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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Supranuclear disturbances of ocular motility in Lytico-Bodig.

We found abnormal supranuclear ocular or lid motility in all of 37 patients with Lytico-Bodig (amyotrophic lateral sclerosis/parkinsonism-dementia complex). Twenty-one patients had pursuit paresis, 18 abnormal vestibulo-ocular reflex (VOR) cancellation, 15 abnormal convergence, 13 abnormal optokinetic nystagmus (OKN), 12 conjugate gaze limitation, nine nystagmus, nine saccadic paresis, and six abnormal fixation. Lid abnormalities included glabellar hyperreflexia in 21, involuntary levator inhibition in three, and blepharospasm in two. Earlier reports have indicated infrequent ocular disturbances in Lytico-Bodig, but we now find supranuclear eye and lid deficits are universal and sometimes very prominent.[1]


  1. Supranuclear disturbances of ocular motility in Lytico-Bodig. Lepore, F.E., Steele, J.C., Cox, T.A., Tillson, G., Calne, D.B., Duvoisin, R.C., Lavine, L., McDarby, J.V. Neurology (1988) [Pubmed]
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