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MeSH Review

Lymphocyte Activation

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Disease relevance of Lymphocyte Activation


Psychiatry related information on Lymphocyte Activation


High impact information on Lymphocyte Activation

  • No correlation could be demonstrated between the plasma salicylic acid level and the degree of suppression of blastogenesis [7].
  • The anergic V beta 6 T-helper cells express IL-2 receptors and undergo limited blastogenesis in vitro upon stimulation, but do not produce IL-2, in marked contrast to V beta 6 cells from naive mice [8].
  • AAG has the ability to inhibit certain lymphocyte re-activities including blastogenesis in response to concanavalin A, phytohaemagglutinin and allogeneic cells, and these inhibitory effects are enhanced in association with desialisation [9].
  • While these treatments did not render macrophages stimulatory for an MLR in purified CD4+ cells, blastogenesis of CD4+ cells was observed when the MLR involved bulk T cells [10].
  • Anti-LFA-1 disassembles newly formed DC-T cell aggregates, whereas anti-CD4 inhibits blastogenesis without disrupting the cluster [11].

Chemical compound and disease context of Lymphocyte Activation


Biological context of Lymphocyte Activation


Anatomical context of Lymphocyte Activation


Associations of Lymphocyte Activation with chemical compounds

  • Inclusion in serum-free or serum-containing medium of the optimal concentration (5 x 10(-5) M) of either 2-ME or alpha TG resulted in highly significant uptake and incorporation of tritiated thymidine ([3H]TdR) into DNA and in morphological blast transformation [26].
  • Furthermore, purified IL-2 failed to correct PPD-induced blastogenesis in patients [27].
  • Sonicates of spleen cells which had been activated with optimal concentrations of 2-ME for 24 h and then washed extensively, stimulated the uptake of tritiated thymidine and morphological blast transformation of fresh, unstimulated cells [28].
  • Evidence is presented that the majority of mouse spleen cells binding tritium-labeled POL undergoes blastogenesis after antigen capping, antigen shedding, and receptor reformation [29].
  • An extracellular product of group A streptococci which induces lymphocyte blastogenesis has been purified to homogeneity by DEAE-cellulose and CM-cellulose chromatography [30].

Gene context of Lymphocyte Activation


Analytical, diagnostic and therapeutic context of Lymphocyte Activation

  • Sensitized cells were also examined for their ability to respond to purified protein derivative (PPD) by blastogenesis, migration inhibitory factor release (MIP), and lymphotoxin (LT) production, both before and after treatment with HTLA and complement [36].
  • The LPCA assay correlated closely with the blast transformation and MIF tests in which cells were used from more strongly sensitized donors who reacted in skin tests with lower doses of tuberculin (1 or 10 TU) [37].
  • T/B lymphocyte ratios, lymphocyte blastogenesis (LB) with PHA and with cancer antigen preparations were carried out from two to four weeks after cancer surgery, and immediately after eight weeks of immunostimulation with a tumor-specific vaccine [38].
  • Allograft survival appeared to be directly related to the immunosuppressive activity of patient sera on phytohemagglutinin-induced blastogenesis of normal lymphocytes in vitro [39].
  • The administration of steroid caused significant immunosuppression in most animals as measured by inhibition of splenocyte blastogenesis induced with phytohemagglutinin [40].


