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SC-39026, a specific human neutrophil elastase inhibitor.

SC-39026, (+/-) 2-chloro-4-(1-hydroxyoctadecyl)benzoic acid, inhibits human neutrophil elastase with an IC50 of 0.5 microM (KI of 1.5 microM). Its inhibition of elastase is reversible and noncompetitive at low concentrations (0.5-1.25 microM). Inhibition is "mixed" at higher inhibitor concentrations. SC-39026 is inactive against hog pancreatic elastase, bovine alpha-chymotrypsin and Pseudomonas aeruginosa elastase, but does inhibit human neutrophil cathepsin G with an IC50 of approximately 2.5 microM. Neutrophil elastases isolated from rat, hamster, rabbit and hog are also inhibited by SC-39026.[1]

References

  1. SC-39026, a specific human neutrophil elastase inhibitor. Nakao, A., Partis, R.A., Jung, G.P., Mueller, R.A. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
 
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