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MeSH Review

Rana catesbeiana

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Disease relevance of Rana catesbeiana

  • Ionic currents activated by extracellular adenosine 5'-triphosphate (ATP) were studied in voltage-clamped dorsal root ganglion neurons from rats and bullfrogs [1].
  • In adult bullfrogs exposed to chronic hypoxia, the morphology of the gas exchange organs does not change (Burggren & Mwalukomo, 1983), but instead profound adjustments occur in the blood, favouring O2 transport under these conditions [2].
  • The bullfrogs are able to increase whole body cutaneous gas flux during prolonged apnea but were not able to respond to changes in local O2 content [3].
  • These results suggest that factors associated with intensive agricultural practices may affect the body weight and retinoid stores in male bullfrogs living in these agroecosystems [4].

High impact information on Rana catesbeiana

  • We have studied the desensitization to substance P (SP) by whole-cell recordings from dissociated sympathetic neurons from bullfrogs [5].
  • During metamorphic stages and in juvenile bullfrogs, the expression of TH becomes transiently bimodal: many neurons are intensely positive; the remainder are faintly positive [6].
  • Double-label experiments in late-stage tadpoles and juvenile bullfrogs revealed that the intensely TH-positive neurons are negative for NPY [6].
  • Substance P suppresses GABAA receptor function via protein kinase C in primary sensory neurones of bullfrogs [7].
  • Together, these observations indicate that dopamine mimics the effect of light on cone and RPE retinomotor movements in both fish and bullfrogs [8].

Chemical compound and disease context of Rana catesbeiana


Biological context of Rana catesbeiana


Anatomical context of Rana catesbeiana


Associations of Rana catesbeiana with chemical compounds


Gene context of Rana catesbeiana

  • Using the cDNA as a probe, the content of GH mRNA in the pituitary of larval and adult bullfrogs was measured [25].
  • Epinephrine (4 x 10(-8) M), the amphibian sympathetic postganglionic neurotransmitter, stimulated leukotriene synthesis by brains from warm-acclimated bullfrogs, and the effect was blocked with the 5-lipoxygenase inhibitor MK-886 (5 x 10(-5) M) [26].
  • In bullfrogs, the bullfrog GH (about 2 microgram/injection) stimulated growth and appetite in intact frogs, and improved survival in hypophysectomized frogs [27].
  • Previously, the doubling of hind limb dorsal root ganglion (DRG) neurons in postmetamorphic bullfrogs (Rana catesbeiana) was found to occur in the absence of neuron proliferation (St. Wecker and Farel [1994] J. Comp. Neurol. 342:430-438) [28].
  • On the other hand, prolactin significantly inhibited calling in female bullfrogs, but had no affect in males [29].

