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Chemical Compound Review

Muramyl Dipeptide     (4R)-4-[[(2S)-2-[[(2R)-2- [(2R,5S)-3...

Synonyms: LS-71900, BRN 4220745, AC1L24LJ, C19H32N4O11, 53678-77-6, ...
 
 
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Disease relevance of Muramyl Dipeptide

 

Psychiatry related information on Muramyl Dipeptide

 

High impact information on Muramyl Dipeptide

 

Chemical compound and disease context of Muramyl Dipeptide

 

Biological context of Muramyl Dipeptide

 

Anatomical context of Muramyl Dipeptide

 

Associations of Muramyl Dipeptide with other chemical compounds

 

Gene context of Muramyl Dipeptide

 

Analytical, diagnostic and therapeutic context of Muramyl Dipeptide

References

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  3. Isolation of tumoricidal macrophages from lung melanoma metastases of mice treated systemically with liposomes containing a lipophilic derivative of muramyl dipeptide. Key, M.E., Talmadge, J.E., Fogler, W.E., Bucana, C., Fidler, I.J. J. Natl. Cancer Inst. (1982) [Pubmed]
  4. Eradication of spontaneous metastases and activation of alveolar macrophages by intravenous injection of liposomes containing muramyl dipeptide. Fidler, I.J., Sone, S., Fogler, W.E., Barnes, Z.L. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  5. Enhancement of the neonate's nonspecific immunity to Klebsiella infection by muramyl dipeptide, a synthetic immunoadjuvant. Parant, M., Parant, F., Chedid, L. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
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  9. Sex differences in the effects of muramyl dipeptide and lipopolysaccharide on locomotor activity and the development of behavioral tolerance in rats. Engeland, C.G., Kavaliers, M., Ossenkopp, K.P. Pharmacol. Biochem. Behav. (2003) [Pubmed]
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  13. Analysis of human blood monocyte activation at the level of gene expression. Expression of alpha interferon genes during activation of human monocytes by poly IC/LC and muramyl dipeptide. Stevenson, H.C., Dekaban, G.A., Miller, P.J., Benyajati, C., Pearson, M.L. J. Exp. Med. (1985) [Pubmed]
  14. Stimulating effect of MDP and its adjuvant-active analogues on guinea pig fibroblasts for the production of thymocyte-activating factor. Iribe, H., Koga, T., Kotani, S., Kusumoto, S., Shiba, T. J. Exp. Med. (1983) [Pubmed]
  15. Streptococcal cell walls and synovial cell activation. Stimulation of synovial fibroblast plasminogen activator activity by monocytes treated with group A streptococcal cell wall sonicates and muramyl dipeptide. Hamilton, J.A., Zabriskie, J.B., Lachman, L.B., Chen, Y.S. J. Exp. Med. (1982) [Pubmed]
  16. Involvement of macrophages in the eradication of established metastases following intravenous injection of liposomes containing macrophage activators. Fidler, I.J., Barnes, Z., Fogler, W.E., Kirsh, R., Bugelski, P., Poste, G. Cancer Res. (1982) [Pubmed]
  17. Activation of alveolar macrophage tumoricidal activity and eradication of experimental metastases by freeze-dried liposomes containing a new lipophilic muramyl dipeptide derivative. Phillips, N.C., Moras, M.L., Chedid, L., Lefrancier, P., Bernard, J.M. Cancer Res. (1985) [Pubmed]
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  19. Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition. Tanabe, T., Chamaillard, M., Ogura, Y., Zhu, L., Qiu, S., Masumoto, J., Ghosh, P., Moran, A., Predergast, M.M., Tromp, G., Williams, C.J., Inohara, N., Núñez, G. EMBO J. (2004) [Pubmed]
  20. Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations. Li, J., Moran, T., Swanson, E., Julian, C., Harris, J., Bonen, D.K., Hedl, M., Nicolae, D.L., Abraham, C., Cho, J.H. Hum. Mol. Genet. (2004) [Pubmed]
  21. Stimulation of the in vivo dinitrophenyl antibody response to the DNP conjugate of L-glutamic acid60-L-alanine30-L-Tyrosine10 (GAT) polymer by a synthetic adjuvant, muramyl dipeptide (MDP): target cells for adjuvant activity and isotypic pattern of MDP-stimulated response. Lowy, I., Theze, J., Chedid, L. J. Immunol. (1980) [Pubmed]
  22. Activation of macrophages for enhanced release of superoxide anion and greater killing of Candida albicans by injection of muramyl dipeptide. Cummings, N.P., Pabst, M.J., Johnston, R.B. J. Exp. Med. (1980) [Pubmed]
  23. Increased production of superoxide anion by macrophages exposed in vitro to muramyl dipeptide or lipopolysaccharide. Pabst, M.J., Johnston, R.B. J. Exp. Med. (1980) [Pubmed]
  24. Modulation of monocyte functions by muramyl tripeptide phosphatidylethanolamine in a phase II study in patients with metastatic melanoma. Liebes, L., Walsh, C.M., Chachoua, A., Oratz, R., Richards, D., Hochster, H., Peace, D., Marino, D., Alba, S., Le Sher, D. J. Natl. Cancer Inst. (1992) [Pubmed]
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  26. Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation. Oswald, I.P., Wynn, T.A., Sher, A., James, S.L. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  27. Effects of liposome structure and lipid composition on the activation of the tumoricidal properties of macrophages by liposomes containing muramyl dipeptide. Schroit, A.J., Fidler, I.J. Cancer Res. (1982) [Pubmed]
  28. Enhancement of carrier-specific helper T cell function by the synthetic adjuvant, N-acetyl muramyl-L-alanyl-D-isoglutamine (MDP). Sugimoto, M., Germain, R.N., Chedid, L., Benacerraf, B. J. Immunol. (1978) [Pubmed]
  29. Inhibition of human IL 2 production by MDP and derivatives. Leclerc, C., Morin, A., Deriaud, E., Chedid, L. J. Immunol. (1984) [Pubmed]
  30. Role of nod2 in the response of macrophages to toll-like receptor agonists. Pauleau, A.L., Murray, P.J. Mol. Cell. Biol. (2003) [Pubmed]
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  32. A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling. McDonald, C., Chen, F.F., Ollendorff, V., Ogura, Y., Marchetto, S., Lécine, P., Borg, J.P., Nuñez, G. J. Biol. Chem. (2005) [Pubmed]
  33. Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives: monoacylated MDP confers TLR2/TLR4 activation. Uehori, J., Fukase, K., Akazawa, T., Uematsu, S., Akira, S., Funami, K., Shingai, M., Matsumoto, M., Azuma, I., Toyoshima, K., Kusumoto, S., Seya, T. J. Immunol. (2005) [Pubmed]
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  35. Systemic activation of tumoricidal properties in mouse macrophages and inhibition of melanoma metastases by the oral administration of MTP-PE, a lipophilic muramyl dipeptide. Fidler, I.J., Fogler, W.E., Brownbill, A.F., Schumann, G. J. Immunol. (1987) [Pubmed]
  36. Efficient induction of collagen arthritis by the use of a synthetic muramyl dipeptide. Koga, T., Sakamoto, S., Onoue, K., Kotani, S., Sumiyoshi, A. Arthritis Rheum. (1980) [Pubmed]
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