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Gene Review

STAG2  -  stromal antigen 2

Homo sapiens

Synonyms: Cohesin subunit SA-2, SA-2, SA2, SCC3 homolog 2, SCC3B, ...
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Disease relevance of STAG2


Psychiatry related information on STAG2

  • Another human IgM monoclonal antibody (Pol-2, SA-2) produced by similar methods from the PBL of the same patient while in remission lacked the ligand-binding capacities of Pol-1 SA-1 and did not have the 16/6 Id [2].

High impact information on STAG2


Biological context of STAG2


Anatomical context of STAG2

  • Human CD4-positive T cells were cultured with phytohemagglutinin in the presence or absence of 0.1 microM recombinant cystatin SA1 or SA2 [9].
  • Recent work has implicated the System N transporter SN1 in the efflux of glutamine from astrocytes and the very closely related System A transporters SA1 and SA2 in glutamine uptake by neurons [10].

Associations of STAG2 with chemical compounds

  • A continuing study of the ingredients of Puerariae Radix, the roots of Pueraria lobata (WILLD.) OHWI, which is one of the most important crude drugs, has resulted in the first isolation of four new oleanene-type triterpene glycosides, named kudzusaponins SA1, SA2, SA3 and C1 (1-4) [11].
  • The half-life for decomposition (tau(1/2)) of the unsymmetrical initiators at 37 degrees C in methanol covered a range of 121 hours for SA-1, 77 hours for SA-2, and approximately 25 hours for the series C-16, C-12, and C-8 [12].
  • Sixty-three ASA 1 orA SA 2 children aged one year and above were randomly assigned to receive diclofenac (Group A) or paracetamol (Group B) [13].

Other interactions of STAG2

  • Eighteen amino acids determined among 20 N-terminal residues of cystatin SA2 are identical with the sequence encoded by CST2 [14].

Analytical, diagnostic and therapeutic context of STAG2

  • The difference in the electrophoretic positions of the two proteins, SA1 and SA2, in a basic gel and in an isoelectric focusing gel agreed with the expected mobilities of the proteins with the SA2 variant at a more anodal position [15].
  • A nuclear factor kappaB-dependent signaling pathway mediated by SA-2 ligation of TLR7 was responsible for these effects [7].


  1. Evidence of a transcriptional co-activator function of cohesin STAG/SA/Scc3. Lara-Pezzi, E., Pezzi, N., Prieto, I., Barthelemy, I., Carreiro, C., Martínez, A., Maldonado-Rodríguez, A., López-Cabrera, M., Barbero, J.L. J. Biol. Chem. (2004) [Pubmed]
  2. A human monoclonal anti-DNA antibody derived from a patient with polymyositis having the common lupus 16/6 idiotype. Shoenfeld, Y., Livne, A., Blank, M., Argov, S., Krup, M., Fleishmakher, E., Sukenik, S., Teplizki, H. Immunol. Lett. (1988) [Pubmed]
  3. Characterization of vertebrate cohesin complexes and their regulation in prophase. Sumara, I., Vorlaufer, E., Gieffers, C., Peters, B.H., Peters, J.M. J. Cell Biol. (2000) [Pubmed]
  4. STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis. Prieto, I., Pezzi, N., Buesa, J.M., Kremer, L., Barthelemy, I., Carreiro, C., Roncal, F., Martinez, A., Gomez, L., Fernandez, R., Martinez-A, C., Barbero, J.L. EMBO Rep. (2002) [Pubmed]
  5. Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2. Hauf, S., Roitinger, E., Koch, B., Dittrich, C.M., Mechtler, K., Peters, J.M. PLoS Biol. (2005) [Pubmed]
  6. Production and characterization of two variants of human cystatin SA encoded by two alleles at the CST2 locus of the type 2 cystatin gene family. Saitoh, E., Minaguchi, K., Ishibashi, O. Arch. Biochem. Biophys. (1998) [Pubmed]
  7. Redirection of allergen-specific TH2 responses by a modified adenine through Toll-like receptor 7 interaction and IL-12/IFN release. Filì, L., Ferri, S., Guarna, F., Sampognaro, S., Manuelli, C., Liotta, F., Cosmi, L., Matucci, A., Vultaggio, A., Annunziato, F., Maggi, E., Guarna, A., Romagnani, S., Parronchi, P. J. Allergy Clin. Immunol. (2006) [Pubmed]
  8. Increased frequency of the heterozygous switch region of IgA2 in Japanese patients with IgA nephropathy. Miyazaki, M., Kashem, A., Ihara, S., Yano, N., Endoh, M., Nomoto, Y., Sakai, H. Intern. Med. (1992) [Pubmed]
  9. Cystatin SA, a cysteine proteinase inhibitor, induces interferon-gamma expression in CD4-positive T cells. Kato, T., Ito, T., Imatani, T., Minaguchi, K., Saitoh, E., Okuda, K. Biol. Chem. (2004) [Pubmed]
  10. Glutamine uptake by neurons: interaction of protons with system a transporters. Chaudhry, F.A., Schmitz, D., Reimer, R.J., Larsson, P., Gray, A.T., Nicoll, R., Kavanaugh, M., Edwards, R.H. J. Neurosci. (2002) [Pubmed]
  11. Oleanene-type triterpene glycosides from Puerariae Radix. II. Isolation of saponins and the application of tandem mass spectrometry to their structure determination. Arao, T., Kinjo, J., Nohara, T., Isobe, R. Chem. Pharm. Bull. (1995) [Pubmed]
  12. Design of unsymmetrical azo initiators to increase radical generation efficiency in low-density lipoproteins. Culbertson, S.M., Porter, N.A. Free Radic. Res. (2000) [Pubmed]
  13. Diclofenac or paracetamol for analgesia in paediatric myringotomy outpatients. Tay, C.L., Tan, S. Anaesthesia and intensive care. (2002) [Pubmed]
  14. Genetic polymorphisms of the CST2 locus coding for cystatin SA. Shintani, M., Minaguchi, K., Isemura, S., Saitoh, E., Sanada, K., Semba, T. Hum. Genet. (1994) [Pubmed]
  15. Sequence variations of the CST2 gene related to the polymorphism of salivary cystatin SA. Haga, T., Minaguchi, K. J. Dent. Res. (1999) [Pubmed]
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