  1. HLA-DR histocompatibility leukocyte antigens permit cultured human melanoma cells from early but not advanced disease to stimulate autologous lymphocytes. Guerry, D., Alexander, M.A., Herlyn, M.F., Zehngebot, L.M., Mitchell, K.F., Zmijewski, C.M., Lusk, E.J. J. Clin. Invest. (1984) [Pubmed]
  2. Mitogen-induced blastogenesis and receptor mobility inhibition by breast cancer serum with elevated orosomucoid (alpha 1-acid glycoprotein) levels. Cheresh, D.A., Distasio, J.A., Vogel, C.L., Lopez, D.M. J. Natl. Cancer Inst. (1982) [Pubmed]
  3. Human lymphocyte blastogenesis responses to mouse mammary tumor virus. Wiseman, C.L., Bowen, J.M., Davis, J.W., Hersh, E.M., Brown, B.W., Blumenschein, G.R. J. Natl. Cancer Inst. (1980) [Pubmed]
  4. Studies on the mechanism of T cell inhibition by the Pseudomonas aeruginosa phenazine pigment pyocyanine. Nutman, J., Berger, M., Chase, P.A., Dearborn, D.G., Miller, K.M., Waller, R.L., Sorensen, R.U. J. Immunol. (1987) [Pubmed]
  5. HTLV-III large envelope protein (gp120) suppresses PHA-induced lymphocyte blastogenesis. Mann, D.L., Lasane, F., Popovic, M., Arthur, L.O., Robey, W.G., Blattner, W.A., Newman, M.J. J. Immunol. (1987) [Pubmed]
  6. Immunosuppressant pharmacodynamics on peripheral-blood mononuclear cells from patients with ulcerative colitis. Hirano, T., Akashi, T., Kido, T., Oka, K., Shiratori, T., Miyaoka, M. Int. Immunopharmacol. (2002) [Pubmed]
  7. Suppression of lymphocyte transformation after aspirin ingestion. Crout, J.E., Hepburn, B., Ritts, R.E. N. Engl. J. Med. (1975) [Pubmed]
  8. Clonal anergy induced in mature V beta 6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells. Rammensee, H.G., Kroschewski, R., Frangoulis, B. Nature (1989) [Pubmed]
  9. Inhibition of platelet aggregation by native and desialised alpha-1 acid glycoprotein. Costello, M., Fiedel, B.A., Gewurz, H. Nature (1979) [Pubmed]
  10. Neuraminidase-treated macrophages stimulate allogenic CD8+ T cells in the presence of exogenous interleukin 2. Hirayama, Y., Inaba, K., Inaba, M., Kato, T., Kitaura, M., Hosokawa, T., Ikehara, S., Muramatsu, S. J. Exp. Med. (1988) [Pubmed]
  11. Monoclonal antibodies to LFA-1 and to CD4 inhibit the mixed leukocyte reaction after the antigen-dependent clustering of dendritic cells and T lymphocytes. Inaba, K., Steinman, R.M. J. Exp. Med. (1987) [Pubmed]
  12. Listeria cell wall fraction: a B cell mitogen. Cohen, J.J., Rodriguez, G.E., Kind, P.D., Campbell, P.A. J. Immunol. (1975) [Pubmed]
  13. Immune responses and immunoregulation in relation to human schistosomiasis in Egypt. II. Cimetidine reversal of histamine-mediated suppression of antigen-induced blastogenesis. Barsoum, I.S., Dahawi, H.S., Gamil, F.M., Habib, M., El Alamy, M.A., Colley, D.G. J. Immunol. (1984) [Pubmed]
  14. Suppressed in vitro blastogenic responsiveness of rat spleen cells after continuous infusion of endotoxin by an implanted osmotic pump. Spitzer, J.A., Friedman, H., Newton, C., Widen, R., Pross, S., Klein, T.W. Proc. Soc. Exp. Biol. Med. (1987) [Pubmed]
  15. Inhibition of lymphocyte response by prostaglandin-producing suppressor cells in patients with melanoma. Murray, J.L., Kollmorgen, G.M. J. Clin. Immunol. (1983) [Pubmed]
  16. Effects of vitamin E and selenium deficiencies on rat immune function. Eskew, M.L., Scholz, R.W., Reddy, C.C., Todhunter, D.A., Zarkower, A. Immunology (1985) [Pubmed]
  17. Human immunodeficiency virus infection of helper T cell clones. Early proliferative defects despite intact antigen-specific recognition and interleukin 4 secretion. Laurence, J., Friedman, S.M., Chartash, E.K., Crow, M.K., Posnett, D.N. J. Clin. Invest. (1989) [Pubmed]
  18. Visualization of antigen-specific T cell activation and cytokine expression in vivo. Rogers, W.O., Weaver, C.T., Kraus, L.A., Li, J., Li, L., Bucy, R.P. J. Immunol. (1997) [Pubmed]
  19. Differential expression of cell activation markers after stimulation of resting human B lymphocytes. Kehrl, J.H., Muraguchi, A., Fauci, A.S. J. Immunol. (1984) [Pubmed]
  20. Effects of arachidonic acid and other unsaturated fatty acids on mitogenesis in human lymphocytes. Kelly, J.P., Parker, C.W. J. Immunol. (1979) [Pubmed]
