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MeSH Review

Nystagmus, Optokinetic

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Disease relevance of Nystagmus, Optokinetic


High impact information on Nystagmus, Optokinetic


Biological context of Nystagmus, Optokinetic


Anatomical context of Nystagmus, Optokinetic

  • A series of neuro-otological tests revealed prolonged acoustically evoked brain stem response (ABR) latency, disturbed standing reflex, inhibited optokinetic nystagmus (OKN) and ataxic eye tracking test (ETT) [12].

Associations of Nystagmus, Optokinetic with chemical compounds

  • Analysis of vertebrate eye movements following intravitreal drug injections. I. Blockade of retinal ON-cells by 2-amino-4-phosphonobutyrate eliminates optokinetic nystagmus [13].
  • Such pathways confirm previous physiological studies in rat and, in particular, clarify the contrasting effects of electrolytic lesions of NRTP in rat which completely abolishes optokinetic nystagmus (OKN) (Cazin et al., 1980a) vs kainic acid lesions which produce only minor effects on OKN slow velocity (Hess et al., 1988) [14].
  • Diazepam-induced changes of optokinetic nystagmus fast phase [9].
  • In a previous study, bilateral injection of the aselective cholinergic agonist carbachol in the flocculus shortened the duration of buildup of optokinetic nystagmus (OKN) and the duration of OKAN, suggesting floccular involvement in velocity storage (Tan et al. 1992) [15].
  • We found that, despite the animal's dissociated state and despite specific influences of ketamine on the oculomotor system, optokinetic nystagmus (OKN) could be reliably elicited with large, moving visual patterns [16].

Gene context of Nystagmus, Optokinetic


Analytical, diagnostic and therapeutic context of Nystagmus, Optokinetic


  1. Confirmation of subtle motor changes among presymptomatic carriers of the Huntington disease gene. Kirkwood, S.C., Siemers, E., Bond, C., Conneally, P.M., Christian, J.C., Foroud, T. Arch. Neurol. (2000) [Pubmed]
  2. Oculomotor characteristics of parkinsonism in comparison with those of cerebellar ataxia. Shimizu, N., Mizuno, M. J. Neural Transm. Suppl. (1983) [Pubmed]
  3. Asymmetry of motion VEP in infantile strabismus and in central vestibular nystagmus. Kommerell, G., Ullrich, D., Gilles, U., Bach, M. Documenta ophthalmologica. Advances in ophthalmology. (1995) [Pubmed]
  4. Cortical areas involved in horizontal OKN in cats: metabolic activity. Herdman, S.J., Tusa, R.J., Smith, C.B. J. Neurosci. (1989) [Pubmed]
  5. Early versus delayed repair of infantile strabismus in macaque monkeys: II. Effects on motion visually evoked responses. Tychsen, L., Wong, A.M., Foeller, P., Bradley, D. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  6. Longitudinal cognitive and motor changes among presymptomatic Huntington disease gene carriers. Kirkwood, S.C., Siemers, E., Stout, J.C., Hodes, M.E., Conneally, P.M., Christian, J.C., Foroud, T. Arch. Neurol. (1999) [Pubmed]
  7. Impairment of pupillary responses and optokinetic nystagmus in the mGluR6-deficient mouse. Iwakabe, H., Katsuura, G., Ishibashi, C., Nakanishi, S. Neuropharmacology (1997) [Pubmed]
  8. Analysis of vertebrate eye movements following intravitreal drug injections. III. Spontaneous nystagmus is modulated by the GABAa receptor. Ariel, M. J. Neurophysiol. (1989) [Pubmed]
  9. Diazepam-induced changes of optokinetic nystagmus fast phase. Wang, C., Tian, J., Liang, P., Sun, F. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (2005) [Pubmed]
  10. Optokinetic nystagmus in albino rats depends on stimulus pattern. Sirkin, D.W., Hess, B.J., Precht, W. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1985) [Pubmed]
  11. Differential effects of diazepam upon vestibulo- and visual-oculomotor responses in the rabbit. Matsunaga, T., Shiraishi, T., Kubo, T. Acta oto-laryngologica. Supplementum. (1983) [Pubmed]
  12. Aqueductal stenosis--results of vestibular function tests. Suzuki, M., Harada, Y., Ishida, M., Wada, H., Ohta, M., Sakoda, K., Uozumi, T. The Journal of laryngology and otology. (1985) [Pubmed]
  13. Analysis of vertebrate eye movements following intravitreal drug injections. I. Blockade of retinal ON-cells by 2-amino-4-phosphonobutyrate eliminates optokinetic nystagmus. Knapp, A.G., Ariel, M., Robinson, F.R. J. Neurophysiol. (1988) [Pubmed]
  14. Projections of the nucleus of the optic tract to the nucleus reticularis tegmenti pontis and prepositus hypoglossi nucleus in the pigmented rat as demonstrated by anterograde and retrograde transport methods. Korp, B.G., Blanks, R.H., Torigoe, Y. Vis. Neurosci. (1989) [Pubmed]
  15. Shortening of vestibular nystagmus in response to velocity steps by microinjection of carbachol in the rabbit's cerebellar flocculus. Tan, H.S., Collewijn, H., Van der Steen, J. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1993) [Pubmed]
  16. Visual processing in the ketamine-anesthetized monkey. Optokinetic and blood oxygenation level-dependent responses. Leopold, D.A., Plettenberg, H.K., Logothetis, N.K. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (2002) [Pubmed]
  17. Retinopretectal and accessory optic projections of normal mice and the OKN-defective mutant mice beige, beige-J, and pearl. Pak, M.W., Giolli, R.A., Pinto, L.H., Mangini, N.J., Gregory, K.M., Vanable, J.W. J. Comp. Neurol. (1987) [Pubmed]
  18. Optokinetic nystagmus in strabismus: are asymmetries related to binocularity? Valmaggia, C., Proudlock, F., Gottlob, I. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  19. Somatostatin (SRIF)-like immunoreactivity in subcortical and cortical visual centers of the rat. Laemle, L.K., Feldman, S.C. J. Comp. Neurol. (1985) [Pubmed]
  20. Degeneration of the central vestibular system in spinocerebellar ataxia type 3 (SCA3) patients and its possible clinical significance. Rüb, U., Brunt, E.R., de Vos, R.A., Del Turco, D., Del Tredici, K., Gierga, K., Schultz, C., Ghebremedhin, E., Bürk, K., Auburger, G., Braak, H. Neuropathol. Appl. Neurobiol. (2004) [Pubmed]
  21. The influence of intravenous injection of lidocaine on optokinetic nystagmus in rabbits. Tokunaga, O. Archives of oto-rhino-laryngology. (1977) [Pubmed]
  22. Combined analysis of horizontal and vertical optokinetic nystagmus reactions by means of ENG and brain mapping. Claussen, C.F., Schneider, D., Fraass, U., Hahn, A. Acta oto-laryngologica. Supplementum. (1991) [Pubmed]
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