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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Quantitative scanning of osteogenic sarcoma with nitrogen-13-labeled L-glutamate.

N-13 L-glutamate was used to image an osteogenic sarcoma in a 9-year-old patient. Serial quantitative measurements of the amount of N-13 taken up by the primary tumor showed a decrease of 40% after 10 wk of chemotherapy. Blood-clearance data obtained from normal subjects indicate that more than 90% of the N-13 activity had left the blood before scanning of the tumor was begun. It appears that the N-13 label concentrated in the soft-tissue portion of this osteogenic sarcoma, whereas Tc-99m diphosphonate uptake was greatest in the regions where calcification was occurring.[1]


  1. Quantitative scanning of osteogenic sarcoma with nitrogen-13-labeled L-glutamate. Gelbard, A.S., Benua, R.S., Laughlin, J.S., Rosen, G., Reiman, R.E., McDonald, J.M. J. Nucl. Med. (1979) [Pubmed]
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