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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Phenotypic and genotypic characterization of penicillinase-producing strains of Neisseria gonorrhoeae.

Thirty penicillinase-producing Neisseria gonorrhoeae (PPNG) strains, 26 representing 9 serovars of the protein IB and 4 representing 2 serovars of the protein IA serogroup, had 10 different patterns when investigated by the restriction enzyme (RE) technique with Hind III enzyme. One RE pattern dominated, representing 11 strains with 6 different serovars of both the protein IA and IB serogroup. Identical serovars and RE patterns were found among 7 patients (3, 2 and 2, respectively) with positive epidemiology. The majority of the strains (24/30) were resistant to, or showed decreased sensitivity to, doxycycline with minimum inhibitory concentrations between 1 and 8 mg/l, consistent with the Far East origin. All the 30 PPNG strains showed by agarose gel electrophoresis to harbour a 2.8 Mdalton, a 4.4 Mdalton, as well as a 24.5 Mdalton plasmid, whereas the two non-PPNG strains had only the 2.8 Mdalton plasmid.[1]


  1. Phenotypic and genotypic characterization of penicillinase-producing strains of Neisseria gonorrhoeae. Falk, E.S., Danielsson, D., Bjorvatn, B., Melby, K., Sørensen, B., Kristiansen, B.E., Lund, S., Sandström, E. Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology. (1985) [Pubmed]
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