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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effects of cefotaxime and cefodizime on human granulocyte functions in vitro.

In vitro, cefotaxime and cefodizime enhanced significantly the bactericidal activity of human neutrophils against Staphylococcus aureus P 209 A, but not phagocytosis. The increase was about 150% for cefotaxime and 400% for cefodizime at concentrations as low as 1 mg/l. Furthermore, by two different techniques (NBT and cytochrome C reduction tests) cefotaxime but not cefodizime significantly enhanced superoxide anion production by zymosan-stimulated neutrophils. Other neutrophil functions (chemotaxis and myeloperoxidase-mediated iodination of proteins) were not significantly altered by either antibiotic, even at concentrations as high as 1000 mg/l.[1]


  1. Effects of cefotaxime and cefodizime on human granulocyte functions in vitro. Labro, M.T., Babin-Chevaye, C., Hakim, J. J. Antimicrob. Chemother. (1986) [Pubmed]
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