Disease relevance of Nystagmus, Optokinetic

• RESULTS: On neurologic examination, the PSGCs exhibited significantly more definite or possible abnormalities than NGCs for overall oculomotor function, saccade velocity, optokinetic nystagmus, chorea of the extremities, and dystonia of the extremities (P<.05) [1].
• 4. Oculogyric crises, paralysis of downward gaze, prolonged reaction time of saccade and poor optokinetic nystagmus were seen in a patient with juvenile Parkinsonism, whose neuropathological examination revealed the most striking changes in the substantia nigra, central grey and midline portion, and ventral and caudal to the central grey [2].
• We recorded the VEP to a horizontally oscillating vertical sinusoidal grating in 20 patients with infantile strabismus (esotropia, asymmetry of the monocular optokinetic nystagmus, latent nystagmus) and in 10 normal controls [3].

High impact information on Nystagmus, Optokinetic

• Using the 14C-deoxyglucose technique, we compared local rates of cerebral glucose utilization in cats viewing a moving optokinetic nystagmus (OKN) drum (experimental group) with those in cats viewing a stationary OKN drum (control group) [4].
• Early repair of strabismus in infant monkeys has been shown to restore normal development of motion responsiveness for pursuit and optokinetic eye movements (optokinetic nystagmus [OKN]) [5].
• CONCLUSIONS: Psychomotor speed, optokinetic nystagmus, and rapid alternating movements demonstrated significant decline early in the pathological process of HD [6].
• Impairment of pupillary responses and optokinetic nystagmus in the mGluR6-deficient mouse [7].
• The GABAa agonist muscimol, on the other hand, blocked optokinetic nystagmus (OKN) [8].

Biological context of Nystagmus, Optokinetic

• Since specific benzodiazepine (Bz) binding sites have been found in the vision and oculomotor control areas of the central nervous system (CNS), the fast phases of optokinetic nystagmus (OKN) should be affected by Bz administration [9].
• Inverted optokinetic nystagmus was elicited in albino rats by restricting the optokinetic stimulation to the anterior visual field of both eyes [10].
• The effects of intravenously administered diazepam (0.6 mg/kg) on vestibulo-ocular reflex (VOR), optokinetic nystagmus (OKN), optovestibular reflex (OVR) and their after-nystagmus were examined in rabbits [11].

Anatomical context of Nystagmus, Optokinetic

• A series of neuro-otological tests revealed prolonged acoustically evoked brain stem response (ABR) latency, disturbed standing reflex, inhibited optokinetic nystagmus (OKN) and ataxic eye tracking test (ETT) [12].

Associations of Nystagmus, Optokinetic with chemical compounds

• Analysis of vertebrate eye movements following intravitreal drug injections. I. Blockade of retinal ON-cells by 2-amino-4-phosphonobutyrate eliminates optokinetic nystagmus [13].
• Such pathways confirm previous physiological studies in rat and, in particular, clarify the contrasting effects of electrolytic lesions of NRTP in rat which completely abolishes optokinetic nystagmus (OKN) (Cazin et al., 1980a) vs kainic acid lesions which produce only minor effects on OKN slow velocity (Hess et al., 1988) [14].
• Diazepam-induced changes of optokinetic nystagmus fast phase [9].
• In a previous study, bilateral injection of the aselective cholinergic agonist carbachol in the flocculus shortened the duration of buildup of optokinetic nystagmus (OKN) and the duration of OKAN, suggesting floccular involvement in velocity storage (Tan et al. 1992) [15].
• We found that, despite the animal's dissociated state and despite specific influences of ketamine on the oculomotor system, optokinetic nystagmus (OKN) could be reliably elicited with large, moving visual patterns [16].

Gene context of Nystagmus, Optokinetic

• Retinal projections to the pretectal and terminal accessory optic nuclei were studied in normal wild-type mice and mutant mice with abnormal optokinetic nystagmus (OKN, Mangini, Vanable, Williams, and Pinto: J. Comp. Neurol. 241:191-209, '85) [17].
• Optokinetic nystagmus in strabismus: are asymmetries related to binocularity [18]?
• Our data suggest that somatostatin is involved in visual and visuomotor reflex pathways and in the horizontal optokinetic nystagmus reflex pathway [19].
• Optokinetic nystagmus in albino rats depends on stimulus pattern [10].
• The reported lesions can help to explain the truncal and postural instability as well as the impaired optokinetic nystagmus, vestibulo-ocular reaction, and horizontal gaze-holding present in SCA3 cases [20].

Analytical, diagnostic and therapeutic context of Nystagmus, Optokinetic

• The effects of lidocaine in doses of 2.0--6.0 mg/kg with intravenous injection on optokinetic nystagmus were observed in 21 rabbits [21].
• Combined analysis of horizontal and vertical optokinetic nystagmus reactions by means of ENG and brain mapping [22].

References