Analytical, diagnostic and therapeutic context of Rana catesbeiana


  1. ATP-activated channels in rat and bullfrog sensory neurons: current-voltage relation and single-channel behavior. Bean, B.P., Williams, C.A., Ceelen, P.W. J. Neurosci. (1990) [Pubmed]
  2. Respiration during chronic hypoxia and hyperoxia in larval and adult bullfrogs (Rana catesbeiana). II. Changes in respiratory properties of whole blood. Pinder, A., Burggren, W. J. Exp. Biol. (1983) [Pubmed]
  3. Regional variation and control of cutaneous gas exchange in bullfrogs. Talbot, C.R. Respiration physiology. (1992) [Pubmed]
  4. Hepatic retinoids of bullfrogs in relation to agricultural pesticides. Boily, M.H., Bérubé, V.E., Spear, P.A., DeBlois, C., Dassylva, N. Environ. Toxicol. Chem. (2005) [Pubmed]
  5. Desensitization of the inhibition of the M-current in sympathetic neurons: effects of ATP analogs, polyanions, and multiple agonist applications. Simmons, M.A., Becker, J.B., Mather, R.J. Neuron (1990) [Pubmed]
  6. Expression of neuropeptide-Y-like immunoreactivity begins after adrenergic differentiation and ganglionic synaptogenesis in developing bullfrog sympathetic neurons. Stofer, W.D., Horn, J.P. J. Neurosci. (1990) [Pubmed]
  7. Substance P suppresses GABAA receptor function via protein kinase C in primary sensory neurones of bullfrogs. Yamada, K., Akasu, T. J. Physiol. (Lond.) (1996) [Pubmed]
  8. Dopamine induces light-adaptive retinomotor movements in bullfrog cones via D2 receptors and in retinal pigment epithelium via D1 receptors. Dearry, A., Edelman, J.L., Miller, S., Burnside, B. J. Neurochem. (1990) [Pubmed]
  9. Respiration during chronic hypoxia and hyperoxia in larval and adult bullfrogs (Rana catesbeiana). I. Morphological responses of lungs, skin and gills. Burggren, W., Mwalukoma, A. J. Exp. Biol. (1983) [Pubmed]
  10. Compensation of progressive hypercapnia in the toad (Bufo marinus) and the bullfrog (Rana catesbeiana). Toews, D.P., Stiffler, D.F. J. Exp. Biol. (1990) [Pubmed]
  11. Cardiovascular responses to catecholamines at 12 degrees C in the American bullfrog (Rana catesbeiana). Herman, C.A., Robleto, D.O., Mata, P.L., Heller, R.S. J. Exp. Zool. (1986) [Pubmed]
  12. Plasma retinoid profile in bullfrogs, Rana catesbeiana, in relation to agricultural intensity of sub-watersheds in the Yamaska River drainage basin, Québec, Canada. Bérubé, V.E., Boily, M.H., DeBlois, C., Dassylva, N., Spear, P.A. Aquat. Toxicol. (2005) [Pubmed]
  13. Immunocytochemistry of luteinizing hormone-releasing hormone and sexual maturation of the frog brain: comparisons of juvenile and adult bullfrogs (Rana catesbeiana). Crim, J.W. Gen. Comp. Endocrinol. (1985) [Pubmed]
  14. Direct cardiac stimulation by arginine vasotocin in bullfrogs (Rana catesbeiana). Sham, J.S., Sawyer, W.H., Pang, P.K. Am. J. Physiol. (1989) [Pubmed]
  15. Propranolol blocks recurrent synaptic activation in paravertebral sympathetic ganglia of bullfrogs. Nishimura, T., Akasu, T. Neurosci. Lett. (1988) [Pubmed]
  16. Glucocorticoid modulates the sensitivity of the GABAA receptor on primary afferent neurons of bullfrogs. Ariyoshi, M., Akasu, T. Brain Res. (1986) [Pubmed]
  17. Excitatory and inhibitory effects of tricaine (MS-222) on fictive breathing in isolated bullfrog brain stem. Hedrick, M.S., Winmill, R.E. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2003) [Pubmed]
  18. Action of 5-hydroxytryptamine on isolated spinal cord of bullfrogs. Shirasawa, Y., Koketsu, K. Jpn. J. Pharmacol. (1977) [Pubmed]
  19. Circulation of cerebrospinal fluid in the bullfrog, Rana catesbiana. Tornheim, P.A., Foltz, F.M. Anat. Rec. (1979) [Pubmed]
  20. Initial observations of rabbit retinal pigment epithelium-choroid-sclera preparations. Frambach, D.A., Valentine, J.L., Weiter, J.J. Invest. Ophthalmol. Vis. Sci. (1988) [Pubmed]
  21. Vitamin A transport in plasma of the non-mammalian vertebrates: isolation and partial characterization of piscine retinol-binding protein. Shidoji, Y., Muto, Y. J. Lipid Res. (1977) [Pubmed]
  22. Induced ovulation and changes in pituitary responsiveness to continuous infusion of gonadotropin-releasing hormone during the ovarian cycle in the bullfrog, Rana catesbeiana. McCreery, B.R., Licht, P. Biol. Reprod. (1983) [Pubmed]
  23. Studies on the comparative pharmacology and selective toxicity of tricaine methanesulfonate: metabolism as a basis of the selective toxicity in poikilotherms. Wayson, K.A., Downes, H., Lynn, R.K., Gerber, N. J. Pharmacol. Exp. Ther. (1976) [Pubmed]
  24. Exposure to 4-tert-octylphenol accelerates sexual differentiation and disrupts expression of steroidogenic factor 1 in developing bullfrogs. Mayer, L.P., Dyer, C.A., Propper, C.R. Environ. Health Perspect. (2003) [Pubmed]
  25. Cloning of a bullfrog growth hormone cDNA: expression of growth hormone mRNA in larval and adult bullfrog pituitaries. Takahashi, N., Kikuyama, S., Gen, K., Maruyama, O., Kato, Y. J. Mol. Endocrinol. (1992) [Pubmed]
  26. Eicosanoid synthesis by warm- and cold-acclimated American bullfrog (Rana catesbeiana) brain. Martinez, J.M., Chapunoff, D., Romero, M.A., Herman, C.A. J. Exp. Zool. (1994) [Pubmed]
  27. Biological activity of bullfrog growth hormone in the rat and the bullfrog (Rana catesbeiana). Farmer, S.W., Light, P., Papkoff, H. Endocrinology (1977) [Pubmed]
  28. Neuron addition during growth of the postmetamorphic bullfrog: sensory neuron and axon number. Meeker, M.L., Farel, P.B. J. Comp. Neurol. (1997) [Pubmed]
  29. Sexual differences in hormonal control of release calls in bullfrogs. Boyd, S.K. Hormones and behavior. (1992) [Pubmed]
  30. Immunocytochemistry of luteinizing hormone-releasing hormone during spontaneous and thyroxine-induced metamorphosis of bullfrogs. Whalen, R., Crim, J.W. J. Exp. Zool. (1985) [Pubmed]
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