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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Interrelationships between energy and fat metabolism and hypophagia in rats treated with perfluorodecanoic acid.

Energy metabolism and body composition were investigated in perfluorodecanoic acid (PFDA)-treated rats (single i.p. dose of 20, 40 or 80 mg/kg) and their respective pair-fed counterparts 7 days after dosing. Cumulative feed intake and body weight were decreased in a dose-dependent manner. However, PFDA-treated rats either gained less weight or lost more weight (dependent on the dose administered) than their pair-fed, vehicle-treated counterparts, even though feed intake in these two treatment groups was similar. Energy expenditure, determined indirectly by quantifying oxygen consumption and carbon dioxide production, decreased in a dose-dependent fashion, yet it was similar in PFDA-treated rats and their pair-fed counterparts at a given dose. Body composition analysis indicated a dose-dependent decrease in carcass water and protein content in both PFDA-treated rats and pair-fed partners, while total amount of ash remained unchanged in all treatment groups. These alterations in body composition are compatible with a negative energy balance. Even though PFDA-treated rats had a lower body weight than their pair-fed counterparts at each dose level, they were found to have a greater carcass fat content. Thus, at maintenance (i.e., zero change of body weight) PFDA-treated rats require a higher caloric intake associated with a greater body fat content than vehicle-treated animals.[1]


  1. Interrelationships between energy and fat metabolism and hypophagia in rats treated with perfluorodecanoic acid. Van Rafelghem, M.J., Noren, C.W., Menahan, L.A., Peterson, R.E. Toxicol. Lett. (1988) [Pubmed]
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