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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Treatment of experimental myasthenia with autologous idiotypes linked to muramyl dipeptide.

In order to develop a new treatment of experimental autoimmune myasthenia gravis (EAMG), rabbits were injected with purified acetylcholine receptor (AChR) from Torpedo californica. Polyclonal affinity-purified anti-AChR antibodies (idiotypes, Ids) were coupled covalently to muramyl dipeptide and injected back into the same (i.e. autologous) rabbits from which the Ids were obtained. Treated animals developed anti-Ids that bound to the F(ab')2 fragments of the Ids as demonstrated by ELISA and that also blocked binding of Ids to AChR in a radioimmunoassay. Treated animals showed a protective effect compared to control animals when challenged with a second injection of AChR. Anti-AChR titres in surviving animals achieved a steady-state equilibrium. No apparent toxicity from the treatment was noted.[1]

References

  1. Treatment of experimental myasthenia with autologous idiotypes linked to muramyl dipeptide. Valderrama, R., Eggers, A.E., Moomjy, M., Kao, P.N., Michl, J. Clin. Exp. Immunol. (1988) [Pubmed]
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