Disease relevance of Reflex, Vestibulo-Ocular

• Internuclear ophthalmoplegia. II. Pursuit, optokinetic nystagmus, and vestibulo-ocular reflex [1].
• Vestibulo-ocular reflex in migraine patients: the effect of sodium valproate [2].
• Changes in the three-dimensional angular vestibulo-ocular reflex following intratympanic gentamicin for Ménière's disease [3].
• The effect of betahistine on the vestibulo-ocular reflex (VOR) was assessed in 12 patients suffering from paroxysmal vertigo [4].
• In an attempt to investigate some aspects of the high pressure nervous syndrome, the vestibulo-ocular reflex (VOR) gain was measured in two professional divers undergoing a simulated dive at 62 ATA [5].

Psychiatry related information on Reflex, Vestibulo-Ocular

• These results suggest that tonic levels of otolithic and somatosensory activity in combination with canalicular, cervical, and motor activity regulate the velocity storage mechanism of the horizontal vestibuloocular reflex (Cohen et al. 1977; Raphan et al. 1979) and sensations of after-rotation [6].

High impact information on Reflex, Vestibulo-Ocular

• Reductions in CaMKII activity are necessary and sufficient to induce firing rate potentiation and may contribute to motor learning in the vestibulo-ocular reflex [7].
• These data strongly support the hypothesis that activation of PKC in the Purkinje cell is necessary for cerebellar LTD induction, and that cerebellar LTD is required for a particular form of motor learning, adaptation of the vestibulo-ocular reflex [8].
• Whereas the absolute gain, phase, and latency values of the vestibulo-ocular reflex and optokinetic reflex of the L7-PKCI mice were normal, their ability to adapt their vestibulo-ocular reflex gain during visuo-vestibular training was absent [8].
• Expression of a protein kinase C inhibitor in Purkinje cells blocks cerebellar LTD and adaptation of the vestibulo-ocular reflex [8].
• On the other hand, local injections of NO donors or 8-Br-cGMP produced alterations of eye velocity during both spontaneous eye movements and vestibulo-ocular reflex (VOR), as well as changes in eye position generation exclusively during spontaneous eye movements [9].

Anatomical context of Reflex, Vestibulo-Ocular

• The horizontal vestibuloocular reflex (VOR) of Purkinje cell degeneration (pcd/pcd) mutant mice, which lack a functional cerebellar cortex, was compared in darkness to that of wild-type animals during constant velocity yaw rotations about an earth-horizontal axis and during sinusoidal yaw rotations about an earth-vertical axis [10].
• We studied the role of the nucleus of the optic tract (NOT) in adapting the gain of the angular vestibulo-ocular reflex (aVOR) in rhesus and cynomolgus monkeys using lesions and temporary inactivation with muscimol [11].
• The effects of nociceptin (orphanin FQ) on medial vestibular nucleus (MVN) neurons in vitro, and on vestibulo-ocular reflex (VOR) function in vivo, were investigated in order to determine the role of 'opioid-like orphan' (ORL1) receptors in modulating vestibular reflex function in the rat [12].
• The effects of ethyl alcohol and heavy water on the long-time constant (T1) of the vestibulo-ocular reflex, an index of the dynamics of the cupula-endolymph system of the semicircular canal, were investigated in rabbits [13].
• This vertical strabismus has been attributed to asymmetric disruption of vestibuloocular reflex (VOR) projections from otolithic receptors of the utricle to ocular motoneurons, but asymmetry of the utriculo-ocular counter-roll reflex has not been detected [14].

Associations of Reflex, Vestibulo-Ocular with chemical compounds

• Following treatment with thiamine, both patients' vestibular responses improved but remained abnormal, with a short vestibulo-ocular reflex time constant and increased low-frequency rotational phase lead [15].
• The effects of 25 mg cinnarizine on the vestibulo-ocular reflex were investigated in 13 subjects [16].
• Taken together, these findings suggest that nicotine induces an imbalance in the vestibulo-ocular reflex [17].
• Each aspect of nystagmus that is dependent on the velocity-storage mechanism in the vestibulo-ocular reflex (v.o.r.) was altered by the drug: (a) Baclofen reduced the dominant time constant of the v.o.r. in a dose-dependent manner up to 5 mg/kg, the highest dosage used [18].
• This article reports an investigation into the vestibuloocular reflex (VOR) recorded in rats during acute nontoxic treatment with phenytoin (PHT) [19].

Gene context of Reflex, Vestibulo-Ocular

• Horizontal vestibuloocular reflex (VOR) head velocity estimation in Purkinje cell degeneration (pcd/pcd) mutant mice [10].
• To evaluate the cerebellar functions of Fyn-kinase, we examined the dynamic characteristics of the horizontal optokinetic response (HOKR) and vestibulo-ocular reflex (HVOR) and its adaptability in Fyn-kinase-deficient mice [20].
• Impaired vestibulo-ocular reflex gain occurred with SCA3 only [21].
• First, the abnormal stimulus being applied to the vestibular system during BPPV episodes is estimated by an analysis of the vestibulo-ocular reflex (VOR) response of clinical BPPV patients [22].
• The gain in vestibulo-ocular reflex was significantly impaired in SCA3 and SCA1 [23].

Analytical, diagnostic and therapeutic context of Reflex, Vestibulo-Ocular

• These results show that electrical stimulation and reversible lesions in areas previously shown to alter the gain of the vestibulo-ocular reflex (VOR) also alter CF input to the flocculus, suggesting that the gain changes were caused by changes in CS rate [24].
• Electronystagmography showed significant decreases in the gain of the vestibuloocular reflex in participants receiving phenytoin [25].

References