britain)) (1990) [Pubmed]
  6. Human minisatellite mutation rate after the Chernobyl accident. Dubrova, Y.E., Nesterov, V.N., Krouchinsky, N.G., Ostapenko, V.A., Neumann, R., Neil, D.L., Jeffreys, A.J. Nature (1996) [Pubmed]
  7. Use of recombinant granulocyte-macrophage colony stimulating factor in the Brazil radiation accident. Butturini, A., De Souza, P.C., Gale, R.P., Cordiero, J.M., Lopes, D.M., Neto, C., Cunha, C.B., De Souza, C.E., Ho, W.G., Tabak, D.G. Lancet (1988) [Pubmed]
  8. Radiolytic modification of basic amino acid residues in peptides: probes for examining protein-protein interactions. Xu, G., Takamoto, K., Chance, M.R. Anal. Chem. (2003) [Pubmed]
  9. Increased oxidative stress with gene alteration in urinary bladder urothelium after the Chernobyl accident. Romanenko, A., Morimura, K., Wanibuchi, H., Salim, E.I., Kinoshita, A., Kaneko, M., Vozianov, A., Fukushima, S. Int. J. Cancer (2000) [Pubmed]
  10. Health effects in a casual sample of immigrants to Israel from areas contaminated by the Chernobyl explosion. Kordysh, E.A., Goldsmith, J.R., Quastel, M.R., Poljak, S., Merkin, L., Cohen, R., Gorodischer, R. Environ. Health Perspect. (1995) [Pubmed]
  11. Concanavalin A inhibits nicotinic acetylcholine receptor function in cultured chick ciliary ganglion neurons. Messing, A., Bizzini, B., Gonatas, N.K. Brain Res. (1984) [Pubmed]
  12. Radioprotection in mice following oral delivery of amifostine nanoparticles. Pamujula, S., Kishore, V., Rider, B., Fermin, C.D., Graves, R.A., Agrawal, K.C., Mandal, T.K. Int. J. Radiat. Biol. (2005) [Pubmed]
  13. The effect of changes in dose rate on the yield of chromosome aberrations in human lymphocytes exposed to gamma radiation. Purrott, R.J., Reeder, E. Mutat. Res. (1976) [Pubmed]
  14. Histopathological and cellular studies of a case of cutaneous radiation syndrome after accidental chronic exposure to a cesium source. Vozenin-Brotons, M.C., Gault, N., Sivan, V., Tricaud, Y., Dubray, B., Clough, K., Cosset, J.M., Lefaix, J.L., Martin, M. Radiat. Res. (1999) [Pubmed]
  15. Rat embryo cells immortalized with transfected oncogenes are transformed by gamma irradiation. Endlich, B., Salavati, R., Sullivan, T., Ling, C.C. Radiat. Res. (1992) [Pubmed]
  16. Applicator for use of cesium-137 miniaturized tube sources in the treatment of uterine cervix cancer. Kumar, P.P., Good, R.R., McCaul, G.F. Int. J. Radiat. Oncol. Biol. Phys. (1990) [Pubmed]
  17. Analysis of blood lymphocyte subsets in children living around Chernobyl exposed long-term to low doses of cesium-137 and various doses of iodine-131. Vykhovanets, E.V., Chernyshov, V.P., Slukvin, I.I., Antipkin, Y.G., Vasyuk, A., Colos, V. Radiat. Res. (2000) [Pubmed]
  18. Stage II endometrial carcinoma treated with external-beam radiotherapy, intracavitary application of cesium, and surgery. Podczaski, E.S., Kaminski, P., Manetta, A., Louk, D., Andrews, C., Larson, J., DeGeest, K., Mortel, R. Gynecol. Oncol. (1989) [Pubmed]
  19. Effect of external abdominal irradiation on the dimensions and characteristics of the barriers to passive transport in the rat intestine. Thomson, A.B., Cheeseman, C.I., Walker, K. Lipids (1984) [Pubmed]
  20. Array comparative genomic hybridisation analysis of gamma-irradiated human thyrocytes. Finn, S.P., Smyth, P., O'regan, E., Cahill, S., Flavin, R., O'leary, J., Sheils, O. Virchows Arch. (2004) [Pubmed]
  21. Decontamination of radioactive milk--a review. Patel, A.A., Prasad, S.R. Int. J. Radiat. Biol. (1993) [Pubmed]
  22. Efficacy of continuous treatment with radiation in a rat brain-tumor model. Wheeler, K.T., Kaufman, K. J. Neurosurg. (1981) [Pubmed]
  23. Mutant quantity and quality in mammalian cells (AL) exposed to cesium-137 gamma radiation: effect of caffeine. McGuinness, S.M., Shibuya, M.L., Ueno, A.M., Vannais, D.B., Waldren, C.A. Radiat. Res. (1995) [Pubmed]
  24. RBE of spleen CFU-S to low dose rate Cf-252 neutron or photon radiation. Maruyama, Y., Feola, J.M., Hwang, H.N., Williams, A., Beach, J.L. Radiation and environmental biophysics. (1983) [Pubmed]
  25. Effect of abdominal irradiation on the kinetic parameters of intestinal uptake of glucose, galactose, leucine, and gly-leucine in the rat. Thomson, A.B., Cheeseman, C.I., Walker, K. J. Lab. Clin. Med. (1983) [Pubmed]
  26. Nature of mutation in the human hprt gene following in vivo exposure to ionizing radiation of cesium-137. da Cruz, A.D., Glickman, B.W. Environ. Mol. Mutagen. (1997) [Pubmed]
  27. Gynaecological treatments using the Selectron remote afterloading system. Dean, E.M., Lambert, G.D., Dawes, P.J. The British journal of radiology. (1988) [Pubmed]
  28. Attenuation compensation in cerebral 3D PET: effect of the attenuation map on absolute and relative quantitation. Zaidi, H., Montandon, M.L., Slosman, D.O. Eur. J. Nucl. Med. Mol. Imaging (2004) [Pubmed]
  29. Neutron brachytherapy is better than conventional radiotherapy in advanced cervical cancer. Maruyama, Y., Kryscio, R., van Nagell, J.R., Yoneda, J., Donaldson, E., Hanson, M., Beach, J.L., Feola, J.M., Martin, A., Parker, C. Lancet (1985) [Pubmed]
  30. Medium dose rate endobronchial radiotherapy with caesium-137. George, P.J., Hadley, J.M., Mantell, B.S., Rudd, R.M. Thorax (1992) [Pubmed]
  31. Increase of regional total cancer incidence in north Sweden due to the Chernobyl accident? Tondel, M., Hjalmarsson, P., Hardell, L., Carlsson, G., Axelson, O. Journal of epidemiology and community health. (2004) [Pubmed]
  32. Iodine-129 and caesium-137 in Chernobyl contaminated soil and their chemical fractionation. Hou, X.L., Fogh, C.L., Kucera, J., Andersson, K.G., Dahlgaard, H., Nielsen, S.P. Sci. Total Environ. (2003) [Pubmed]
  33. Immobilization of cesium-137 in cement-waste composites by addition of mineral zeolites. Matsuzuru, H., Ito, A. Health physics. (1978) [Pubmed]
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