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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Immune basis for cimetidine-induced pancytopenia.

We report a case of a female patient with chronic myelogenous leukemia who presented, 8 yr after initial diagnosis, with pancytopenia, encephalopathy, and myalgia. The tentative diagnosis was accelerated phase of chronic myelogenous leukemia. However, because the patient had been treated with cimetidine for 7 months we first omitted this drug. When cimetidine was stopped, bone marrow recovered, and myalgia and encephalopathy subsided. Immunological studies showed stimulation of the patient's lymphocyte blastogenesis by cimetidine and a marked increase in the proportion of cytotoxic/suppressor T lymphocytes after incubation of peripheral blood lymphocytes with cimetidine for 6 days. These findings indicate a role for cell-mediated immunity in the pathogenesis of cimetidine-induced pancytopenia in this patient.[1]


  1. Immune basis for cimetidine-induced pancytopenia. Nagler, A., Rozenbaum, H., Enat, R., Tatarsky, I., Katz, R., Pollack, S. Am. J. Gastroenterol. (1987) [Pubmed]
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