  21. Migration and activation of antigen-specific CD8+ T cells upon in vivo stimulation with allogeneic tumor. Kedl, R.M., Mescher, M.F. J. Immunol. (1997) [Pubmed]
  22. Immune responses to a soluble schistosomal egg antigen preparation during chronic primary infection with Schistosoma mansoni. Colley, D.G. J. Immunol. (1975) [Pubmed]
  23. Production of an eosinophil chemotactic lymphokine by a monocyte-derived factor from patients with hypereosinophilia. Muramoto, K., Sakata, K., Miyauchi, Y., Hirashima, M., Hayashi, H. J. Leukoc. Biol. (1988) [Pubmed]
  24. Effect of estradiol and progesterone on lymphocyte and neutrophil functions in steers. Roth, J.A., Kaeberle, M.L., Hsu, W.H. Infect. Immun. (1982) [Pubmed]
  25. Suppressor alveolar macrophages in mice bearing metastatic Lewis lung carcinoma tumors. Young, M.R., Endicott, R.A., Duffie, G.P., Wepsic, H.T. J. Leukoc. Biol. (1987) [Pubmed]
  26. Nonspecific activation of murine lymphocytes. I. Proliferation and polyclonal activation induced by 2-mercaptoethanol and alpha-thioglycerol. Goodman, M.G., Weigle, W.O. J. Exp. Med. (1977) [Pubmed]
  27. Defective interleukin 2 production and responsiveness in human pulmonary tuberculosis. Toossi, Z., Kleinhenz, M.E., Ellner, J.J. J. Exp. Med. (1986) [Pubmed]
  28. Nonspecific activation of murine lymphocytes. VI. Mediation of synergistic interaction between T and B lymphocytes by a cell-associated, reciprocally acting lymphocyte proliferation helper. Goodman, M.G., Weigle, W.O. J. Exp. Med. (1979) [Pubmed]
  29. Antigen recognition. IV. Discrimination by antigen-binding immunocompetent B cells between immunity and tolerance is determined by adherent cells. Diener, E., Kraft, N., Lee, K.C., Shiozawa, C. J. Exp. Med. (1976) [Pubmed]
  30. Purification and properties of an extracellular blastogen produced by group A streptococci. Gray, E.D. J. Exp. Med. (1979) [Pubmed]
  31. The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro. Young, J.W., Koulova, L., Soergel, S.A., Clark, E.A., Steinman, R.M., Dupont, B. J. Clin. Invest. (1992) [Pubmed]
  32. Fas/Fas ligand interactions promote activation-induced cell death of NK T lymphocytes. Leite-de-Moraes, M.C., Herbelin, A., Gouarin, C., Koezuka, Y., Schneider, E., Dy, M. J. Immunol. (2000) [Pubmed]
  33. CD4 mAbs prevent progression of alloactivated CD4+ T cells into the S phase of the cell cycle without interfering with early activation signals. Fournel, S., Vincent, C., Assossou, O., Gorman, S.D., Robinet, E., Phillips, J.M., Flacher, M., Cordier, G., Waldmann, H., Revillard, J.P. Transplantation (1996) [Pubmed]
  34. Lymphokine production induced by streptococcal pyrogenic exotoxin-A is selectively down-regulated by pooled human IgG. Skansén-Saphir, U., Andersson, J., Björk, L., Andersson, U. Eur. J. Immunol. (1994) [Pubmed]
  35. Human recombinant interleukin-1 receptor antagonist inhibits lymphocyte blastogenesis induced by concanavalin A. Restorative effect of hrIL-1. Conti, P., Reale, M., Panara, M.R., Barbacane, R.C., Bongrazio, M., Dempsey, R.A. FEBS Lett. (1991) [Pubmed]
  36. Human T-cell heterogeneity as delineated with a specific human thymus lymphocyte antiserum. In vitro effects on mitogen response mixed leukocyte culture, cell-mediated lymphocytotoxicity, and lymphokine production. Woody, J.N., Ahmed, A., Knudsen, R.C., Strong, D.M., Sell, K.W. J. Clin. Invest. (1975) [Pubmed]
  37. Leukocyte procoagulant activity in man: an in vitro correlate of delayed-type hypersensitivity. Geczy, C.L., Meyer, P.A. J. Immunol. (1982) [Pubmed]
  38. Immunologic responsiveness of patients with cancer: relationship to tumor type, stage and prognosis. Humphrey, L.J., Humphrey, M.A., Singla, O., Volenec, F.J. Ann. Surg. (1981) [Pubmed]
  39. Prolonged survival of human skin allografts following thermal injury. Ninnemann, J.L., Fisher, J.C., Frank, H.A. Transplantation (1978) [Pubmed]
  40. Effect of liposomal methylprednisolone on heart allograft survival and immune function in rats. Mishina, E.V., Binder, J., Kupiec-Weglinski, J.W., Jusko, W.J. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
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