Tumorigenicity test of 1,3- and 1,8-dinitropyrene in BALB/c mice.
1,3-Dinitropyrene (DNP) and 1,8-DNP ( CAS: 42397-65-9) are very potent mutagens and induce a frameshift-type mutation in the Salmonella test system. Each compound was tested for tumorigenicity in BALB/c mice by sc inoculation of 0.05 mg of the compound once a week for 20 weeks. Tumors developed at the site of injection of 1,8-DNP in 6 of 15 mice up to 60 weeks after the first injection. The incidence of tumors was statistically significant at a P-value of less than .05 but not of less than .01. Therefore, the carcinogenicity of 1,8-DNP in BALB/c mice was concluded to be weaker than that of benzo[a]pyrene [(BP) CAS: 50-32-8], which induced a 100% tumor incidence when it was injected at the same dose as that of 1,8-DNP. No tumors occurred at the injection site in mice given 1,3-DNP. Most of the tumors induced by 1,8-DNP and BP showed histologic features characteristic of malignant fibrous histiocytoma.[1]References
- Tumorigenicity test of 1,3- and 1,8-dinitropyrene in BALB/c mice. Otofuji, T., Horikawa, K., Maeda, T., Sano, N., Izumi, K., Otsuka, H., Tokiwa, H. J. Natl. Cancer Inst. (1987) [Pubmed]
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