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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The effect of CS-514 on serum lipids and apolipoproteins in hypercholesterolemic subjects.

CS-514 is a metabolic product of compactin and has a potent cholesterol-lowering effect in vitro and in animal studies by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase. The efficacy and adverse effects of the agent were studied in 41 hypercholesterolemic subjects by administering daily doses of 5, 20, or 40 mg for four weeks under double-blind conditions. Mean total serum cholesterol level was reduced by 11.1% in the 5-mg group, 18.8% in the 20-mg group, and 25.3% in the 40-mg group. Marked reduction of total serum cholesterol level was also observed in heterozygous familial hypercholesterolemics. Mean low-density lipoprotein cholesterol level and apolipoprotein B concentration decreased by 38.5% and 28.8%, respectively, in the 40-mg group, while high-density lipoprotein cholesterol level increased by 11.8%. No serious clinical and laboratory abnormalities were observed. Plasma cortisol and testosterone levels were not significantly affected. These results suggest that CS-514 will be a useful agent in the treatment of nonfamilial and heterozygous familial hypercholesterolemia.[1]


  1. The effect of CS-514 on serum lipids and apolipoproteins in hypercholesterolemic subjects. Nakaya, N., Homma, Y., Tamachi, H., Shigematsu, H., Hata, Y., Goto, Y. JAMA (1987) [Pubmed]
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