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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A human monoclonal anti-DNA antibody derived from a patient with polymyositis having the common lupus 16/6 idiotype.

A human IgM monoclonal antibody (Pol-1, SA-1) was generated by the human hybridoma technique from the peripheral blood lymphocytes (PBL) of a patient with active polymyositis. The antibody was found to bind to ssDNA, dsDNA, poly(I) and poly(G) and to carry the common lupus anti-DNA antibody idiotype (16/6 Id). Another human IgM monoclonal antibody (Pol-2, SA-2) produced by similar methods from the PBL of the same patient while in remission lacked the ligand-binding capacities of Pol-1 SA-1 and did not have the 16/6 Id. Analyses of 19 sera samples from patients with polymyositis showed no antinuclear antibodies, excluding a 40% prevalence of the 16/6 Id. The serum of the patient whose lymphocytes were employed to generate the hybridoma was negative for anti-DNA activity as well as for the 16/6 Id. This study suggests that the hybridoma technique may enable expression of dormant idiotypic affinities which do not normally appear in sera.[1]

References

  1. A human monoclonal anti-DNA antibody derived from a patient with polymyositis having the common lupus 16/6 idiotype. Shoenfeld, Y., Livne, A., Blank, M., Argov, S., Krup, M., Fleishmakher, E., Sukenik, S., Teplizki, H. Immunol. Lett. (1988) [Pubmed]
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