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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Glucocorticoid modulates the sensitivity of the GABAA receptor on primary afferent neurons of bullfrogs.

With intracellular and voltage-clamp recording techniques, we have demonstrated that the glucocorticoids, prednisolone and hydrocortisone at a concentration of 5 microM to 1 mM, reversibly depressed gamma-aminobutyric acid (GABA)-induced responses on primary afferent neurons of bullfrogs. An analysis with dose-response curves revealed that the glucocorticoids decreased the sensitivity of the GABAA receptor in a non-competitive manner. We suggest that glucocorticoids act as an antagonist of the GABAA receptor on primary afferent neurons, probably by reducing the number of functional GABAA receptor ionic channel complexes.[1]

References

  1. Glucocorticoid modulates the sensitivity of the GABAA receptor on primary afferent neurons of bullfrogs. Ariyoshi, M., Akasu, T. Brain Res. (1986) [Pubmed]
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